المؤلفون: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene, Zink, Florence

العلاقة: Michellys, Pierre-Yves, Pei, Wei, Zhang, Yi, Jiang, Tao, Han, Dong, Zhang, Guobao, Chang, Dai, Alper, Phillip, Mutnick, Daniel, Deane, Jonathan, Syka, Peter, Maginnis, Jillian, Junt, Tobias, Knoepfel, Thomas, Betschart, Claudia, Glatthar, Ralf, Feifel, Roland, Faller, Michael, Hemmig, Rene and Zink, Florence (2023) Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases. ACS medicinal chemistry letters, 14 (8). pp. 1054-1062. ISSN 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00136Test
https://oak.novartis.com/48414Test/
https://urldefense.com/v3/__https://pubs.acs.org/articlesonrequest/AOR-XMSQJCAESAJE7ANDBGJR__;!!N3hqHg43uw!uFA3uM4olcCL8tpKCJYXYyL3M18AlqJHvL11w9Hn1C8hAOd_Qr-Gh2R1bCZu3OuuUBvMawz8PHcn3D4u2P0BKWejMgTest$

المؤلفون: Rothman, Alex M, Florentin, Amir, Quigley, Catherine, Zink, Florence, Bonneau, Olivier, Hemming, Rene, Hachey, Amanda, Rejtar, Tomas, Thaker, Maulik, Jain, Rishi, Zhang, Ji-Hu, Cotesta, Simona, Ottl, Johannes, Kordinsky, Alina, Avishid, Reut, Troxler, Thomas, Binmahfooz, Sarah K, Morrell, Nicholas W, Humbert, Marc, Cobb, Jennifer, Osterman, Nils, Tallerico, John, Shaw, Duncan, Guth-Gundel, Sabine, Prag, Gali, Rowlands, David J

المصدر: Circulation ; volume 148, issue Suppl_1 ; ISSN 0009-7322 1524-4539

الإتاحة: https://doi.org/10.1161/circ.148.suppl_1.14275Test

المؤلفون: Alper, Phil, Betschart, Claudia, André, Cédric, Boulay, Thomas, Cheng, Dai, Deane, Jonathan, Faller, Michael, Feifel, Roland, Glatthar, Ralf, Han, Dong, Hemmig, Rene, Jiang, Tao, Knoepfel, Thomas, Maginnis, Jillian, Mutnick, Daniel, Pei, Wei, Ruzzante, Giulia, Syka, Peter, Zhang, Guobao, Zhang, Yi, Zink, Florence, Zipfel, Géraldine, Hawtin, Stuart, Junt, Tobias, Michellys, Pierre-Yves

المساهمون: Novartis

المصدر: ACS Medicinal Chemistry Letters ; volume 14, issue 8, page 1054-1062 ; ISSN 1948-5875 1948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00136Test

المؤلفون: Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim, Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel Alexander, Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaelle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne, Mura, Christophe, Sorge, Mickael, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Johannes, Zecri, Frederic, Sedrani, Richard, Ostermann, Nils, Brachmann, Saskia

العلاقة: Lorthiois, Edwige, Gerspacher, Marc, Beyer, Kim, Vaupel, Andrea, Leblanc, Catherine, Stringer, Rowan, Weiss, Andreas, Wilcken, Rainer, Guthy, Daniel Alexander, Lingel, Andreas, Bomio-Confaglia, Claudio, Machauer, Rainer, Rigollier, Pascal, Ottl, Johannes, Arz, Dorothee, Bernet, Pascal, Desjonqueres, Gaelle, Dussauge, Solene, Kazic-Legueux, Malika, Lozac'h, Marie-Anne, Mura, Christophe, Sorge, Mickael, Todorov, Milen, Warin, Nicolas, Zink, Florence, Voshol, Johannes, Zecri, Frederic, Sedrani, Richard, Ostermann, Nils and Brachmann, Saskia (2022) JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors. Journal of medicinal chemistry, 65 (24). pp. 16173-16203. ISSN 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.2c01438Test
https://oak.novartis.com/48106Test/

المؤلفون: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland, Knoepfel, Thomas

العلاقة: Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, Rene, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sebastien, Junt, Tobias, Collignon Zipfel, Geraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland and Knoepfel, Thomas (2022) Structure-based optimization of a fragment like TLR8 binding screening hit to an in vivo efficacious TLR7/8 antagonist. ACS Medicinal Chemistry Letters. ISSN 1948-58751948-5875

الإتاحة: https://doi.org/10.1021/acsmedchemlett.1c00696Test
https://oak.novartis.com/46530Test/

المؤلفون: Schutzius, Gabi, Hauer, Christian, Bergling, Sebastian, Tortelli, Federico, Fuchs, Florian, Renner, Steffen, Guagnano, Vito, Cotesta, Simona, Rueeger, Heinrich, Faller, Michael, Bouchez, Laure, Salathe, Adrian, Nigsch, Florian, Richards, Shola, Louis, Malvina Caroline, Gruber, Viktoria, Aebi, Alexandra, Turner, Jonathan, Grandjean, Frederic, Li, Jun, Dimitri, Christopher, Thomas, Jason, Schirle, Markus, Blank, Jutta, Drueckes, Peter, Vaupel, Andrea, Tiedt, Ralph, Manley, Paul, Klopp, Julia, Hemmig, Rene, Zink, Florence, Leroy, Nelly, Carbone, Walter, Roma, Guglielmo, Gubser Keller, Caroline, Dales, Natalie, Beyerbach, Armin, Zimmerlin, Alfred Gilbert, Bonenfant, Debora, Terranova, Remi, Berwick, Amy, Sahambi, Sukhdeep, Reynolds, Aimee, Jennings, Lori, Ruffner, Heinz, Tarsa, Peter, Bouwmeester, Antonius, Driver, Vickie, Frederiksen, Mathias, Lohmann, Felix, Kirkland, Susan

