دورية أكاديمية
Diagnostic Value of Ascitic Tumor Markers for Gastric Cancer-associated Malignant Ascites
| العنوان: | Diagnostic Value of Ascitic Tumor Markers for Gastric Cancer-associated Malignant Ascites |
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| المؤلفون: | Yaewon Yang, Hong Jun Kim, Se-il Go, Woo Kyun Bae, Eun-Kee Song, Seonggyu Byeon, Hee Kyung Kim, Yusook Jeong, Jihyun Kwon, Ki Hyeong Lee, Hee Bok Chae, Seung-Myoung Son, Dae Hoon Kim, Hyo Yung Yun, Hye Sook Han |
| المصدر: | The Korean Journal of Helicobacter and Upper Gastrointestinal Research, Vol 22, Iss 1, Pp 38-49 (2022) |
| بيانات النشر: | Yong Chan Lee, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Internal medicine |
| مصطلحات موضوعية: | ascites, biomakers, tumor, diagnosis, stomach neoplasms, Internal medicine, RC31-1245 |
| الوصف: | Background/Aims Peritoneal carcinomatosis with malignant ascites is common in patients with advanced gastric cancer (GC). The detection of tumor cells is the gold standard for the diagnosis of malignant ascites; however, it often requires complementary tests because of its low sensitivity. Herein, we measured the levels of tumor markers in the malignant ascites of GC patients (GC-ascites) and benign ascites of liver cirrhosis patients (LC-ascites) to elucidate the diagnostic value of tumor markers in GC-ascites. Materials and Methods The levels of CEA, cancer antigen 72-4 (CA 72-4), CA 19-9, and CA 125 were measured in 138 GC-ascites and 64 LC-ascites samples obtained from the National Biobank of Korea. We performed receiver operating characteristic curve analysis to determine the optimal cutoff value for each tumor marker. Results CEA, CA 72-4, and CA 19-9 levels were significantly higher in GC-ascites than in LC-ascites. There was no difference in tumor marker levels between GC-ascites samples irrespective of cytology. CEA, CA 72-4, and CA 19-9 had sensitivities of 85.5%, 79.0%, and 61.6%, respectively, and specificities of 96.8%, 100.0%, and 89.1%, respectively, for distinguishing GC-ascites samples from LC-ascites samples. The diagnostic accuracy was improved by combining two or more tumor markers. The combination of CEA and CA 72-4 showed the highest sensitivity (86.2%) and specificity (100%). Conclusions Measurement of tumor markers, such as CEA, CA 72-4, and CA 19-9, in ascites samples could help diagnose GC-ascites, and combining two or more tumor markers could further increase the diagnostic yield, even in cytology-negative patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 1738-3331 |
| العلاقة: | http://helicojournal.org/upload/pdf/kjhugr-2021-0058.pdfTest; https://doaj.org/toc/1738-3331Test |
| DOI: | 10.7704/kjhugr.2021.0058 |
| الوصول الحر: | https://doaj.org/article/46b4f70e956e4ac488355d437999a76cTest |
| رقم الانضمام: | edsdoj.46b4f70e956e4ac488355d437999a76c |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 17383331 |
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| DOI: | 10.7704/kjhugr.2021.0058 |