دورية أكاديمية
Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes
| العنوان: | Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes |
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| المؤلفون: | Peter Pajtinka, Robert Vácha |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Sociology, Science Policy, Biological Sciences not elsewhere classified, Physical Sciences not elsewhere classified, positive membrane curvature, negative membrane curvature, specific curvature, positive curvature, curvature preference, thereby adjusting, preferentially localize, packing defects, negative curvatures, insertion depth, gradually tuned, exploit lipid, amphipathic helices, alternative framework, ah sensing |
| الوصف: | Curvature sensing is an essential ability of biomolecules to preferentially localize to membrane regions of a specific curvature. It has been shown that amphipathic helices (AHs), helical peptides with both hydrophilic and hydrophobic regions, could sense a positive membrane curvature. The origin of this AH sensing has been attributed to their ability to exploit lipid-packing defects that are enhanced in regions of positive curvature. In this study, we revisit an alternative framework where AHs act as sensors of local internal stress within the membrane, suggesting the possibility of an AH sensing a negative membrane curvature. Using molecular dynamics simulations, we gradually tuned the hydrophobicity of AHs, thereby adjusting their insertion depth so that the curvature preference of AHs is switched from positive to negative. This study suggests that highly hydrophobic AHs could preferentially localize proteins to regions of a negative membrane curvature. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://figshare.com/articles/journal_contribution/Amphipathic_Helices_Can_Sense_Both_Positive_and_Negative_Curvatures_of_Lipid_Membranes/24913285Test |
| DOI: | 10.1021/acs.jpclett.3c02785.s001 |
| الإتاحة: | https://doi.org/10.1021/acs.jpclett.3c02785.s001Test https://figshare.com/articles/journal_contribution/Amphipathic_Helices_Can_Sense_Both_Positive_and_Negative_Curvatures_of_Lipid_Membranes/24913285Test |
| حقوق: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.CF67F88B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acs.jpclett.3c02785.s001 |
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