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1دورية أكاديمية
المؤلفون: Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P. Golden, Katherine A. Donovan, Adam Bailey, Eric S. Fischer, Tinghu Zhang, Nathanael S. Gray, Priscilla L. Yang
المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2041-1723Test
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2دورية أكاديمية
المؤلفون: Zhengnian Li, Jie Jiang, Scott B. Ficarro, Tyler S. Beyett, Ciric To, Isidoro Tavares, Yingde Zhu, Jiaqi Li, Michael J. Eck, Pasi A. Jänne, Jarrod A. Marto, Tinghu Zhang, Jianwei Che, Nathanael S. Gray
المصدر: ACS Central Science, Vol 10, Iss 6, Pp 1156-1166 (2024)
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2374-7951Test
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3دورية أكاديمية
المؤلفون: Zhengnian Li, Wenchao Lu, Tyler S. Beyett, Scott B. Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A. Marto, Jianwei Che, Pasi A. Jänne, Michael J. Eck, Tinghu Zhang, Nathanael S. Gray
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Pharmacology, Cancer, Plant Biology, Computational Biology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, acrylamide side chain, flipped binding mode, alternative binding mode, based covalent probe, ribose binding pocket, substituted pyrazolopyrimidine binds, binding pocket, covalent bond, oriented toward, kinase inhibitors, heterocyclic core, findings suggest, conformation analogous, c3 position, analogues feature
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01891.s002Test
https://figshare.com/articles/journal_contribution/ZNL0325_a_Pyrazolopyrimidine-Based_Covalent_Probe_Demonstrates_an_Alternative_Binding_Mode_for_Kinases/25127274Test -
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المؤلفون: Sai Gourisankar, Andrey Krokhotin, Wenzhi Ji, Xiaofan Liu, Chiung-ying Chang, Samuel H. Kim, Zhengnian Li, Wendy Wenderski, Juste M. Simanauskaite, Tinghu Zhang, Nathanael S. Gray, Gerald R. Crabtree
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::138aaca5e330a190d857a45acf72b109Test
https://doi.org/10.1101/2022.12.04.517548Test -
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المؤلفون: Thomas W. Gero, David E. Heppner, Tyler S. Beyett, Ciric To, Seth C. Azevedo, Jaebong Jang, Thomas Bunnell, Frederic Feru, Zhengnian Li, Bo Hee Shin, Kara M. Soroko, Prafulla C. Gokhale, Nathanael S. Gray, Pasi A. Jänne, Michael J. Eck, David A. Scott
المصدر: Bioorganicmedicinal chemistry letters. 68
مصطلحات موضوعية: Lung Neoplasms, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, ErbB Receptors, Phenols, Drug Resistance, Neoplasm, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, Mutation, Molecular Medicine, Humans, Molecular Biology, Protein Kinase Inhibitors, Quinazolinones
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bfb1415ffe44876f18b0e35b149a21Test
https://pubmed.ncbi.nlm.nih.gov/35378251Test -
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المؤلفون: Guangyan Du, Jie Jiang, Nathaniel J. Henning, Nozhat Safaee, Eriko Koide, Radosław P. Nowak, Katherine A. Donovan, Hojong Yoon, Inchul You, Hong Yue, Nicholas A. Eleuteri, Zhixiang He, Zhengnian Li, Hubert T. Huang, Jianwei Che, Behnam Nabet, Tinghu Zhang, Eric S. Fischer, Nathanael S. Gray
المصدر: Cell Chemical Biology. 29:1470-1481.e31
مصطلحات موضوعية: Pharmacology, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Ubiquitin-Protein Ligases, Clinical Biochemistry, Ligands, Biochemistry, Mice, Focal Adhesion Protein-Tyrosine Kinases, Drug Discovery, Animals, Molecular Medicine, Ubiquitins, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd18917650df053c5eafa56606f1849aTest
https://doi.org/10.1016/j.chembiol.2022.08.003Test -
