المؤلفون: Michael T. Heneka, Laura Haas, Jochen Herms, Franziska Seeser, Markus P. Kummer, Chris G. Parsons, Gerhard Rammes, Kaichuan Zhu, Korinna Mattusch

المصدر: Neuropharmacology 140, 184-192 (2018). doi:10.1016/j.neuropharm.2018.07.021

مصطلحات موضوعية: drug effects [Excitatory Postsynaptic Potentials], 0301 basic medicine, Amyloid beta, AbetapE3 peptide, Dendritic Spines, antagonists & inhibitors [Amyloid beta-Peptides], antagonists & inhibitors [Peptide Fragments], Long-Term Potentiation, physiology [Hippocampus], pharmacology [Piperidines], AMPA receptor, Pharmacology, Hippocampus, 03 medical and health sciences, Cellular and Molecular Neuroscience, Mice, 0302 clinical medicine, Piperidines, Acetamides, Animals, ddc:610, Receptor, drug effects [Dendritic Spines], pharmacology [Acetamides], Amyloid beta-Peptides, biology, Dose-Response Relationship, Drug, Chemistry, Antagonist, Excitatory Postsynaptic Potentials, toxicity [Peptide Fragments], Long-term potentiation, amyloid beta-protein (1-40), adverse effects [Peptide Fragments], amyloid beta-protein (1-42), radiprodil, Peptide Fragments, toxicity [Amyloid beta-Peptides], 030104 developmental biology, Toxicity, biology.protein, drug effects [Long-Term Potentiation], NMDA receptor, Tetanic stimulation, 3NTyr10-Ab peptide, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ede97aa055511209c420904183444fTest
https://pubmed.ncbi.nlm.nih.gov/30016667Test

المؤلفون: Hugo Balleza-Tapia, André Fisahn, Gefei Chen, Sophie Crux, Yuniesky Andrade-Talavera, Daniela Papadia, Jan Johansson, Pablo Dolz-Gaitón

المصدر: eLife 7, e37703 (2018). doi:10.7554/eLife.37703
eLife, Vol 7 (2018)
eLife

مصطلحات موضوعية: 0301 basic medicine, Male, deficiency [TRPV Cation Channels], Mouse, hippocampus, antagonists & inhibitors [Amyloid beta-Peptides], antagonists & inhibitors [Peptide Fragments], drug effects [Pyramidal Cells], Action Potentials, Hippocampus, Gene Expression, genetics [Alzheimer Disease], Hippocampal formation, Tissue Culture Techniques, chemistry.chemical_compound, pathology [Alzheimer Disease], Mice, Cognition, 0302 clinical medicine, physiology [Action Potentials], Gamma Rhythm, drug therapy [Alzheimer Disease], Cognitive decline, Biology (General), Mice, Knockout, cytology [Pyramidal Cells], biology, genetics [TRPV Cation Channels], Chemistry, physiology [Gamma Rhythm], Pyramidal Cells, General Neuroscience, musculoskeletal, neural, and ocular physiology, physiology [Cognition], General Medicine, amyloid beta-protein (1-42), CA3 Region, Hippocampal, drug effects [CA3 Region, Hippocampal], amyloid-beta, Recombinant Proteins, Electrodes, Implanted, cytology [CA3 Region, Hippocampal], metabolism [CA3 Region, Hippocampal], metabolism [Pyramidal Cells], drug effects [Cognition], pharmacology [Peptide Fragments], Medicine, pharmacology [Recombinant Proteins], lipids (amino acids, peptides, and proteins), Alzheimer's disease, gamma oscillations, Capsazepine, metabolism [Alzheimer Disease], Research Article, Agonist, medicine.drug_class, Amyloid beta, QH301-705.5, Science, TRPV1, TRPV Cation Channels, drug effects [Gamma Rhythm], Models, Biological, General Biochemistry, Genetics and Molecular Biology, capsazepine, 03 medical and health sciences, Alzheimer Disease, medicine, Animals, Humans, Amyloid beta-Peptides, General Immunology and Microbiology, antagonists & inhibitors [Capsaicin], drug effects [Action Potentials], Microtomy, TRPV1 protein, mouse, medicine.disease, Peptide Fragments, Mice, Inbred C57BL, TrpV1 receptor, 030104 developmental biology, nervous system, pharmacology [Amyloid beta-Peptides], pharmacology [Capsaicin], biology.protein, analogs & derivatives [Capsaicin], neuronal network, Capsaicin, Neuroscience, ddc:600, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce47602eb69dfb0497d2ddf57594056Test
https://pub.dzne.de/record/140364Test

المؤلفون: Nenad Bogdanovic, Magdalena Sastre, Callum Parr, Loukia Katsouri, Michael Willem

المصدر: Journal of Alzheimer's disease 25(1), 151-162 (2011). doi:10.3233/JAD-2011-101356

