المؤلفون: Mohammad Fallahi‐Sichani, Verena Becker, Benjamin Izar, Gregory J Baker, Jia‐Ren Lin, Sarah A Boswell, Parin Shah, Asaf Rotem, Levi A Garraway, Peter K Sorger

المصدر: Molecular Systems Biology, Vol 13, Iss 1, Pp n/a-n/a (2017)

مصطلحات موضوعية: adaptive and reversible drug resistance, BRAFV600E melanomas, de‐differentiated NGFRHigh state, RAF and MEK inhibitors, Biology (General), QH301-705.5, Medicine (General), R5-920

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1744-4292Test

الوصول الحر: https://doaj.org/article/0e7952fd9cd14e07ad39e72e947a9f95Test

المؤلفون: Fallahi‐Sichani, Mohammad, Becker, Verena, Izar, Benjamin, Baker, Gregory J, Lin, Jia‐Ren, Boswell, Sarah A, Shah, Parin, Rotem, Asaf, Garraway, Levi A, Sorger, Peter K

مصطلحات موضوعية: Article, adaptive and reversible drug resistance, de‐differentiated NGFR, Molecular Biology of Disease, Quantitative Biology & Dynamical Systems, Signal Transduction

وصف الملف: application/pdf

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248573/pdfTest/; Molecular Systems Biology; Fallahi‐Sichani, Mohammad, Verena Becker, Benjamin Izar, Gregory J Baker, Jia‐Ren Lin, Sarah A Boswell, Parin Shah, Asaf Rotem, Levi A Garraway, and Peter K Sorger. 2017. “Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state.” Molecular Systems Biology 13 (1): 905. doi:10.15252/msb.20166796. http://dx.doi.org/10.15252/msb.20166796Test.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371094Test

الإتاحة: https://doi.org/10.15252/msb.20166796Test
http://nrs.harvard.edu/urn-3:HUL.InstRepos:30371094Test

المؤلفون: Sarah A. Boswell, Asaf Rotem, Benjamin Izar, Jia-Ren Lin, Gregory J. Baker, Mohammad Fallahi-Sichani, Verena Becker, Peter K. Sorger, Parin Shah, Levi A. Garraway

المساهمون: Broad Institute of MIT and Harvard, Garraway, Levi

المصدر: European Molecular Biology Organization (EMBO)
Molecular Systems Biology

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Indoles, Cellular differentiation, BRAFV600E melanomas, Proto-Oncogene Proteins B-raf, Mice, Molecular Biology of Disease, Melanoma, Quantitative Biology & Dynamical Systems, Sulfonamides, Kinase, Applied Mathematics, Cell Differentiation, Articles, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, Cell killing, Computational Theory and Mathematics, Signal transduction, Single-Cell Analysis, General Agricultural and Biological Sciences, Information Systems, Proto-oncogene tyrosine-protein kinase Src, Signal Transduction, Cell Survival, MAP Kinase Signaling System, Nerve Tissue Proteins, Receptors, Nerve Growth Factor, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Cell Proliferation, General Immunology and Microbiology, Cell growth, Gene Expression Profiling, adaptive and reversible drug resistance, Xenograft Model Antitumor Assays, 030104 developmental biology, Vemurafenib, Drug Resistance, Neoplasm, Mutation, RAF and MEK inhibitors, de‐differentiated NGFRHigh state

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7994e8b553e89cba3ee4a5cb14a72f84Test
http://hdl.handle.net/1721.1/109938Test