التفاصيل البيبلوغرافية
| العنوان: |
Three-Dimensional-Printed Spherical Hollow Structural Scaffolds for Guiding Critical-Sized Bone Regeneration |
| المؤلفون: |
Xiao Liu, Jianpeng Gao, Jianheng Liu, Junyao Cheng, Zhenchuan Han, Zijian Li, Zhengyang Chang, Licheng Zhang, Ming Li, Peifu Tang |
| سنة النشر: |
2024 |
| المجموعة: |
Smithsonian Institution: Figshare |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Genetics, Biotechnology, Ecology, Sociology, Cancer, Plant Biology, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, vivo biological experiments, vitro cytological assays, term bone reconstruction, sized bone regeneration, sized bone defects, rabbit femoral condyle, novel therapeutic approach, innovative strategy presents, important therapeutic approach, could effectively repair, complex medical issue, certain challenges associated, bone tissue engineering, bone growth within, sized bone defect, bone defect repair, guiding bone regeneration |
| الوصف: |
The treatment of bone tissue defects continues to be a complex medical issue. Recently, three-dimensional (3D)-printed scaffold technology for bone tissue engineering (BTE) has emerged as an important therapeutic approach for bone defect repair. Despite the potential of BTE scaffolds to contribute to long-term bone reconstruction, there are certain challenges associated with it including the impediment of bone growth within the scaffolds and vascular infiltration. These difficulties can be resolved by using scaffold structural modification strategies that can effectively guide bone regeneration. This study involved the preparation of biphasic calcium phosphate spherical hollow structural scaffolds (SHSS) with varying pore sizes using 3D printing (photopolymerized via digital light processing). The chemical compositions, microscopic morphologies, mechanical properties, biocompatibilities, osteogenic properties, and impact on repairing critical-sized bone defects of SHSS were assessed through characterization analyses, in vitro cytological assays, and in vivo biological experiments. The results revealed the biomimetic properties of SHSS and their favorable biocompatibility. The scaffolds stimulated cell adhesion, proliferation, differentiation, and migration and facilitated the expression of osteogenic genes and proteins, including Col-1, OCN, and OPN. Furthermore, they could effectively repair a critical-sized bone defect in a rabbit femoral condyle by establishing an osteogenic platform and guiding bone regeneration in the defect region. This innovative strategy presents a novel therapeutic approach for assessing critical-sized bone defects. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Three-Dimensional-Printed_Spherical_Hollow_Structural_Scaffolds_for_Guiding_Critical-Sized_Bone_Regeneration/25418558Test |
| DOI: |
10.1021/acsbiomaterials.3c01956.s001 |
| الإتاحة: |
https://doi.org/10.1021/acsbiomaterials.3c01956.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.4C6F43AA |
| قاعدة البيانات: |
BASE |
