دورية أكاديمية
Pyridyl-Linked Hetero Hydrazones: Transmembrane H + /Cl – Symporters with Efficient Antibacterial Activity
| العنوان: | Pyridyl-Linked Hetero Hydrazones: Transmembrane H + /Cl – Symporters with Efficient Antibacterial Activity |
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| المؤلفون: | Abhishek Mondal, Manisha Siwach, Manzoor Ahmad, Sunish Kumar Radhakrishnan, Pinaki Talukdar |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Pharmacology, Biotechnology, Evolutionary Biology, Developmental Biology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, sup >–, potent antibacterial agents, negative bacterial strains, linked hetero hydrazones, evolving challenges posed, efficient antibacterial activity, cell envelope homeostasis, become increasingly difficult, transmembrane h, therefore imperative, specific class, promising avenue, ongoing pursuit, high efficacy, hcl transport, different gram, develop resistance, cooperative protonation, compounds offer, compounds inhibits |
| الوصف: | The development of potent antibacterial agents has become increasingly difficult as bacteria continue to evolve and develop resistance to antibiotics. It is therefore imperative to find effective antimicrobial agents that can address the evolving challenges posed by infectious diseases and antimicrobial resistance. Using artificial transmembrane ion transporters is an emerging and promising avenue to address this issue. We report pyridyl-linked hetero hydrazones as highly efficient transmembrane HCl symporters. These compounds offer an appropriate HCl binding site through cooperative protonation, followed by recognition of chloride ions. HCl transport by these compounds inhibits the growth of different Gram-negative bacterial strains with high efficacy by affecting the cell envelope homeostasis. This specific class of compounds holds substantial promise in the ongoing pursuit of developing highly efficient antibacterial agents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Pyridyl-Linked_Hetero_Hydrazones_Transmembrane_H_sup_sup_Cl_sup_sup_Symporters_with_Efficient_Antibacterial_Activity/25050614Test |
| DOI: | 10.1021/acsinfecdis.3c00455.s001 |
| الإتاحة: | https://doi.org/10.1021/acsinfecdis.3c00455.s001Test https://figshare.com/articles/journal_contribution/Pyridyl-Linked_Hetero_Hydrazones_Transmembrane_H_sup_sup_Cl_sup_sup_Symporters_with_Efficient_Antibacterial_Activity/25050614Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.8E688DA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsinfecdis.3c00455.s001 |
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