Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Pathology
| العنوان: | Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Pathology |
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| المؤلفون: | Richard Poulsom, Hartmut Koeppen, Philip J. Coates, C. Simon Herrington |
| المصدر: | Herrington, C S, Poulsom, R, Koeppen, H & Coates, P J 2021, ' Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Path ', Journal of Pathology . https://doi.org/10.1002/path.5687Test |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | mitochondrial pathology, Pathology, Research areas, Disease, migration, chromatin modification, 0302 clinical medicine, HDAC inhibitors, oncogene, severe actute reisparatory syndrome coronovirus 2 (SARS-CoV-2), therapeutic discovery, tumour microenviroment, GWAS, genetics, tumour-infiltrating lymphocytes, pathophysiology, Smad, spatial transcriptomics, local microbiota, Respiratory infection, Genomics, Biobank, macrophages, Organoids, mitochondrial disease, imilimumab, 030220 oncology & carcinogenesis, nephroblastoma, pembrolizumab, stretch, atezolizumab, medicine.medical_specialty, cancer stem cells (CSCs), mouse model, human genetics, shear stress, Pathology and Forensic Medicine, TGF-B, genetic diagnosis, 03 medical and health sciences, proteomics, MDM2, stem cells, squamous cell cancer, genomics, Humans, Subject areas, single cell transcriptomes, microbial toxins, nivolumab, gene enhancers, mmunopathology, cellular crosstalk, Precision medicine, MAPK, ioiopathic pulmonary birosis, 030104 developmental biology, CSC niche, soft tissue, p53, 0301 basic medicine, microbial metabolites, History, multiplex immunohistochemistry, sarcome, microbiome, bone, stiffness, Neoplasms, profibrotic, TIF1beta, epithelial to mesenchymal transition (EMT), Wilms' tumour, organoids, p63, treatment, autoimmunity, phagocytosis, dysbiosis, intratumoral microbiota, metabolomics, humanities, inflmamation, acute resiparatory distress syndrome (ARDS), KAP1, mTOR, immunotherapy, 3D culture, PD-L1, tumour suppressor, extracellular matrix, precision medicine, microstructure, cancer predisposition, PD01, Translational research, medicine, cancer, angiotensin-converting enzyme 2 (ACE2), damage-associated molecular patterns, immuno-oncology, polarization, therapy, endothelial to mesenchymal transition (endMT), epigenetics, SARS-CoV-2, TRIM28, antifibrotic, COVID-19, cell of origin, cancer progression, United Kingdom, multiplex in situe hybridization, Transplantation, tumorigenesis, polygenic risk score, IL-33, pathology, coronavirus diseas 2019 (COVID-19) |
| الوصف: | The 2021 Annual Review Issue of The Journal of Pathology contains 14 invited reviews on current research areas of particular importance in pathology. The subjects included here reflect the broad range of interests covered by the journal, including both basic and applied research fields but always with the aim of improving our understanding of human disease. This year, our reviews encompass the huge impact of the COVID-19 pandemic, the development and application of biomarkers for immune checkpoint inhibitors, recent advances in multiplexing antigen/nucleic acid detection in situ, the use of genomics to aid drug discovery, organoid methodologies in research, the microbiome in cancer, the role of macrophage-stroma interactions in fibrosis, and TGF-β as a driver of fibrosis in multiple pathologies. Other reviews revisit the p53 field and its lack of clinical impact to date, dissect the genetics of mitochondrial diseases, summarise the cells of origin and genetics of sarcomagenesis, provide new data on the role of TRIM28 in tumour predisposition, review our current understanding of cancer stem cell niches, and the function and regulation of p63. The reviews are authored by experts in their field from academia and industry, and provide comprehensive updates of the chosen areas, in which there has been considerable recent progress. © 2021 The Pathological Society of Great Britain and Ireland. Published by John WileySons, Ltd. |
| وصف الملف: | application/pdf |
| تدمد: | 1096-9896 0022-3417 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a2683cce62a47fe3c9c1c3a6cdb89aTest https://doi.org/10.1002/path.5687Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b5a2683cce62a47fe3c9c1c3a6cdb89a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969896 00223417 |
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