مصطلحات موضوعية: Male, antagonists & inhibitors [Amyloid beta-Peptides], PPARGC1A protein, human, Down-Regulation, Peroxisome proliferator-activated receptor, physiology [PPAR gamma], pathology [Alzheimer Disease], antagonists & inhibitors [Transcription Factors], Mice, Downregulation and upregulation, Alzheimer Disease, Transcription (biology), Cell Line, Tumor, biosynthesis [Amyloid beta-Peptides], antagonists & inhibitors [Heat-Shock Proteins], Animals, Humans, ddc:610, Transcription factor, Heat-Shock Proteins, Aged, Aged, 80 and over, chemistry.chemical_classification, Amyloid beta-Peptides, General Neuroscience, General Medicine, Transfection, physiology [Heat-Shock Proteins], Middle Aged, physiology [Transcription Factors], Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Cell biology, PPAR gamma, Blot, Psychiatry and Mental health, Clinical Psychology, physiology [Down-Regulation], chemistry, Nuclear receptor, Cell culture, Female, Geriatrics and Gerontology, metabolism [Alzheimer Disease], Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67bf72c200043cf12605375d12a9d39Test
https://doi.org/10.3233/jad-2011-101356Test

المؤلفون: Rudi D'Hooge, Bart De Strooper, Marta Ciesielska, Stefan F. Lichtenthaler, Ina Tesseur, Joris H. De Maeyer, Jan A.J. Schuurkes, Anna A. Pimenova, Adrian C. Lo

المصدر: Neurobiology of aging 34(7), 1779-1789 (2013). doi:10.1016/j.neurobiolaging.2013.01.020

مصطلحات موضوعية: Agonist, Aging, medicine.medical_specialty, medicine.drug_class, pharmacology [Serotonin Receptor Agonists], antagonists & inhibitors [Amyloid beta-Peptides], metabolism [Amyloid beta-Peptides], Mice, Transgenic, Stimulation, Presenilin, Amyloid beta-Protein Precursor, Mice, Alzheimer Disease, Internal medicine, biosynthesis [Amyloid beta-Peptides], Presenilin-1, medicine, Amyloid precursor protein, drug therapy [Alzheimer Disease], antagonists & inhibitors [Amyloid beta-Protein Precursor], Animals, Humans, metabolism [Receptors, Serotonin, 5-HT4], ddc:610, Receptor, Amyloid beta-Peptides, Prucalopride, biology, General Neuroscience, enzymology [Alzheimer Disease], genetics [Presenilin-1], biosynthesis [Amyloid beta-Protein Precursor], medicine.disease, Serotonin Receptor Agonists, therapeutic use [Serotonin Receptor Agonists], Mice, Inbred C57BL, Endocrinology, Alpha secretase, genetics [Amyloid beta-Protein Precursor], biology.protein, Receptors, Serotonin, 5-HT4, Neurology (clinical), Geriatrics and Gerontology, Alzheimer's disease, metabolism [Alzheimer Disease], Developmental Biology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb8ea70104bc0decbf70a30ab641834Test
https://doi.org/10.1016/j.neurobiolaging.2013.01.020Test

المؤلفون: Mark A. Hancock, Francois Charron, Dietmar Schmitz, Paul Dembny, Shireen Hossain, Peter W. Hildebrand, Yong Rao, Jürgen P. Rabe, Philip K.-Y. Chang, Heiko J. Bittner, Gerhard Multhaup, Rudi Lurz, Christian Barucker, Hunter Shaw, Wei Zhuang, Manuel Gensler, R. Anne McKinney, Anja Harmeier, Filip Liebsch, Scott A. Cameron

المصدر: Scientific reports 5(1), 15410 (2015). doi:10.1038/srep15410
Scientific Reports

مصطلحات موضوعية: antagonists & inhibitors [Amyloid beta-Peptides], antagonists & inhibitors [Peptide Fragments], Peptide, Protein aggregation, Synaptic Transmission, pathology [Alzheimer Disease], drug therapy [Alzheimer Disease], metabolism [Peptide Fragments], chemistry.chemical_classification, drug effects [Synaptic Transmission], education.field_of_study, Oligopeptide, Multidisciplinary, pharmacology [Oligopeptides], Long-term potentiation, amyloid beta-protein (1-42), Cell biology, Biochemistry, Alzheimer's disease, Function and Dysfunction of the Nervous System, Oligopeptides, metabolism [Alzheimer Disease], pathology [Synapses], Amyloid, Population, metabolism [Amyloid beta-Peptides], Neurotransmission, Biology, Protein Aggregation, Pathological, Article, pathology [Protein Aggregation, Pathological], metabolism [Protein Aggregation, Pathological], Alzheimer Disease, mental disorders, medicine, Animals, Rats, Wistar, education, Amyloid beta-Peptides, drug therapy [Protein Aggregation, Pathological], fungi, metabolism [Synapses], medicine.disease, Peptide Fragments, Rats, nervous system diseases, nervous system, chemistry, Synapses, ddc:600

