المؤلفون: Kranti A. Mapuskar, Casey F. Pulliam, Ann Tomanek-Chalkley, Prerna Rastogi, Hsiang Wen, Sanjana Dayal, Benjamin R. Griffin, Diana Zepeda-Orozco, Amy L. Sindler, Carryn M. Anderson, Robert Beardsley, Eugene P. Kennedy, Douglas R. Spitz, Bryan G. Allen

المصدر: Redox Biology, Vol 70, Iss , Pp 103022- (2024)

مصطلحات موضوعية: Acute kidney injury (AKI), Chronic kidney disease (CKD), Cisplatin, Superoxide dismutase mimetic, Avasopasem manganese, Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2213231723004238Test; https://doaj.org/toc/2213-2317Test

الوصول الحر: https://doaj.org/article/700536df35bc4b5690c5fab7c5eab07cTest

المؤلفون: Amira Zaher, Kranti A. Mapuskar, Michael S. Petronek, Munir R. Tanas, Alexandra L. Isaacson, Rebecca D. Dodd, Mohammed Milhem, Muhammad Furqan, Douglas R. Spitz, Benjamin J. Miller, Robert A. Beardsley, Bryan G. Allen

المصدر: Antioxidants, Vol 13, Iss 5, p 587 (2024)

مصطلحات موضوعية: soft tissue sarcoma, radiation therapy, wound healing, superoxide dismutase mimetic, avasopasem manganese, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2076-3921/13/5/587Test; https://doaj.org/toc/2076-3921Test

الوصول الحر: https://doaj.org/article/b0197ae339824cb0bd61d1901b655ed0Test

المؤلفون: K.A. Mapuskar, G. Vasquez Martinez, C.F. Pulliam, M.S. Petronek, E.J. Steinbach, V. Monga, M. Furqan, J.G. Jetton, D.P. Saunders, A. Pearce, S. Davidson, L. Pitre, N.E. Dunlap, R. Fairbanks, C.M. Lee, S.L. Mott, K.L. Bodeker, Huang Cl, J.M. Buatti, C.M. Anderson, R.A. Beardsley, J.T. Holmlund, D. Zepeda-Orozco, D.R. Spitz, B.G. Allen

المصدر: Redox Biology, Vol 60, Iss , Pp 102599- (2023)

مصطلحات موضوعية: Superoxide dismutase mimetic, Avasopasem manganese, GC4419, Cisplatin, Radiation, Kidney injury, Medicine (General), R5-920, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2213231722003718Test; https://doaj.org/toc/2213-2317Test

الوصول الحر: https://doaj.org/article/46fd3b735b014bfca6201fa21b97d429Test

المؤلفون: Sonis ST

المصدر: Drug Design, Development and Therapy, Vol Volume 15, Pp 1021-1029 (2021)

مصطلحات موضوعية: superoxide dismutase, mucositis, radiation, avasopasem manganese, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/superoxide-dismutase-as-an-intervention-for-radiation-therapy-associat-peer-reviewed-article-DDDTTest; https://doaj.org/toc/1177-8881Test

الوصول الحر: https://doaj.org/article/a1e9a2afc3a443a2a1ab4b32520ec08dTest

المصدر: A Phase 1, Open-Label, Single-Dose, Parallel-Group Study to Evaluate the Effects of Renal Impairment on the Pharmacokinetics, Safety and Tolerability of GC4419

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT05412472Test

المصدر: A Pilot, Randomized, Placebo-Controlled Trial of GC4419 (Avasopasem Manganese) in Patients With Critical Illness Due to SARS-CoV-2 Infection (COVID-19)

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04555096Test

المصدر: An Open Label Multi-Center Study of the Effects of GC4419 When Administered to Reduce the Incidence and Severity of Severe Oral Mucositis Associated With Chemo RT for Locally Advanced, Non-Metastatic Head and Neck Cancer

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04529850Test

المصدر: A Phase 2a Open-Label Trial of the Effects of Intravenous GC4419 on the Incidence and Severity of Esophagitis in Subjects Receiving Chemoradiotherapy for Lung Cancer

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT04225026Test

المصدر: Phase 1, Open-label, One-arm, Fixed-sequence Study to Evaluate the Effects of 90 mg Intravenous Infusions of GC4419 on the Single Dose Pharmacokinetics of Dextromethorphan in Healthy Adult Subjects

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03792971Test

المصدر: Anderson CM, Lee CM, Kelley JR, et al. ROMAN: Phase 3 trl of avasopasem manganese (GC4419) for severe oral mucos (SOM) patnts receg chemoradtherapy (CRT) for locally advanced, nonmetastat head and neck cancer (LAHNC). Journal of Clal Oncology 2022 40:16_suppl, 6005-6005
Saunders D, Lee C, Kelley J, et al. ROMAN: Phase 3 trl of avasopasem to reduce chemoradtherapy (CRT)-related severe oral mucos (SOM) patnts wh head and neck cancer (HNC). Support Care Cancer 30 (Suppl 1), 1-207 (2022).
ROMAN: Reduction in Oral Mucositis With Avasopasem Manganese (GC4419) - Phase 3 Trial in Patients Receiving Chemoradiotherapy for Locally-Advanced, Non-Metastatic Head and Neck Cancer

الوصول الحر: https://clinicaltrials.gov/ct2/show/NCT03689712Test