دورية أكاديمية
Golgi organization is regulated by proteasomal degradation
| العنوان: | Golgi organization is regulated by proteasomal degradation |
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| المؤلفون: | Eisenberg-Lerner, Avital, Benyair, Ron, Hizkiahou, Noa, Nudel, Neta, Maor, Roey, Kramer, Matthias P., Shmueli, Merav D., Zigdon, Inbal, Cherniavsky Lev, Marina, Ulman, Adi, Sagiv, Jitka Yehudith, Dayan, Molly, Dassa, Bareket, Rosenwald, Mercedes, Shachar, Idit, Li, Jie, Wang, Yanzhuang, Dezorella, Nili, Khan, Suman, Porat, Ziv, Shimoni, Eyal, Avinoam, Ori, Merbl, Yifat |
| المساهمون: | Israel Science Foundation, Council for Higher Education of Israel | Israeli Centers for Research Excellence |
| المصدر: | Nature Communications ; volume 11, issue 1 ; ISSN 2041-1723 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary |
| الوصف: | The Golgi is a dynamic organelle whose correct assembly is crucial for cellular homeostasis. Perturbations in Golgi structure are associated with numerous disorders from neurodegeneration to cancer. However, whether and how dispersal of the Golgi apparatus is actively regulated under stress, and the consequences of Golgi dispersal, remain unknown. Here we demonstrate that 26S proteasomes are associated with the cytosolic surface of Golgi membranes to facilitate Golgi Apparatus-Related Degradation (GARD) and degradation of GM130 in response to Golgi stress. The degradation of GM130 is dependent on p97/VCP and 26S proteasomes, and required for Golgi dispersal. Finally, we show that perturbation of Golgi homeostasis induces cell death of multiple myeloma in vitro and in vivo, offering a therapeutic strategy for this malignancy. Taken together, this work reveals a mechanism of Golgi-localized proteasomal degradation, providing a functional link between proteostasis control and Golgi architecture, which may be critical in various secretion-related pathologies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41467-019-14038-9 |
| الإتاحة: | https://doi.org/10.1038/s41467-019-14038-9Test https://www.nature.com/articles/s41467-019-14038-9.pdfTest https://www.nature.com/articles/s41467-019-14038-9Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.A8095C1C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-019-14038-9 |
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