دورية أكاديمية
The effect of whole-body cooling on renal function in post-cardiac arrest patients
| العنوان: | The effect of whole-body cooling on renal function in post-cardiac arrest patients |
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| المؤلفون: | De Rosa, Silvia, De Cal, Massimo, Joannidis, Michael, Villa, Gianluca, Pacheco, Jose Luis Salas, Virzì, Grazia Maria, Samoni, Sara, D'ippoliti, Fiorella, Marcante, Stefano, Visconti, Federico, Lampariello, Antonella, Zannato, Marina, Marafon, Silvio, Bonato, Raffaele, Ronco, Claudio |
| المساهمون: | De Rosa, Silvia, De Cal, Massimo, Joannidis, Michael, Villa, Gianluca, Pacheco, Jose Luis Sala, Virzì, Grazia Maria, Samoni, Sara, D'Ippoliti, Fiorella, Marcante, Stefano, Visconti, Federico, Lampariello, Antonella, Zannato, Marina, Marafon, Silvio, Bonato, Raffaele, Ronco, Claudio |
| سنة النشر: | 2017 |
| المجموعة: | Università degli Studi di Trento: CINECA IRIS |
| مصطلحات موضوعية: | Acute kidney injury, Cardiac arrest, Hypothermia, Ischemia reperfusion injury, Rewarming Injury |
| الوصف: | Background: To evaluate the incidence of Acute Kidney Injury (AKI) during therapeutic hypothermia (TH) and rewarming in comatose patients resuscitated from Cardiac Arrest (CA).Methods: We have performed a pilot study of consecutive comatose patients resuscitated from CA and admitted to our Intensive Care Unit (ICU) from January 2013 to March 2015. The surface cooling devices used were: 1) Arctic Sun (R) 5000; 2) Blanketrol (R) III. Data obtained at baseline and during TH included: temperature trend and rate, serum creatinine, interleukin 1-beta, interleukin 6 (IL-6), urinary Interleukin-18 (uIL-18), diuretic use, urine output, fluid balance (FB). AKI was defined according to Kidney Diseases Improving Global Outcomes (KDIGO) criteria.Results: Thirty-six patients were treated with TH out of 46 ICU admissions (78%). According to KDIGO classification, 21 (58%) had no evidence of AKI while 15 (41.7%) presented AKI during TH. In particular, the incidence of AKI was 2.8% at 24 h, 33.33% at 48 h and 30.6% at 72 h from the onset of cooling. Slower rewarming (above 600 min) was associated with with a non-significant lower incidence of AKI and with a non-significant lower levels of IL-6 and IL-18u. Only two patients required renal replacement therapy during TH (7.6%). Median cumulative FB was 2441 [437-4043] ml for all patients; 3140 [1421-4347] and 1332 [-131-3772] specifically for AKI and not-AKI patients.Conclusions: The hypothermia treatment, if not well performed, could be a double-edged sword for kidneys: whereas hypothermia may confer protection by reducing metabolism and oxygen consumption, rapid rewarming could nullify benefits leading to a worsening of kidney function and AKI. Additional clinical studies are needed to determine the optimal rewarming rate and strategy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/29284424; info:eu-repo/semantics/altIdentifier/wos/WOS:000418927200001; volume:18; issue:1; firstpage:37601; lastpage:37610; numberofpages:10; journal:BMC NEPHROLOGY; https://hdl.handle.net/11572/364365Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85039551887; https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0780-6Test |
| DOI: | 10.1186/s12882-017-0780-6 |
| الإتاحة: | https://doi.org/10.1186/s12882-017-0780-6Test https://hdl.handle.net/11572/364365Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B3EFC916 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12882-017-0780-6 |
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