The Role of Astrocytes in the Neurorepair Process
| العنوان: | The Role of Astrocytes in the Neurorepair Process |
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| المؤلفون: | Lennia Soares Mota, Friederike Klempin, Raphaela Almeida Chiareli, Bruno Lemes Marques, Gustavo Carvalho, Mauro Cunha Xavier Pinto, Renato Santiago Gomez, Onésia Cristina Oliveira-Lima, Rodrigo Mello Gomes, Marcel Leist, Alexander Birbrair, Fabrício Simão |
| المصدر: | Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, Vol 9 (2021) |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell signaling, QH301-705.5, Central nervous system, Synaptogenesis, astrocytes, brain damage, neurorepair, synaptogenesis, neurogenesis, Review, Brain damage, Biology, Cell and Developmental Biology, ddc:570, medicine, Biology (General), neurorepair, Neuroinflammation, synaptogenesis, Neurogenesis, astrocytes, brain damage, Cell Biology, medicine.disease, Astrogliosis, neurogenesis, medicine.anatomical_structure, Signal transduction, medicine.symptom, Neuroscience, Developmental Biology |
| الوصف: | Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and metabolism, the modulation of synaptic activity by capturing and recycle of neurotransmitters and maintenance of the blood-brain barrier. During injuries and infections, astrocytes act in cerebral defense through heterogeneous and progressive changes in their gene expression, morphology, proliferative capacity, and function, which is known as reactive astrocytes. Thus, reactive astrocytes release several signaling molecules that modulates and contributes to the defense against injuries and infection in the central nervous system. Therefore, deciphering the complex signaling pathways of reactive astrocytes after brain damage can contribute to the neuroinflammation control and reveal new molecular targets to stimulate neurorepair process. In this review, we present the current knowledge about the role of astrocytes in brain damage and repair, highlighting the cellular and molecular bases involved in synaptogenesis and neurogenesis. In addition, we present new approaches to modulate the astrocytic activity and potentiates the neurorepair process after brain damage. |
| وصف الملف: | application/pdf |
| تدمد: | 2296-634X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60d6e0a70f9a1053fe4722a0ce810fdTest https://doi.org/10.3389/fcell.2021.665795Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c60d6e0a70f9a1053fe4722a0ce810fd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2296634X |
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