المؤلفون: Chen Zhang, Maoyu Wang, Yidie Ying, Fang Meng, Hongliang Gao, Shuxiong Zeng, Yasheng Zhu, Anwei Liu, Zhensheng Zhang, Chuanliang Xu

المصدر: Cancer Medicine, Vol 12, Iss 11, Pp 12581-12592 (2023)

مصطلحات موضوعية: AKT serine/threonine kinase, kinesin family member 4A, urothelial bladder carcinoma, Yes1 associated transcriptional regulator, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-7634Test

الوصول الحر: https://doaj.org/article/c5b961df02014e63a1cd53c9f1884180Test

المؤلفون: Hafiz Muhammad Ahmad, Muhammad Abrar, Osheen Izhar, Imran Zafar, Mohd Ashraf Rather, Amer M. Alanazi, Abdul Malik, Ahmar Rauf, Mashooq A. Bhat, Tanveer A. Wani, Azmat Ali Khan

المصدر: Journal of King Saud University: Science, Vol 34, Iss 6, Pp 102186- (2022)

مصطلحات موضوعية: Docking analyses, AutoDock Vina, AKT serine/threonine kinase, Virtual screening, Pharmacophore modeling, Anticancer, Science (General), Q1-390

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1018364722003676Test; https://doaj.org/toc/1018-3647Test

الوصول الحر: https://doaj.org/article/9bbca7777eb045e298857fd509b4d9eeTest

المؤلفون: Nicola Bougen-Zhukov, Lyvianne Decourtye-Espiard, Wilson Mitchell, Kieran Redpath, Jacqui Perkinson, Tanis Godwin, Michael A. Black, Parry Guilford

المصدر: Cancers; Volume 14; Issue 7; Pages: 1609

مصطلحات موضوعية: HDGC, E-cadherin, lobular breast cancer, diffuse gastric cancer, synthetic lethality, chemoprevention, dasatinib, AKT serine/threonine kinase 3 AKT3, discoidin domain receptor 2 (DDR2)

وصف الملف: application/pdf

العلاقة: Molecular Cancer Biology; https://dx.doi.org/10.3390/cancers14071609Test

الإتاحة: https://doi.org/10.3390/cancers14071609Test

المؤلفون: Olive P Khaliq, Saravanakumar Murugesan, Jagidesa Moodley, Irene Mackraj

المصدر: Clinical and Experimental Hypertension, Vol 40, Iss 8, Pp 744-751 (2018)

مصطلحات موضوعية: mirnas, preeclampsia, gestational hypertension, akt-serine, phosphatidyl-inositol-3, Diseases of the circulatory (Cardiovascular) system, RC666-701

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1064-1963Test; https://doaj.org/toc/1525-6006Test

الوصول الحر: https://doaj.org/article/7393da5656cf428b9694eecd09c8700aTest

المؤلفون: Taylor A. Harper, Silvia M. Bacot, Christie Jane Fennell, Rebecca L. Matthews, Christina Zhu, Peng Yue, Alexander Benton, Devira Friedman, Adovi Akue, Mark A. KuKuruga, Shiowjen Lee, Tao Wang, Gerald M. Feldman

المصدر: International Journal of Molecular Sciences; Volume 22; Issue 21; Pages: 11848

مصطلحات موضوعية: nivolumab, interleukin 10, T cells, cytokines, STAT3 pathway, AKT serine–threonine kinase pathway, MAP kinase pathway

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Molecular Oncology; https://dx.doi.org/10.3390/ijms222111848Test

الإتاحة: https://doi.org/10.3390/ijms222111848Test

المؤلفون: Bo Tang, Cunjie Chang, Guo Chen, Xiufeng Liu, Zi-Chun Hua, Xiawei Cheng, Jianxiang Chen, Heng Dong, Yiting Qiao

