المؤلفون: PCAWG Evolution Heterogeneity Work, PCAWG Consortium, Gerstung, Moritz, Jolly, Clemency, Leshchiner, Ignaty, Mustonen, Ville, Cao, Shaolong

المساهمون: Organismal and Evolutionary Biology Research Programme, Helsinki Institute for Information Technology, Institute of Biotechnology, Bioinformatics, Department of Computer Science, Doctoral Programme in Computer Science

مصطلحات موضوعية: MUTATIONAL PROCESSES, BRANCHED EVOLUTION, SOMATIC MUTATION, NATURAL-HISTORY, PROGRESSION, BREAST, LANDSCAPE, SELECTION, WOMEN, SEX, 3122 Cancers

وصف الملف: application/pdf

العلاقة: We thank H. Lee-Six and L. Moore for sharing data on mutation burden in normal tissues. This work was supported by the Francis Crick Institute, which receives its core funding from Cancer Research UK (FC001202), the UK Medical Research Council (FC001202) and the Wellcome Trust (FC001202). This project was enabled through the Crick Scientific Computing STP and through access to the MRC eMedLab Medical Bioinformatics infrastructure, supported by the Medical Research Council (grant number MR/L016311/1). M.T. and J.D. are postdoctoral fellows supported by the European Union's Horizon 2020 research and innovation program (Marie Sklodowska-Curie grant agreement number 747852-SIOMICS and 703594-DECODE). J.D. is a postdoctoral fellow of the FWO. F.M., G.M. and K. Yuan acknowledge the support of the University of Cambridge, Cancer Research UK and Hutchison Whampoa Limited. G.M., K. Yuan and F.M. were funded by CRUK core grants C14303/A17197 and A19274. S. Sengupta and Y.J. are supported by NIH R01 CA132897. S.M. is supported by the Vanier Canada Graduate Scholarship. S.C.S. is supported by the NSERC Discovery Frontiers Project, "The Cancer Genome Collaboratory" and NIH Grant GM108308. H.Z. is supported by grant NIMH086633 and an endowed Bao-Shan Jing Professorship in Diagnostic Imaging. W.W. is supported by the US National Cancer Institute (1R01 CA183793 and P30 CA016672). P.T.S. was supported by U24CA210957 and 1U24CA143799. D.C.W. is funded by the Li Ka Shing foundation. P.V.L. is a Winton Group Leader in recognition of the Winton Charitable Foundation's support towards the establishment of The Francis Crick Institute. We acknowledge the contributions of the many clinical networks across ICGC and TCGA who provided samples and data to the PCAWG Consortium, and the contributions of the Technical Working Group and the Germline Working Group of the PCAWG Consortium for collation, realignment and harmonized variant calling of the cancer genomes used in this study. We thank the patients and their families for their participation in the individual ICGC and TCGA projects.; PCAWG Evolution Heterogeneity Work , PCAWG Consortium , Gerstung , M , Jolly , C , Leshchiner , I , Mustonen , V & Cao , S 2020 , ' The evolutionary history of 2,658 cancers ' , Nature , vol. 578 , no. 7793 , pp. 122-+ . https://doi.org/10.1038/s41586-019-1907-7Test; ORCID: /0000-0002-7270-1792/work/87353125; 49f68fd9-6288-4827-9290-516d33638be8; http://hdl.handle.net/10138/325065Test; 000529097800011

الإتاحة: http://hdl.handle.net/10138/325065Test

المؤلفون: Nanou, Afroditi, Miller, M Craig, Zeune, Leonie L, de Wit, Sanne, Punt, Cornelis J A, Groen, Harry J M, Hayes, Daniel F, de Bono, Johann S, Terstappen, Leon W M M

المصدر: Nanou , A , Miller , M C , Zeune , L L , de Wit , S , Punt , C J A , Groen , H J M , Hayes , D F , de Bono , J S & Terstappen , L W M M 2020 , ' Tumour-derived extracellular vesicles in blood of metastatic cancer patients associate with overall survival ' , British Journal of Cancer , vol. 122 , no. 6 , pp. 801-811 . https://doi.org/10.1038/s41416-019-0726-9Test

مصطلحات موضوعية: RESISTANT PROSTATE-CANCER, BRANCHED EVOLUTION, PROGRESSION-FREE, CELLS, EXOSOMES, PREDICT, HETEROGENEITY, MICROVESICLES, EXPRESSION, BIOMARKERS