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المؤلفون: Zhengnian Li, Ryosuke Ishida, Yan Liu, Jinhua Wang, Yina Li, Yang Gao, Jie Jiang, Jianwei Che, Jason M. Sheltzer, Matthew B. Robers, Tinghu Zhang, Kenneth D. Westover, Behnam Nabet, Nathanael S. Gray
المصدر: European Journal of Medicinal Chemistry. 238:114433
مصطلحات موضوعية: Pharmacology, Structure-Activity Relationship, Cyclin-Dependent Kinase 2, Organic Chemistry, Drug Discovery, Apoptosis, Cell Cycle Checkpoints, General Medicine, Cyclin-Dependent Kinases
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d29f95f85ba5dd39b99b850dd4c2c4cTest
https://doi.org/10.1016/j.ejmech.2022.114433Test -
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المؤلفون: Nathanael S. Gray, Marc-Philipp Pfeil, Jinhua Wang, Wenlong Lian, Chih-Yun Hsia, Nicholas Kwiatkowski, Jaebong Jang, Priscilla L. Yang, Jared D. Pitts, Zhengnian Li
المصدر: Antiviral Research. 164:147-153
مصطلحات موضوعية: 0301 basic medicine, viruses, 030106 microbiology, Dengue virus, medicine.disease_cause, Antiviral Agents, Article, Zika virus, Small Molecule Libraries, 03 medical and health sciences, Viral Envelope Proteins, Viral envelope, Virology, Drug Discovery, medicine, Pharmacology, biology, Lipid bilayer fusion, Zika Virus, Dengue Virus, Virus Internalization, biology.organism_classification, Small molecule, Flavivirus, 030104 developmental biology, Vesicular stomatitis virus, Primary screening
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83f13e9f1de85e4b378e71a761a75aaTest
https://doi.org/10.1016/j.antiviral.2019.02.008Test -
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المؤلفون: Inchul You, Brian J. Groendyke, Mingxing Teng, Michael P. Agius, Jinhua Wang, Irene M. Ghobrial, SeongShick Ryu, Yunju Nam, Sara J. Buhrlage, Michelle W. Ma, Xiaoxi Liu, Taebo Sim, Yanke Liang, Dennis Dobrovolsky, Wanyi Hu, Mingfeng Hao, Eric S. Fischer, John M. Hatcher, Katherine A. Donovan, Nathanael S. Gray, Kun Shi, Hong Yue, Li Tan, Jianwei Che, Jonathan W. Bushman, Hanna Cho, Debabrata Bhunia, Sandip Sengupta, Fleur M. Ferguson, Nicholas A. Eleuteri, Zhengnian Li, Theresa D. Manz, Injae Shin, Baishan Jiang
المصدر: Cell
مصطلحات موضوعية: Adult, Male, Proteomics, Proteasome Endopeptidase Complex, Proteome, kinase, Ubiquitin-Protein Ligases, Computational biology, Protein degradation, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, PROTAC, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Resource (project management), Ubiquitin, ubiquitin, Humans, Kinome, RNA, Messenger, IMiD, Databases, Protein, E3 ligase, 030304 developmental biology, 0303 health sciences, biology, targeted degradation, Middle Aged, Small molecule, Ubiquitin ligase, Drug development, Proteasome, degrader, Proteolysis, biology.protein, Female, Protein Kinases, ubiquitin proteasome system, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b88be74fc840eb95fa268c0bb40a267Test
https://pubmed.ncbi.nlm.nih.gov/33275901Test -
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المؤلفون: Thomas W. Gero, John Thomas Feutrill, Bailing Chen, Nathanael S. Gray, Feru Frederic, Brian J. Groendyke, Hilary Szabo, Zhengnian Li, Bin Li, David A. Scott, Chelsea E. Powell
المصدر: Bioorganicmedicinal chemistry letters. 30(19)
مصطلحات موضوعية: Male, Scaffold, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Compound 32, TNK2, Cell Line, Residue (chemistry), chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Stability, Drug Discovery, Animals, Humans, Protein kinase A, Molecular Biology, Protein Kinase Inhibitors, Alanine, Benzodiazepinones, Molecular Structure, 010405 organic chemistry, Chemistry, Effector, Organic Chemistry, Tyrosine phosphorylation, Protein-Tyrosine Kinases, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Pyrimidines, Microsomes, Liver, Molecular Medicine, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220bb5eba35eecf2c507de3c0f2c8533Test
https://pubmed.ncbi.nlm.nih.gov/32739400Test