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3165-3177 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PEI, polyethylenimine, NF-κB, PCR, polymerase chain reaction, 0302 clinical medicine, Salmonella, Cancer immune therapy, IFN-γ, interferon-γ, General Pharmacology, Toxicology and Pharmaceutics, TLR5, IL, interleukins, IκB, inhibitor of NF-κB, GFP, green fluorescent protein, 0303 health sciences, PD-1, programmed cell death protein-1, TIR, Toll/Interleukin-1 receptor, TME, tumor microenvironment, DN, dominant-negative, Acquired immune system, AKT, Akt serine/threonine kinase, LRR, leucine-rich repeat, PD-L1, programmed cell death-ligand 1, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, LPS, lipopolysaccharide, Original Article, TLR, Toll-like receptor, TRAF6, TNF receptor associated factor 6, CTLA-4, cytotoxic T-lymphocyte-associated protein 4, PBS, phosphate-buffered saline, ERKl, extracellular regulated protein kinase 1, RM1-950, Biology, CFU, colony-forming units, 03 medical and health sciences, Immune system, MyD88, myeloid differentiation factor 88, i.t., intratumorally, 030304 developmental biology, Tumor microenvironment, Flagellum, Innate immune system, Pathogen-associated molecular pattern, i.p., intraperitoneally, Immune checkpoint, NF-κB, nuclear factor kappa-B, Granzyme, ERBB2, Erb-B2 receptor tyrosine kinase 2, Cancer research, biology.protein, bacteria, Bacteria-mediated cancer therapy, Therapeutics. Pharmacology, VNP20009, Flagellin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa58001e49d3f5032ed52d1763576536Test
https://doi.org/10.1016/j.apsb.2021.04.019Test

المؤلفون: Meidan Ying, Xuejing Shao, Hong Zhu, Ji Cao, Bo Yang, Yifan Chen, Qiaojun He

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: SRC-3, nuclear receptor coactivator 3, VHL, von Hippel-Lindau tumor suppressor, RRM2, ribonucleotide reductase regulatory subunit M2, KRAS, KRAS proto-oncogene, GTPase, SNAIL1, snail family transcriptional repressor 1, medicine.medical_treatment, CRL, cullin-RING ligase, ERK, mitogen-activated protein kinase 1, NEDD8, NEDD8 ubiquitin like modifier, Review, medicine.disease_cause, JAB1, c-Jun activation domain binding protein-1, p130Cas, BCAR1 scaffold protein, Cas family member, law.invention, Targeted therapy, Degradation, 0302 clinical medicine, Ubiquitin, law, RA, retinoic acid, FBXL3, F-box and leucine rich repeat protein, Ci, cubitus interruptus, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Crosstalk, FBXO3/31, F-box protein 3/31, 0303 health sciences, biology, KEAP1, kelch like ECH associated protein 1, Kinase, Chemistry, KBTBD8, kelch repeat and BTB domain containing 8, CSN, COP9 signalosome, DYRK1A/B, dual-specificity tyrosine-phosphorylation-regulated kinases 1A/B, FBW7, F-box and WD repeat domain containing 7, CDT2, denticleless E3 ubiquitin protein ligase homolog, NRF2, nuclear factor, erythroid 2 like 2, TCN, triciribine hydrate, Cell biology, USP37, ubiquitin specific peptidase 37, Crosstalk (biology), XBP1, X-box binding protein 1, 030220 oncology & carcinogenesis, HCC, hepatocellular carcinomas, Vps34, phosphatidylinositol 3-kinase catalytic subunit type 3, CK1/2, casein kinase I/II, COMMD1, copper metabolism domain containing 1, KLHL3, kelch like family member 3, EMT, epithelial–mesenchymal transition, Cullin, P-TEFb, positive transcription elongation factor b, CDK2/4, cyclin dependent kinase 2/4, SPOP, speckle-type POZ protein, AIRE, autoimmune regulator, PYGO2, pygopus 2, TCOF1, treacle ribosome biogenesis factor 1, ID2, inhibitor of DNA binding 2, CHK1, checkpoint kinase 1, Kinases, FZR1, fizzy and cell division cycle 20 related 1, HIF1α, NF-κB and hypoxia inducible factor 1 subunit alpha, EXO1, exonuclease 1, ZBTB16, zinc finger and BTB domain containing 16, NOLC1, nucleolar and coiled-body phosphoprotein 1, 03 medical and health sciences, PKM2, pyruvate kinase M2 isoform, KDM2B, lysine demethylase 2B, PKC, protein kinase C, Cullin-RING ligases, medicine, BMAL1, aryl hydrocarbon receptor nuclear translocator like, ATR, ataxia telangiectasia-mutated and Rad3-related, SOCS6, suppressor of cytokine signaling 6, 030304 developmental biology, PDL1, programmed death ligand 1, HIB, Hedghog-induced MATH and BTB domain-containing protein, AKT, AKT serine/threonine kinase, lcsh:RM1-950, Ubiquitination, TRF1, telomeric repeat binding factor 1, DDB1, damage specific DNA binding protein 1, BCL2, BCL2 apoptosis regulator, CLOCK, clock circadian regulator, MYC, MYC proto-oncogene, bHLH transcription factor, lcsh:Therapeutics. Pharmacology, c-Fos, Fos proto-oncogene, AP-1 transcription factor subunit, RARα, RA receptor α, Tumorigenesis, biology.protein, Suppressor, CRY1, cryptochrome circadian regulator 1, ERG, ETS transcription factor ERG, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722dTest
https://doi.org/10.1016/j.apsb.2020.09.007Test