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/c8f601c7-a8a4-4ddc-90dd-682afec19ed7Test

الإتاحة: https://doi.org/10.1038/s41416-019-0726-9Test
https://hdl.handle.net/11370/c8f601c7-a8a4-4ddc-90dd-682afec19ed7Test
https://research.rug.nl/en/publications/c8f601c7-a8a4-4ddc-90dd-682afec19ed7Test
https://pure.rug.nl/ws/files/112421306/Tumour_derived_extracellular_vesicles_in_blood_of_metastatic_cancer_patients_associate_with_overall_survival.pdfTest

المؤلفون: Deborah R. Caswell, Charles Swanton

المصدر: BMC Medicine, Vol 15, Iss 1, Pp 1-9 (2017)

مصطلحات موضوعية: Intratumour heterogeneity, Tumour progression, Metastasis, Linear evolution, Branched evolution, Competitive evolution, Medicine

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12916-017-0900-yTest; https://doaj.org/toc/1741-7015Test

الوصول الحر: https://doaj.org/article/8c7c15f753004243ae0a50e8f88252f6Test

المؤلفون: Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Chambers, Tim, López Fernández de Villaverde, José Ignacio, Nicol, David, O'Brien, Tim, Larkin, James, Horswell, Stuart, Stares, Mark, Au, Lewis, Jamal-Hanjani, Mariam, Challacombe, Ben, Chandra, Ashish, Hazell, Steve, Eichler-Jonsson, Claudia, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Archana Sinduri, Fernando, Stamp, Gordon, Nye, Emma, Jabbar, Faiz, Spain, Lavinia, Lall, Sharanpreet, Guarch, Rosa, Falzon, Mary, Proctor, Ian, Pickering, Lisa, Gore, Martin E., Watkins, Thomas B. K., Ward, Sophia, Stewart, Aengus, DiNatale, Renzo, Becerra, Maria F., Reznik, Ed, Hsieh, James J., Richmond, Todd A., Mayhew, George F., Hill, Samantha M., McNally, Catherine D., Jones, Carol, Rosenbaum, Heidi, Stanislaw, Stacey, Burgess, Daniel L., Alexander, Nelson R., Swanton, Charles

مصطلحات موضوعية: cell carcinoma, breast-cancer, pancreatic-cancer, tumor thrombus, cytoreductive nephrectomy, branched evolution, natural-history, prostate-cancer, sequencing data, expression

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/MINECO/SAF2016-79847-R; https://www.sciencedirect.com/science/article/pii/S0092867418303891?via%3DihubTest; Cell 173(3) : 581-594 (2018); http://hdl.handle.net/10810/30324Test

الإتاحة: https://doi.org/10.1016/j.cell.2018.03.057Test
http://hdl.handle.net/10810/30324Test

المؤلفون: Kjällquist, Una, Erlandsson, Rikard, Tobin, Nicholas P., Alkodsi, Amjad, Ullah, Ikram, Stalhammar, Gustav, Karlsson, Eva, Hatschek, Thomas, Hartman, Johan, Linnarsson, Sten, Bergh, Jonas

المساهمون: Research Programs Unit, Genome-Scale Biology (GSB) Research Program, Sampsa Hautaniemi / Principal Investigator, Medicum, University of Helsinki

مصطلحات موضوعية: Breast cancer, Metastasis, Exome sequencing, Somatic mutations, AKAP, A-kinase anchoring proteins, MOLECULAR PORTRAITS, BRANCHED EVOLUTION, SUPPRESSOR NM23-H2, COLORECTAL-CANCER, ESTROGEN-RECEPTOR, TUMOR PROGRESSION, BINDING DOMAIN, COPY NUMBER, EXPRESSION, SSECKS/GRAVIN/AKAP12, 3122 Cancers

