دورية أكاديمية
In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride.
| العنوان: | In vitro anti-Helicobacter pylori activity and antivirulence activity of cetylpyridinium chloride. |
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| المؤلفون: | Mingjin Xun, Zhong Feng, Hui Li, Meicun Yao, Haibo Wang, Ruixia Wei, Junwei Jia, Zimao Fan, Xiaoyan Shi, Zhanzhu Lv, Guimin Zhang |
| المصدر: | PLoS ONE, Vol 19, Iss 4, p e0300696 (2024) |
| بيانات النشر: | Public Library of Science (PLoS), 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | The primary treatment method for eradicating Helicobacter pylori (H. pylori) infection involves the use of antibiotic-based therapies. Due to the growing antibiotic resistance of H. pylori, there has been a surge of interest in exploring alternative therapies. Cetylpyridinium chloride (CPC) is a water-soluble and nonvolatile quaternary ammonium compound with exceptional broad-spectrum antibacterial properties. To date, there is no documented or described specific antibacterial action of CPC against H. pylori. Therefore, this study aimed to explore the in vitro activity of CPC against H. pylori and its potential antibacterial mechanism. CPC exhibited significant in vitro activity against H. pylori, with MICs ranging from 0.16 to 0.62 μg/mL and MBCs ranging from 0.31 to 1.24 μg/mL. CPC could result in morphological and physiological modifications in H. pylori, leading to the suppression of virulence and adherence genes expression, including flaA, flaB, babB, alpA, alpB, ureE, and ureF, and inhibition of urease activity. CPC has demonstrated in vitro activity against H. pylori by inhibiting its growth, inducing damage to the bacterial structure, reducing virulence and adherence factors expression, and inhibiting urease activity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0300696&type=printableTest; https://doaj.org/toc/1932-6203Test |
| DOI: | 10.1371/journal.pone.0300696&type=printable |
| DOI: | 10.1371/journal.pone.0300696 |
| الوصول الحر: | https://doaj.org/article/3e732b6e2f1343e888ce1ba016a797d6Test |
| رقم الانضمام: | edsdoj.3e732b6e2f1343e888ce1ba016a797d6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0300696&type=printable |