المؤلفون: Wolfgang Walther, Annika Wulf-Goldenberg, Ulrike Stein, Johannes Merk, Iduna Fichtner, Keziban M. Alp, Giannino Patone, Tamara Kanashova, Christine Sers, Philipp Mertins, Maria Rivera, Jens Hoffmann

المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)

مصطلحات موضوعية: Proteomics, 0301 basic medicine, Cancer Research, Proteome, Colorectal cancer, Fluorescent Antibody Technique, TP53, tumor protein p53, Proto-Oncogene Mas, EREG, epiregulin, Metastasis, Mice, 0302 clinical medicine, BTC, betacellulin, Molecular Targeted Therapy, Epidermal growth factor receptor, Precision Medicine, biology, Cetuximab, GCN, gene copy number, TDT, tumor doubling time, APC, adenomatous polyposis coli, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Primary tumor, Colorectal carcinoma, EpCAM, epithelial cell adhesion molecule, 030220 oncology & carcinogenesis, CRC, colorectal cancer, BRAF, proto-oncogene B-RAF, Heterografts, AKT, Serine threonine protein kinase AKT, Erlotinib, AREG, Amphiregulin, Technology Platforms, Colorectal Neoplasms, TNM, tumor nodule metastasis classification, medicine.drug, Original article, endocrine system, DNA Copy Number Variations, TGFα, transforming growth factor alfa, In vivo drug testing, Antineoplastic Agents, KRAS, Kirsten rat sarcoma virus oncogene homolog, mTOR, mammalian target of rapamycin, PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinaseM catalytic subunit alfa, lcsh:RC254-282, Genomic Instability, NSG mice, NOD scid gamma mice, 03 medical and health sciences, PDX, patient derived xenograft, Biomarkers, Tumor, medicine, Animals, Humans, IHC, imunno histochemistry, neoplasms, FFPE, formalin fixed paraffin embedded, EGF, epidermal growth factor, Betacellulin, Oncogene, business.industry, Gene Expression Profiling, medicine.disease, Xenograft Model Antitumor Assays, Personalized medicine, c-MET, tyrosine protein kinase MET, digestive system diseases, EGFR, epidermal growth factor receptor, 030104 developmental biology, Drug Resistance, Neoplasm, Patient-derived xenograft models, T/C, treated to control value, Mutation, Cancer research, biology.protein, 5-FU, 5-fluorouracil, HER2,3,4, human epidermal growth factor receptor 2,3,4, business, MAPK, mitogen activated protein kinase

وصف الملف: application/pdf; application/msword

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8082ec6c5f41c16d128a521a50759417Test
https://doi.org/10.1016/j.neo.2020.11.005Test

المؤلفون: Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)