وصف الملف: application/pdf

العلاقة: This work was supported by grants from Radiumhemmets Forskningsfonder to U. K, the Swedish Research Council (STARGET) to S. L (study design, analysis, interpretation and writing) and U. K (collection, analysis, interpretation and writing), Breast Cancer Theme Center (BRECT), KI AstraZeneca Research Collaboration to S. L (design, analysis, interpretation and writing) and J. B (design, interpretation and writing) and grants from Karolinska Institutet Foundations, Swedish Cancer Society, Cancer Society in Stockholm, KI Stockholm County Council The King Gustaf V Jubilee Fund, Swedish Breast Cancer Association and Marit and Hans Rausing's Initiative Against Breast Cancer to J.B. (design, interpretation and writing) and Swedish Society for Medical Research (SSMF) to J.H. (design and collection).; Kjällquist , U , Erlandsson , R , Tobin , N P , Alkodsi , A , Ullah , I , Stalhammar , G , Karlsson , E , Hatschek , T , Hartman , J , Linnarsson , S & Bergh , J 2018 , ' Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs) ' , BMC Cancer , vol. 18 , 174 . https://doi.org/10.1186/s12885-018-4021Test; ORCID: /0000-0003-3528-4683/work/43736803; 85041836206; 91f2e695-e949-43c4-a7c0-7d505f94675e; http://hdl.handle.net/10138/234186Test; 000424777300002

الإتاحة: http://hdl.handle.net/10138/234186Test

المؤلفون: Turajlic, Samra, Xu, Hang, Litchfield, Kevin, Rowan, Andrew, Horswell, Stuart, Chambers, Tim, O'Brien, Tim, Lopez, Jose I, Watkins, Thomas BK, Nicol, David, Stares, Mark, Challacombe, Ben, Hazell, Steve, Chandra, Ashish, Mitchell, Thomas J, Au, Lewis, Eichler-Jonsson, Claudia, Jabbar, Faiz, Soultati, Aspasia, Chowdhury, Simon, Rudman, Sarah, Lynch, Joanna, Fernando, Archana, Stamp, Gordon, Nye, Emma, Stewart, Aengus, Xing, Wei, Smith, Jonathan C, Escudero, Mickael, Huffman, Adam, Matthews, Nik, Elgar, Greg, Phillimore, Ben, Costa, Marta, Begum, Sharmin, Ward, Sophia, Salm, Max, Boeing, Stefan, Fisher, Rosalie, Spain, Lavinia, Navas, Carolina, Grönroos, Eva, Hobor, Sebastijan, Sharma, Sarkhara, Aurangzeb, Ismaeel, Lall, Sharanpreet, Polson, Alexander, Varia, Mary, Horsfield, Catherine, Fotiadis, Nicos, Pickering, Lisa, Schwarz, Roland F, Silva, Bruno, Herrero, Javier, Luscombe, Nick M, Jamal-Hanjani, Mariam, Rosenthal, Rachel, Birkbak, Nicolai J, Wilson, Gareth A, Pipek, Orsolya, Ribli, Dezso, Krzystanek, Marcin, Csabai, Istvan, Szallasi, Zoltan, Gore, Martin, McGranahan, Nicholas, Van Loo, Peter, Campbell, Peter, Larkin, James, Swanton, Charles, TRACERx Renal Consortium

مصطلحات موضوعية: branched evolution, cancer evolution, chromosome instability, deterministic evolution, intratumor heterogeneity, linear evolution, metastasis, punctuated evolution, renal cell cancer, tumor diversity, Adult, Aged, 80 and over, Alleles, Biomarkers, Tumor, Carcinoma, Renal Cell, Chromosomes, Clonal Evolution, Disease Progression, Evolution, Molecular, Female, Genetic Heterogeneity, Genetic Variation, Humans, Kidney Neoplasms, Longitudinal Studies, Male

وصف الملف: Print-Electronic; application/pdf

العلاقة: https://www.repository.cam.ac.uk/handle/1810/278192Test

الإتاحة: https://doi.org/10.17863/CAM.25535Test
https://www.repository.cam.ac.uk/handle/1810/278192Test

المؤلفون: Turajlic, S, Xu, H, Litchfield, K, Rowan, A, Chambers, T, Lopez, JI, Nicol, D, O'Brien, T, Larkin, J, Horswell, S, Stares, M, Au, L, Jamal-Hanjani, M, Challacombe, B, Chandra, A, Hazell, S, Eichler-Jonsson, C, Soultati, A, Chowdhury, S, Rudman, S, Lynch, J, Fernando, A, Stamp, G, Nye, E, Jabbar, F, Spain, L, Lall, S, Guarch, R, Falzon, M, Proctor, I, Pickering, L, Gore, M, Watkins, TBK, Ward, S, Stewart, A, DiNatale, R, Becerra, MF, Reznik, E, Hsieh, JJ, Richmond, TA, Mayhew, GF, Hill, SM, McNally, CD, Jones, C, Rosenbaum, H, Stanislaw, S, Burgess, DL, Alexander, NR, Swanton, C

