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1دورية أكاديمية
المؤلفون: Zak, Krzysztof M., Grudnik, Przemyslaw, Guzik, Katarzyna, Zieba, Bartosz J., Musielak, Bogdan, Dömling, Alexander, Dubin, Grzegorz, Holak, Tad A.
المصدر: Zak , K M , Grudnik , P , Guzik , K , Zieba , B J , Musielak , B , Dömling , A , Dubin , G & Holak , T A 2016 , ' Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1) ' , Oncotarget , vol. 7 , no. 21 , pp. 30323-30335 . https://doi.org/10.18632/oncotarget.8730Test
مصطلحات موضوعية: Checkpoint inhibitor, Immunotherapy, Small molecule, X-ray structure, bms 202, bms 242, bms 37, bms 8, programmed death 1 ligand 1, programmed death 1 receptor, protein inhibitor, unclassified drug, article, binding affinity, complex formation, conformational transition, controlled study, crystal structure, drug potency, drug protein binding, drug research, drug structure, drug synthesis, drug targeting, human, inhibition kinetics, molecular dynamics, nuclear magnetic resonance spectroscopy, protein protein interaction, protein stability
وصف الملف: application/pdf
الإتاحة: https://doi.org/10.18632/oncotarget.8730Test
https://hdl.handle.net/11370/66b38ebe-19cb-4ca3-bd38-d873a99853beTest
https://research.rug.nl/en/publications/66b38ebe-19cb-4ca3-bd38-d873a99853beTest
https://pure.rug.nl/ws/files/58345734/8730_132617_4_PB.pdfTest -
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المؤلفون: Katarzyna Guzik, Przemyslaw Grudnik, Bartosz J. Zieba, Krzysztof M. Zak, Grzegorz Dubin, Bogdan Musielak, Alexander Dömling, Tad A. Holak
المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)
المصدر: Oncotarget
Oncotarget, 7(21), 30323-30335. Impact Journals LLCمصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Magnetic Resonance Spectroscopy, CLINICAL ACTIVITY, Programmed Cell Death 1 Receptor, drug protein binding, Plasma protein binding, ANTI-PD-L1 ANTIBODY, Pharmacology, Crystallography, X-Ray, drug research, THERAPY, B7-H1 Antigen, PROTEIN-PROTEIN INTERACTIONS, 0302 clinical medicine, Checkpoint inhibitor, binding affinity, conformational transition, Molecular Structure, Drug discovery, Chemistry, CHECKPOINT BLOCKADE, article, Ligand (biochemistry), Small molecule, unclassified drug, bms 8, Oncology, protein stability, MPDL3280A, 030220 oncology & carcinogenesis, protein protein interaction, CANCER-IMMUNOTHERAPY, immunotherapy, Immunotherapy, drug potency, Protein Binding, Signal Transduction, Research Paper, crystal structure, bms 37, medicine.drug_class, small molecule, Monoclonal antibody, Protein–protein interaction, Small Molecule Libraries, 03 medical and health sciences, Protein Domains, complex formation, inhibition kinetics, medicine, Humans, controlled study, human, nuclear magnetic resonance spectroscopy, STABILITY, drug targeting, bms 202, programmed death 1 receptor, molecular dynamics, NMR, programmed death 1 ligand 1, drug structure, checkpoint inhibitor, 030104 developmental biology, Targeted drug delivery, protein inhibitor, Biophysics, bms 242, drug synthesis, X-ray structure, INHIBITORS
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4077c489c1a3e54f918f43d3ca7d076cTest
https://hdl.handle.net/11370/66b38ebe-19cb-4ca3-bd38-d873a99853beTest