Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer
| العنوان: | Tumor necrosis factor receptor signaling modulates carcinogenesis in a mouse model of breast cancer |
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| المؤلفون: | Kruttika Bhat, Le Zhang, Ling He, Neda A. Moatamed, Sara Duhacheck-Muggy, Angeliki Ioannidis, Nhan T. Nguyen, Frank Pajonk |
| المصدر: | Neoplasia (New York, N.Y.) Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 2, Pp 197-209 (2021) |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Proteomics, 0301 basic medicine, Cancer Research, c-Myc, myelocytoma, Organogenesis, medicine.medical_treatment, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Mammary gland, IL-12, interleukin 12, medicine.disease_cause, Receptors, Tumor Necrosis Factor, Mice, Breast cancer, 0302 clinical medicine, Oct4, octamer-binding transcription factor 4, Receptor, Mammary epithelial stem cells, Tumor necrosis factor alpha receptor, Klf4, Krüppel-like factor 4, Mice, Knockout, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, NF-kappa B, ELISA, enzyme-linked immunosorbent assay, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, TNFR, tumor necrosis factor receptor, 3. Good health, Cell Transformation, Neoplastic, medicine.anatomical_structure, Cytokine, 030220 oncology & carcinogenesis, NF-κB signaling, iNOS, inducible nitric oxide synthase, Cytokines, Female, Tumor necrosis factor alpha, Disease Susceptibility, Signal transduction, Signal Transduction, Original article, IKK, the inhibitor of nuclear factor-κB (IκB) kinase, TNFα, tumor necrosis factor alpha, Breast Neoplasms, lcsh:RC254-282, IL-1α, interleukin 1 alpha, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Receptors, Tumor Necrosis Factor, Type II, Autocrine signalling, Alleles, IFN-γ, interferon gamma, business.industry, medicine.disease, Disease Models, Animal, 030104 developmental biology, PMSF, phenylmethylsulfonyl fluoride, DTT, dithiothreitol, CXCL1, C-X-C Motif chemokine ligand 1, Cancer research, business, Carcinogenesis, Sox2, SRY (sex determining region Y)-box 2, Biomarkers |
| الوصف: | Pro-inflammatory conditions have long been associated with mammary carcinogenesis and breast cancer progression. The underlying mechanisms are incompletely understood but signaling of pro-inflammatory cytokine TNFα through its receptors TNFR1 and TNFR2 is a major mediator of inflammation in both obesity and in the response of tissues to radiation, 2 known risk factors for the development of breast cancer. Here, we demonstrated the loss of one TNFR2 allele led to ductal hyperplasia in the mammary gland with increased numbers of mammary epithelial stem cell and terminal end buds. Furthermore, loss of one TNFR2 allele increased the incidence of breast cancer in MMTV-Wnt1 mice and resulted in tumors with a more aggressive phenotype and metastatic potential. The underlying mechanisms include a preferential activation of canonical NF-κB signaling pathway and autocrine production of TNFα. Analysis of the TCGA dataset indicated inferior overall survival for patients with down-regulated TNFR2 expression. These findings unravel the imbalances in TNFR signaling promote the development and progression of breast cancer, indicating that selective agonists of TNFR2 could potentially modulate the risk for breast cancer in high-risk populations. |
| تدمد: | 1476-5586 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af59416ef11a1902b82c9c1a083c8797Test https://doi.org/10.1016/j.neo.2020.12.007Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....af59416ef11a1902b82c9c1a083c8797 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765586 |
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