المصدر: Cell , 173 (3) 581-594.e12. (2018)

مصطلحات موضوعية: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, CELL CARCINOMA, BREAST-CANCER, PANCREATIC-CANCER, TUMOR THROMBUS, CYTOREDUCTIVE NEPHRECTOMY, BRANCHED EVOLUTION, NATURAL-HISTORY, PROSTATE-CANCER, SEQUENCING DATA, EXPRESSION

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10050913/1/Turajlic_TrackingCancer.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10050913Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10050913/1/Turajlic_TrackingCancer.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10050913Test/

المؤلفون: Turajlic, S, Xu, H, Litchfield, K, Rowan, A, Horswell, S, Chambers, T, O'Brien, T, Lopez, JI, Watkins, TBK, Nicol, D, Stares, M, Challacombe, B, Hazell, S, Chandra, A, Mitchell, TJ, Au, L, Eichler-Jonsson, C, Jabbar, F, Soultati, A, Chowdhury, S, Rudman, S, Lynch, J, Fernando, A, Stamp, G, Nye, E, Stewart, A, Xing, W, Smith, JC, Escudero, M, Huffman, A, Matthews, N, Elgar, G, Phillimore, B, Costa, M, Begum, S, Ward, S, Salm, M, Boeing, S, Fisher, R, Spain, L, Navas, C, Grönroos, E, Hobor, S, Sharma, S, Aurangzeb, I, Lall, S, Polson, A, Varia, M, Horsfield, C, Fotiadis, N, Pickering, L, Schwarz, RF, Silva, B, Herrero, J, Luscombe, NM, Jamal-Hanjani, M, Rosenthal, R, Birkbak, NJ, Wilson, GA, Pipek, O, Ribli, D, Krzystanek, M, Csabai, I, Szallasi, Z, Gore, M, McGranahan, N, Van Loo, P, Campbell, P, Larkin, J, Swanton, C, TRACERx Renal Consortium, .

المصدر: Cell , 173 (3) 595-610.e11. (2018)

مصطلحات موضوعية: Branched evolution, cancer evolution, chromosome instability, deterministic evolution, intratumor heterogeneity, linear evolution, metastasis, punctuated evolution, renal cell cancer, tumor diversity

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10047153/1/Turajlic_1-s2.0-S0092867418303751-main.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10047153Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10047153/1/Turajlic_1-s2.0-S0092867418303751-main.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10047153Test/

المؤلفون: Caswell, DR, Swanton, C

المصدر: BMC Medicine , 15 , Article 133. (2017)

مصطلحات موضوعية: Intratumour heterogeneity, Tumour progression, Metastasis, Linear evolution, Branched evolution, Competitive evolution, Cooperative evolution, Mutation burden, Immunotherapy, Aneuploidy tolerance

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10050887/1/Caswell_Role%20of%20Tumour.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10050887Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10050887/1/Caswell_Role%20of%20Tumour.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10050887Test/

المؤلفون: Deborah R Caswell (11284452), Charles Swanton (236153)

مصطلحات موضوعية: Ecology,Evolution & Ethology, Computational & Systems Biology, Tumour Biology, Signalling & Oncogenes, Genetics & Genomics, Genome Integrity & Repair, Human Biology & Physiology, Chemical Biology & High Throughput, Aneuploidy tolerance, Branched evolution, Competitive evolution, Cooperative evolution, Immunotherapy, Intratumour heterogeneity, Linear evolution, Metastasis, Mutation burden, Tumour progression, Genetic Heterogeneity, Humans, Immune Evasion, Neoplasm Metastasis, Neoplasms, Treatment Outcome, Swanton FC001169, 11 Medical and Health Sciences, General & Internal Medicine

العلاقة: https://figshare.com/articles/journal_contribution/The_role_of_tumour_heterogeneity_and_clonal_cooperativity_in_metastasis_immune_evasion_and_clinical_outcome/15180057Test

الإتاحة: https://doi.org/10.25418/crick.15180057.v1Test