التفاصيل البيبلوغرافية
| العنوان: |
A Radical Addition Approach to a Heptafluoroisopropyl Substituted Arene, Combined with a Highly Diastereoselective Annulation Reaction To Synthesize the Tricyclic Core of BMS-986251 |
| المؤلفون: |
William P. Gallagher (1508725), John R. Coombs (1334916), Carlos A. Guerrero (1264551), Eric M. Simmons (2245837), Francisco González-Bobes (1508401) |
| سنة النشر: |
1753 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Microbiology, Genetics, Molecular Biology, Physiology, Biotechnology, Evolutionary Biology, Ecology, Immunology, Developmental Biology, Cancer, Computational Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Information Systems not elsewhere classified, perfluoro isopropyl moiety, novel diastereoselective annulation, 3 isolations using, radical addition approach, 10 , radical mechanism, tricyclic core, step installation, single stereoisomer, pyrrolidine ring, new route, asymmetric route, 6 steps |
| الوصف: |
We have devised an asymmetric route to the tricyclic core 10 of BMS-986251. The six-step synthesis utilizes readily available starting materials, involves the one-step installation of the perfluoro isopropyl moiety through a radical mechanism, and leverages a novel diastereoselective annulation to build the pyrrolidine ring. Overall, 10 was obtained in 49% yield as a single stereoisomer in 6 steps and 3 isolations using this new route. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/A_Radical_Addition_Approach_to_a_Heptafluoro_isopropyl_Substituted_Arene_Combined_with_a_Highly_Diastereoselective_Annulation_Reaction_To_Synthesize_the_Tricyclic_Core_of_BMS-986251/16980645Test |
| DOI: |
10.1021/acs.oprd.1c00338.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.oprd.1c00338.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.C834E04C |
| قاعدة البيانات: |
BASE |