مصطلحات موضوعية: LDH, lactic dehydrogenase, MMP, mitochondrial membrane potential, Hepatocellular carcinoma, 7-AAD, 7-aminoactinomycin D, NS, no significance, TBST, Tris-buffered saline with Tween solution, DMSO, dimethyl sulfoxide, ECL, enhanced chemiluminescence, NC, negative control, 0302 clinical medicine, GSDME, gasdermin E, General Pharmacology, Toxicology and Pharmaceutics, N-GSDME, N-terminal GSDME, PARP, poly ADP-ribose polymerase, Caspase, ANOVA, analysis of variance, p-MEK, phosphorylated-MEK, DCFH-DA, dye 2,7-dichlorofluoresce diacetate, MEK, mitogen-activated and extracellular signal-regulated kinase, 0303 health sciences, DMEM, Dulbecco's modified Eagle's medium, biology, Kinase, Chemistry, Pyroptosis, HRP, horseradish peroxidase, PI3K, phosphatidylinositol 3-kinase, gRNA, guide RNA, i.p., intraperitoneal, VEGF, vascular endothelial growth factor, PBS, phosphate-based buffer, SDS-PAGE, sodium dodecyl sulphate-polyacrylamide gel electrophoresis, CRISPR, clustered regularly interspaced short palindromic repeats, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, Original Article, FITC, fluorescein isothiocyanate, RIPA, radioimmunoprecipitation assay, p-AKT, phosphorylated-AKT, IgG (H + L), immunoglobulin G (heavy chain + light chain), Intracellular, Cell death, Programmed cell death, HepG2, Miltirone, TCGA, the Cancer Genome Atlas, p-ERK1/2, phosphorylated-ERK1/2, Caspase 3, IC50, the half maximal inhibitory concentration, mTOR, mammalian target of rapamycin, MEM, minimum essential medium, PI, propidium iodide, 03 medical and health sciences, CCK-8, cell counting kit-8, ROS, reactive oxygen species, FBS, fetal bovine serum, i.v., intravenous, Viability assay, GSDMD, gasdermin D, AKT, AKT serine/threonine kinase, also known as protein kinase B, NMR, nuclear magnetic resonance, Cas9, caspase 9, 030304 developmental biology, Hepa1-6, KO, knockout, lcsh:RM1-950, lcsh:Therapeutics. Pharmacology, BAX, BCL2-associated X, Apoptosis, NAC, N-acetyl cysteine, ERK1/2, extracellular regulated protein kinases 1/2, Cancer research, biology.protein, H&E, hematoxylin and eosin, GSDME, HCC, hepatocellular carcinoma, SD, standard deviation, MS, mass spectrum

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750fb5bad337ad6389f2c3000e4927a2Test
http://europepmc.org/articles/PMC7488361Test

المؤلفون: Jifa Zhang, Bo Liu, Liang Ouyang, Honggang Xiang, Congcong Lin, Lan Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 569-581 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PINK1, PTEN-induced putative kinase 1, Review, PROTAC, proteolysis targeting chimeras, PTMs, post-translational modifications, Protein aggregation, PKCα, protein kinase C alpha type, AKT1, AKT serine/threonine kinase 1, PD, Parkinson's disease, Autophagy-related kinase, DAPK, death associated protein kinase, PKD1, polycystin-1, GAP, GTPase-activating protein, PKACα, a protein kinase cAMP-activated catalytic subunit alpha, 0302 clinical medicine, Human disease, TNBC - Triple-negative breast cancer, Protein kinases, LC3, microtubule-associated protein 1 light chain 3, UVRAG, ultraviolet resistance-associated gene, TFEB, transcription factor EB, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Rheb, the RAS homolog enriched in brain, TAK1, transforming growth factor activated kinase-1, 0303 health sciences, Kinase, mTORC1, mammalian target of rapamycin complex 1, PI3 kinase, phosphoinositide 3-kinase, Cell biology, GSK3α, glycogen synthase kinase 3 alpha, HMGB1, high mobility group protein B1, AMBRA1, autophagy/beclin-1 regulator 1, ULK complex, ULK1–mATG13–FIP200–ATG101 complex, ARF, auxin response factor gene, 030220 oncology & carcinogenesis, TSC1/2, tuberous sclerosis complex proteins 1/2, PIM2, proviral insertion in murine lymphomas 2, LPS, lipopolysaccharide, PI3P, phosphatidylinositol triphosphate, Small-molecule kinase inhibitors/activators, JNK1, C-Jun N-terminal kinase, mTOR, mammalian target of rapamycin, ULK1, unc-51-like kinase 1, Biology, PPIs, protein–protein interactions, PI, phosphatidylinositol, TNBC, triple-negative breast cancer, FIP200, FAK family kinase-interacting protein of 200 kDa, 03 medical and health sciences, 4E-BP1, eukaryotic translation initiation factor 4E-binding protein, Organelle, Autophagy, LRRK2, leucine rich repeat kinase 2, ATG, autophagy-related protein, GO, gene ontology, 030304 developmental biology, PD - Parkinson's disease, lcsh:RM1-950, CaMKK2, calcium/calmodulin-dependent protein kinase kinase 2, Human disease therapy, AMPK, AMP-activated protein kinase, lcsh:Therapeutics. Pharmacology, PIP2, phosphatidylinositol-4,5-bisphosphate, LKB1, serine/threonine-protein kinase stk11

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e45bf1ac401222740c4f8e78dae670Test
http://www.sciencedirect.com/science/article/pii/S221138351930276XTest