التفاصيل البيبلوغرافية
| العنوان: |
Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study |
| المؤلفون: |
Channon-Wells, S, Vito, O, McArdle, AJ, Seaby, EG, Patel, H, Shah, P, Pazukhina, E, Wilson, C, Broderick, C, D'Souza, G, Keren, I, Nijman, RG, Tremoulet, A, Munblit, D, Ulloa-Gutierrez, R, Carter, MJ, Ramnarayan, P, De, T, Hoggart, C, Whittaker, E, Herberg, JA, Kaforou, M, Cunnington, AJ, Blyuss, O, Levin, M, Chouli, M, Hamadouche, N, Ladj, MS, Agrimbau Vázquez, J, Carmona, R, Collia, AG, Ellis, A, Natta, D, Pérez, L, Rubiños, M, Veliz, N, Yori, S, Britton, PN, Burgner, DP, Carey, E, Crawford, NW, Giuliano, H, McMinn, A, Wong, S, Wood, N, Holter, W, Krainz, M, Ulreich, R, Zurl, C, Dehoorne, J, Haerynck, F, Hoste, L, Schelstraete, P, Vandekerckhove, K, Willems, J, Almeida Farias, CG, Almeida, FJ, Alves Leal, I, Araujo da Silva, AR, Araujo e Silva, AE, Barreiro, STA, Bomfim Prado da Silva, DG, Cervi, MC, Dos Santos Naja Cardoso, MV, Henriques Teixeira, C, Jarovsky, D, Martins Araujo, J, Naaman Berezin, E, Palazzi Sáfadi, MA, Paternina-de la Ossa, RA, Souza Vieira, C, Dimitrova, A, Ganeva, M, Stefanov, S, Telcharova-Mihaylovska, A, Biggs, CM, Lopez, A, Scuccimarri, R, Tan, R, Wasserman, S, Withington, D, Ampuero, C, Aravena, J, Bustos B, R, Casanova, D, Cruces, P, Diaz, F, García-Salum, T, Godoy, L, Medina, RA, Valenzuela Galaz, G, Camacho-Moreno, G, Avila-Aguero, ML, Brenes-Chacón, H, Camacho-Badilla, K, Ivankovich-Escoto, G, Naranjo-Zuniga, G, Soriano-Fallas, A, Yock-Corrales, A, Amer, MA, Abdelmeguid, Y, Ahmed, YHHZ, Badib, A, Badreldin, K, Elkhashab, Y, Heshmat, H, Hussein, A, Mohamed Hussein, AH, Ibrahim, S, Shoman, W, Yakout, RM, Heinonen, S, Angoulvant, F, Belot, A, Ouldali, N, Beske, F, Heep, A, Masjosthusmann, K, Reiter, K, Van den Heuvel, I, Von Both, U, Agrafiotou, A, Antachopoulos, C, Charisi, K, Eleftheriou, I, Farmaki, E, Fotis, L, Kafetzis, D, Koletsi, P, Kourtesi, K, Lampidi, S, Liakopoulou, T, Maritsi, D, Michailidou, E, Milioudi, M, Mparmpounaki, I, Papadimitriou, E, Papaevangelou, V, Roilides, E, Tsiatsiou, O, Tsolas, G, Tsolia, M, Vantsi, P, Banegas Pineda, LY, Borjas Aguilar, KL, Cantillano Quintero, EM, Ip, P, Kwan, MYW, Kwok, J, Lau, YL, To, K, Wong, JSC, David, M, Farkas, D, Kalcakosz, S, Szekeres, K, Zsigmond, B, Aslam, N, Luder, A, Andreozzi, L, Bianco, F, Bucciarelli, V, Buonsenso, D, Cimaz, R, De Luca, M, Dellepiane, RM, Fabi, M, Filice, E, Lanari, M, Lo Vecchio, A, Mastrolia, MV, Mauro, A, Mazza, A, Papa, MV, Romani, L, Scarano, SM, Simonini, G, Tipo, V, Verdoni, L, Macharia, A-M, Musiime, G, Reel, B, Wangai, F, Pace, D, Torpiano, P, Anaya-Enriquez, N, Carreon-Guerrero, JM, Chacon-Cruz, E, Cheung López, M, Faugier Fuentes, E, Fonseca Flores, M, García-Domínguez, M, Giron Vargas, AL, Lopez-Delgado, I, Lopez Hernández, L, Menchaca Aguayo, HF, Montaño-Duron, JG, Pérez-Gaxiola, G, Ramos Tiñini, P, Tostado-Morales, E, Valadez, J, Inchley, C, Klevberg, S, Knudsen, PK, Måseide, PH, Carrera, JM, Castaño, E, Daza Timana, CA, De Leon, T, Estripeaut, D, Levy, J, Norero, X, Record, J, Rojas-Bonilla, M, Wong, M, Iramain, R, Hernandez, R, Huamán, G, Munaico, M, Peralta, C, Seminario, D, Zapata Yarlequé, EH, Gadzinska, J, Ludwikowska, K, Mandziuk, J, Okarska-Napierała, M, Alacheva, ZA, Alexeeva, E, Ananin, PV, Antsupova, M, Bakradze, MD, Berbenyuk, A, Bobkova, P, Borzakova, S, Chashchina, IL, El-Taravi, Y, Fisenko, AP, Gautier, MS, Glazyrina, A, Gorlenko, C, Grosheva, M, Kiselev, H, Kondrikova, E, Korobyants, E, Korsunskiy, AA, Kovygina, K, Krasnaya, E, Kurbanova, S, Kurdup, MK, Mamutova, AV, Mazankova, L, Mitushin, IL, Nargizyan, A, Orlova, YO, Osmanov, IM, Polyakova, AS, Pushkareva, A, Romanova, O, Samitova, E, Shvedova, A, Sologub, A, Iakovleva, E, Tepaev, RF, Tkacheva, AA, Yegiyan, M, Yusupova, V, Zholobova, E, Grasa, CD, Epalza, C, Lopez