العلاقة: Schutzius, Gabi, Hauer, Christian, Bergling, Sebastian, Tortelli, Federico, Fuchs, Florian, Renner, Steffen, Guagnano, Vito, Cotesta, Simona, Rueeger, Heinrich, Faller, Michael, Bouchez, Laure, Salathe, Adrian, Nigsch, Florian, Richards, Shola, Louis, Malvina Caroline, Gruber, Viktoria, Aebi, Alexandra, Turner, Jonathan, Grandjean, Frederic, Li, Jun, Dimitri, Christopher, Thomas, Jason, Schirle, Markus, Blank, Jutta, Drueckes, Peter, Vaupel, Andrea, Tiedt, Ralph, Manley, Paul, Klopp, Julia, Hemmig, Rene, Zink, Florence, Leroy, Nelly, Carbone, Walter, Roma, Guglielmo, Gubser Keller, Caroline, Dales, Natalie, Beyerbach, Armin, Zimmerlin, Alfred Gilbert, Bonenfant, Debora, Terranova, Remi, Berwick, Amy, Sahambi, Sukhdeep, Reynolds, Aimee, Jennings, Lori, Ruffner, Heinz, Tarsa, Peter, Bouwmeester, Antonius, Driver, Vickie, Frederiksen, Mathias, Lohmann, Felix and Kirkland, Susan (2021) BET bromodomain inhibitors regulate keratinocyte plasticity. Nature Chemical Biology, 17 (3). pp. 280-290. ISSN 15524469

الإتاحة: https://doi.org/10.1038/s41589-020-00716-zTest
https://oak.novartis.com/38624Test/

المؤلفون: Thomson, Christopher G., Le Grand, Darren, Dowling, Mark, Beattie, David, Elphick, Lucy, Faller, Michael, Freeman, Mark, Hardaker, Elizabeth, Head, Victoria, Hemmig, Rene, Hill, Johan, Lister, Andrew, Pascoe, David, Rieffel, Sebastien, Shrestha, Binesh, Steward, Oliver, Zink, Florence

المصدر: Bioorganic & Medicinal Chemistry Letters ; volume 31, page 127663 ; ISSN 0960-894X

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Biology, Molecular Medicine, Biochemistry

الإتاحة: https://doi.org/10.1016/j.bmcl.2020.127663Test
https://api.elsevier.com/content/article/PII:S0960894X20307745?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0960894X20307745?httpAccept=text/plainTest

المؤلفون: Thomson, Christopher, Le Grand, Darren, Dowling, Mark, Beattie, David, Elphick, Lucy, Faller, Michael, Freeman, Mark, Hardaker, Elizabeth, Head, Victoria, Hemmig, Rene, Hill, Johan, Lister, Andrew, Pascoe, David, Rieffel, Sebastien, Shresta, Binesh, Steward, Oliver, Zink, Florence

العلاقة: Thomson, Christopher, Le Grand, Darren, Dowling, Mark, Beattie, David, Elphick, Lucy, Faller, Michael, Freeman, Mark, Hardaker, Elizabeth, Head, Victoria, Hemmig, Rene, Hill, Johan, Lister, Andrew, Pascoe, David, Rieffel, Sebastien, Shresta, Binesh, Steward, Oliver and Zink, Florence (2020) Development of autotaxin inhibitors: A series of tetrazole cinnamides. Bioorganic and medicinal chemistry letters. ISSN 0960894X

الإتاحة: https://doi.org/10.1016/j.bmcl.2020.127663Test
https://oak.novartis.com/41765Test/

المؤلفون: Salmeen, Kirsten, Block-Kurbisch, Ingrid, Zink, Florence, Shafer, Sherri, Cheng, Yvonne

المصدر: American Journal of Obstetrics and Gynecology ; volume 208, issue 1, page S124 ; ISSN 0002-9378

مصطلحات موضوعية: Obstetrics and Gynecology

الإتاحة: https://doi.org/10.1016/j.ajog.2012.10.437Test
https://api.elsevier.com/content/article/PII:S0002937812015207?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0002937812015207?httpAccept=text/plainTest

المؤلفون: Ostermann, Nils, Eder, Joerg, Eidhoff, Ulf, Zink, Florence, Hassiepen, Ulrich, Worpenberg-Pietruk, Susanne, Maibaum, Juergen Klaus, Simic, Oliver, Hommel, Ulrich, Gerhartz, Bernd

العلاقة: Ostermann, Nils, Eder, Joerg, Eidhoff, Ulf, Zink, Florence, Hassiepen, Ulrich, Worpenberg-Pietruk, Susanne, Maibaum, Juergen Klaus, Simic, Oliver, Hommel, Ulrich and Gerhartz, Bernd (2006) Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor. Journal of Molecular Biology, 355 (2). pp. 249-261. ISSN 0022-2836; PMID: 16305800

الإتاحة: https://oak.novartis.com/473Test/
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WK7-4HHGF15-5&_user=6433474&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000006118&_version=1&_urlVersion=0&_userid=6433474&md5=e02d6aae9195992fda232ffd0b39b603#implicit0Test