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المؤلفون: Binxiang Cai, Chunyan Liao, Danxue He, Jingmeng Chen, Jiahuai Han, Jiaying Lu, Kaiqi Qin, Wenxu Liang, Xiaoling Wu, Zuguo Liu, Yalin Wu
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: p-MLKL, phosphorylated mixed lineage kinase domain-like protein, genetic structures, RIP3, receptor interacting protein kinase 3, ONL, outer nuclear layer, IS, inner segment, Biochemistry, Mice, Stargardt Disease, GSDME, gasdermin E, PCD, programmed cell death, AMD, age-related macular degeneration, qRT–PCR, quantitative real-time PCR, c-Jun N-terminal kinase, reactive oxygen species, LDH, lactate dehydrogenase, Caspase 3, pyroptosis, gasdermin E, apoptosis, RDH8, all-trans-retinol dehydrogenase 8, JNK, c-Jun N-terminal kinase, Retinaldehyde, Stargardt's disease, HMGB1, high-mobility group box 1, Research Article, PARP, poly-ADP-ribose polymerase, Pore Forming Cytotoxic Proteins, RPE, retinal pigment epithelium, GSDME-N, N-terminal fragment of GSDME, IgG, immunoglobulin G, STGD1, Stargardt's disease 1, Retina, atROL, all-trans-retinol, cDNA, complementary DNA, ROS, reactive oxygen species, Animals, Photoreceptor Cells, TEM, transmission electron microscopy, age-related macular degeneration, Molecular Biology, Nec-1, necrostatin-1, NAC, N-acetyl-l-cysteine, Cell Biology, photoreceptor, eye diseases, ABCA4, ABC (subfamily A, member 4) transporter, atRAL, all-trans-retinal, Cyt c, cytochrome c, ATP-Binding Cassette Transporters, sense organs, OS, outer segment
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b29afe488a258683562e75a6793061Test
https://doi.org/10.1016/j.jbc.2021.101553Test -
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المؤلفون: Philip D. Kiser, Krzysztof Palczewski
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 11-cis retinal, RPE65, Biochemistry, CCD, carotenoid cleavage dioxygenase, Macular Degeneration, AAV, adeno-associated virus, 11cRDH, 11-cis-RDH (RDH5), AWAT2 (MFAT), acyl-CoA wax alcohol acyltransferase 2, RCD, rod–cone dystrophy, atRDH, all-trans-RDH, RNAseq, next-generation RNA sequencing, IRBP, interphotoreceptor retinoid-binding protein, 11cRE, 11-cis-retinyl esters, CRISPR/Cas9, clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, LCA, Leber congenital amaurosis, RGR, ABCA4, ATP-binding cassette subfamily A member 4, adRP, autosomal dominant retinitis pigmentosa, 11cRAL, 11-cis-retinal, NHEJ, nonhomologous end joining, GLF, gain and loss of function, CSNB, congenital stationary blindness, ND, nitrosotalea devanaterra, Retinal Pigments, Visual phototransduction, Biochemistry & Molecular Biology, G protein-coupled receptor (GPCR), Reviews, PAM sequence, protospacer adjacent motif, GoF, gain of function, 03 medical and health sciences, Isomerism, Ocular, Retinitis pigmentosa, Genetics, Humans, Retinal G protein coupled receptor, All trans retinol, G protein-coupled receptor, LoF, loss of function, Molecular Biology, Eye Disease and Disorders of Vision, LRAT, lecithin:retinol acyltransferase, medicine.disease, DSBs, DNA double-stranded breaks, eye diseases, FDA, U.S. Food and Drug Administration, 030104 developmental biology, chemistry, rhodopsin, Neuroscience, 0301 basic medicine, retina, genetic structures, Vision, CRALBP, retinaldehyde-binding protein, arRP, autosomal recessive RP, Neurodegenerative, retinoid cycle, Medical and Health Sciences, chemistry.chemical_compound, NIH, National Institutes of Health, 11cROL, 11-cis-retinol, BCO, β-carotene 15,15′-dioxygenase, AMD, age-related macular degeneration, HDR, homology-directed repair, Rho, rhodopsin, RGR, retinal G-protein-coupled receptor, Biological Sciences, NinaB, neither inactivation nor afterpotential mutant B carotenoid oxygenases, NRL, retina-specific leucine zipper protein, eye, OS, the photoreceptor outer segments, medicine.anatomical_structure, HRAS, HRas proto-oncogene (GTPase), Vertebrates, Retinal Cone Photoreceptor Cells, cis-trans-Isomerases, RPE, retinal pigment epithelium, Biology, visual cycle, ER, endoplasmic reticulum, atROL, all-trans-retinol, Rare Diseases, PDB, Protein Data Bank, medicine, Animals, RDH, retinol dehydrogenase, RP, retinitis pigmentosa, Vision, Ocular, RPE65, retinoid isomerase, Retinal pigment epithelium, 030102 biochemistry & molecular biology, Neurosciences, Retinal, Cell Biology, CMV, cytomegalovirus, atRE, all-trans-retinyl esters, Chemical Sciences, atRAL, all-trans-retinal, sense organs, Luxturna, voretigene neparvovec-rzyl
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dd9fba85a79ff8ef5fa8fa72c62621Test
https://pubmed.ncbi.nlm.nih.gov/33187985Test -
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المؤلفون: Yan Wang, Yalin Wu, Zuguo Liu, Jingmeng Chen, Chao Chen
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, Retinal degeneration, STEAP3, six-transmembrane epithelial antigen of prostate 3, genetic structures, STGD1, autosomal recessive Stargardt disease, TFRC, transferrin receptor, ONL, outer nuclear layer, Mitochondrion, medicine.disease_cause, Biochemistry, Photoreceptor cell, Mice, DMT1, Divalent metal transporter 1, GSH, glutathione, Stargardt Disease, oxidative stress, iron metabolism, AMD, age-related macular degeneration, IREB2, Iron-responsive element binding protein 2, POS, photoreceptor outer segments, chemistry.chemical_classification, Deferoxamine mesylate, LDH, lactate dehydrogenase, Chemistry, TEM, transmission electron microscope, lipid peroxidation, LED, light emitting diode, Cell biology, medicine.anatomical_structure, cell death, Retinaldehyde, Photoreceptor Cells, Vertebrate, Research Article, Programmed cell death, macular degeneration, 03 medical and health sciences, ROS, reactive oxygen species, medicine, Animals, Ferroptosis, Molecular Biology, Reactive oxygen species, Retina, 030102 biochemistry & molecular biology, Cell Biology, medicine.disease, all-trans-retinal, photoreceptor, eye diseases, TF, transferrin, Mice, Inbred C57BL, 030104 developmental biology, CP, ceruloplasmin, atRAL, all-trans-retinal, H&E, hematoxylin and eosin, sense organs, FPN, Ferroportin, Reactive Oxygen Species, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e528672cccb4554ebf9c4e807e79212aTest
https://pubmed.ncbi.nlm.nih.gov/33334878Test