Segura, N, Martinon-Torres, F, Melendo, S, Mendez-Echevarria, A, Mesa Guzmán, JM, Palacios Argueta, JR, Rivero-Calle, I, Rivière, J, Rodríguez-González, M, Rojo, P, Sanchez Manubens, J, Soler-Palacin, P, Soriano-Arandes, A, Tagarro, A, Villaverde, S, Altman, M, Brodin, P, Horne, A, Palmblad, K, Brotschi, B, Meyer Sauteur, P, Pachlopnik Schmid, J, Prader, S, Relly, C, Schlapbach, LJ, Seiler, M, Strasser, S, Trück, J, Weber, K, Wütz, D, Hamdan, A, Melhem, I, Moussa, A, Dunk, J, Ketharanathan, N, Vermont, C, Akyüz Özkan, E, Cetin, BS, Erdeniz, EH, Şahin, IO, Borisova, G, Boyarchuk, O, Boychenko, L, Boyko, Y, Diudenko, N, Dyvonyak, O, Kasiyan, O, Katerynych, K, Kostyuchenko, L, Mamenko, M, Melnyk, K, Miagka, N, Nazarenko, L, Nezgoda, I, Rykova, S, Svyst, O, Teslenko, M, Trykosh, M, Vasilenko, N, Volokha, A, Adams, C, Akomolafe, T, Al-Abadi, E, Alders, N, Alifieraki, S, Ansumanu, H, Aston, E, Avram, P, Bamford, A, Banks, M, Basu Roy, R, Beattie, T, Boleti, O, Bracken, A, Broad, J, Cai, J, Carrol, ED, Carter, M, Chandran, A, Charlesworth, J, Chawla, J, Cooper, H, Cooray, S, Davies, P, Davis, F, Drysdale, SB, Dzora, E, Emonts, M, Evans, C, Fidler, K, Foster, C, Gong, C, Gongrun, B, Gonzalez, C, Gorgun, B, Grandjean, L, Grant, K, Guo, J, Hacohen, Y, Hall, J, Hamid, HKS, Hassell, J, Hesketh, C, Hewlett, J, Hnieno, A, Holt-Davis, H, Hossain, A, Hu, S, Hudson, LD, Jheeta, S, Johnson, M, Johnson, S, Jyothish, D, Kampmann, B, Kavirayani, A, Kelly, D, Kirubakaran, A, Kucera, F, Langer, D, Lawson, G, Lees, EA, Lenihan, R, Lillie, J, Longbottom, K, Lyall, H, Mackdermott, N, Maltby, S, Mclelland, T, McMahon, A-M, Miller, D, Miranda, M, Mirza, L, Morrison, Z, Moshal, K, Muller, J, Musuka, P, Myttaraki, E, Nadel, S, Nair, S, Nuttall, L, Oremakinde, O, Osaghae, D, Osman, F, Ostrzewska, A, Paccagnella, D, Panthula, M, Papachatzi, E, Papadopoulou, C, Patel, F, Payne, H, Penner, J, Polandi, S, Prendergast, AJ, Ranasinghe, L, Ravichandran, M, Rhys-Evans, S, Riordan, A, Rodrigues, CMC, Roe, L, Romaine, S, Schobi, N, Seddon, J, Shingadia, D, Sikdar, O, Srivastava, A, Struik, S, Sun, T, Tan, RW, Taylor, A, Tran, S, Tsagkaris, S, Tudor-Williams, G, Van den Berg, S, Van der Velden, F, Ventilacion, L, Wellman, PA, Withers Green, J, Yanney, MP, Yeung, S, Badheka, A, Badran, S, Bailey, DM, Burch, AK, Burns, JC, Cichon, C, Cirks, B, Dallman, MD, Delany, DR, Fairchok, M, Friedman, S, Geracht, J, Langs-Barlow, A, Mann, K, Padhye, A, Quade, A, Ramirez, KA, Rockett, J, Sayed, IA, Santos, RP, Shahin, AA, Umaru, S, Widener, R, Mujuru, HA, Kandawasvika, G |
| المصدر: |
e199 ; e184 |
| بيانات النشر: |
Elsevier BV |
| سنة النشر: |
2023 |
| المجموعة: |
Imperial College London: Spiral |
| الوصف: |
Background Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. Methods The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. Findings We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| تدمد: |
2665-9913 |
| العلاقة: |
The Lancet Rheumatology; http://hdl.handle.net/10044/1/103171Test |
| DOI: |
10.1016/s2665-9913(23)00029-2 |
| الإتاحة: |
https://doi.org/10.1016/s2665-9913Test(23)00029-2
http://hdl.handle.net/10044/1/103171Test |
| حقوق: |
Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.ADC92B43 |
| قاعدة البيانات: |
BASE |