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae9f902bdd35b65429bb05722134beaTest
https://doi.org/10.1038/srep15410Test

المؤلفون: Thomas Koeglsperger, Dennis J. Selkoe, Ming Jin, Ting Yang, Hongjun Fu, Shaomin Li, Dainan Zhang

المصدر: Neuron 77(5), 929-941 (2013). doi:10.1016/j.neuron.2012.12.040

مصطلحات موضوعية: Dendritic spine, drug effects [Hippocampus], Patch-Clamp Techniques, Long-Term Potentiation, antagonists & inhibitors [Amyloid beta-Peptides], glutamate receptor ionotropic, AMPA 1, Hippocampus, Hippocampal formation, Mice, 0302 clinical medicine, Cytosol, 0303 health sciences, Microscopy, Confocal, General Neuroscience, Long-term potentiation, Human brain, Immunohistochemistry, drug effects [Electrophysiological Phenomena], medicine.anatomical_structure, physiology [Synaptosomes], genetics [Receptors, AMPA], Signal transduction, Signal Transduction, physiology [Receptors, AMPA], Agonist, drug effects [Excitatory Postsynaptic Potentials], drug effects [Signal Transduction], medicine.drug_class, Dendritic Spines, Neuroscience(all), Blotting, Western, Biology, Environment, In Vitro Techniques, Article, 03 medical and health sciences, Physical Conditioning, Animal, medicine, Animals, Humans, drug effects [Receptors, Adrenergic, beta-2], ddc:610, Receptors, AMPA, pharmacology [Adrenergic beta-2 Receptor Agonists], Adrenergic beta-2 Receptor Agonists, drug effects [Dendritic Spines], 030304 developmental biology, Environmental enrichment, Amyloid beta-Peptides, physiology [Receptors, Adrenergic, beta-2], Excitatory Postsynaptic Potentials, Electrophysiological Phenomena, Mice, Inbred C57BL, pharmacology [Amyloid beta-Peptides], drug effects [Long-Term Potentiation], drug effects [Synaptosomes], chemistry [Amyloid beta-Peptides], metabolism [Cytosol], Receptors, Adrenergic, beta-2, Neuroscience, 030217 neurology & neurosurgery, Synaptosomes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda3bb10a51c75b56b7efb5bfcc78996Test
https://pub.dzne.de/record/136838Test

المؤلفون: Nampally Sreenivasachary, Paolo Paganetti, Valérie Giriens, Luitgard Nagel-Steger, Markus Zweckstetter, Oskar Adolfsson, Andreas Muhs, Heiko Kroth, Maria Pihlgren, Andrea Pfeifer, Thomas Schrader, Sophie Lohmann, Yvan Varisco, Asad Jan, Nasrollah Rezaei-Ghaleh, María Pilar López-Deber, Annalisa Ansaloni, Hilal A. Lashuel, Wolfgang Froestl, Dieter Willbold

المصدر: Journal of Biological Chemistry
The journal of biological chemistry 287(41), 34786-34800 (2012). doi:10.1074/jbc.M112.357665
Kroth, H, Ansaloni, A, Varisco, Y, Jan, A, Sreenivasachary, N, Rezaei-Ghaleh, N, Giriens, V, Lohmann, S, López-Deber, M P, Adolfsson, O, Pihlgren, M, Paganetti, P, Froestl, W, Nagel-Steger, L, Willbold, D, Schrader, T, Zweckstetter, M, Pfeifer, A, Lashuel, H A & Muhs, A 2012, ' Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation ', The Journal of biological chemistry, vol. 287, no. 41, pp. 34786-800 . https://doi.org/10.1074/jbc.M112.357665Test

مصطلحات موضوعية: 3-aminopyrazole, antagonists & inhibitors [Amyloid beta-Peptides], antagonists & inhibitors [Cytotoxins], antagonists & inhibitors [Peptide Fragments], Chemie, chemistry [Cytotoxins], Protein aggregation, Biochemistry, Protein Structure, Secondary, Hydrophobic effect, Structure-Activity Relationship, Protein structure, Cell Line, Tumor, mental disorders, Journal Article, Humans, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Cytotoxins, Chemistry, Research Support, Non-U.S. Gov't, In vitro toxicology, Molecular Bases of Disease, Hydrogen Bonding, Cell Biology, amyloid beta-protein (1-42), Small molecule, Peptide Fragments, Amino acid, chemistry [Peptide Fragments], ddc:540, chemistry [Pyrazoles], Pyrazoles, chemistry [Amyloid beta-Peptides], Hydrophobic and Hydrophilic Interactions, Linker

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f1d6b8bb6eb1e9cd8d68fd89416ac0Test
https://hdl.handle.net/11858/00-001M-0000-000E-7305-311858/00-001M-0000-000E-7304-511858/00-001M-0000-000E-7300-DTest