نتائج البحث - "Yvan Varisco"

المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience
Journal of Neuroscience, vol. 32, no. 28, pp. 9677-9689

مصطلحات موضوعية: Male, Time Factors, Plaque, Amyloid, Hippocampus, p38 Mitogen-Activated Protein Kinases, Rats, Sprague-Dawley, Amyloid beta-Protein Precursor, Mice, 0302 clinical medicine, CX3CR1, Cells, Cultured, Aged, 80 and over, Cerebral Cortex, Neurons, 0303 health sciences, Microscopy, Confocal, Microglia, General Neuroscience, Articles, Middle Aged, 3. Good health, Neuroprotective Agents, medicine.anatomical_structure, Female, Receptors, Chemokine, Protein Binding, medicine.drug, Amyloid, Green Fluorescent Proteins, CX3C Chemokine Receptor 1, Dose-Response Relationship, Immunologic, Enzyme-Linked Immunosorbent Assay, Mice, Transgenic, Biology, Neuroprotection, Statistics, Nonparametric, Proinflammatory cytokine, 03 medical and health sciences, Double-Blind Method, Alzheimer Disease, Presenilin-1, medicine, Animals, Humans, Bapineuzumab, Aged, Alzheimer Disease/blood, Alzheimer Disease/immunology, Amyloid beta-Peptides/immunology, Amyloid beta-Peptides/metabolism, Amyloid beta-Protein Precursor/genetics, Animals, Newborn, Cerebral Cortex/cytology, Disease Models, Animal, Dose-Response Relationship, Drug, Gene Expression Regulation/drug effects, Gene Expression Regulation/genetics, Green Fluorescent Proteins/genetics, Hippocampus/cytology, Immunoglobulin G/metabolism, Immunoglobulin G/pharmacology, Microglia/drug effects, Microglia/metabolism, Mutation/genetics, Neurons/drug effects, Neurons/metabolism, Neuroprotective Agents/metabolism, Neuroprotective Agents/pharmacology, Peptide Fragments/metabolism, Plaque, Amyloid/immunology, Plaque, Amyloid/metabolism, Presenilin-1/genetics, Protein Binding/drug effects, Rats, Receptors, Chemokine/genetics, Tumor Necrosis Factor-alpha/metabolism, p38 Mitogen-Activated Protein Kinases/metabolism, 030304 developmental biology, Amyloid beta-Peptides, Tumor Necrosis Factor-alpha, Peptide Fragments, Gene Expression Regulation, Immunoglobulin G, Mutation, Crenezumab, Immunology, Cancer research, Gantenerumab, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cbe1eb7083c2049180d072e90c4036Test

8

P4–316: Visualization of beta‐amyloid plaque reduction by small‐molecule beta‐amyloid oligomer aggregation inhibitors in hAPPSL transgenic mice

المؤلفون: Nampally Sreenivasachary, Yvan Varisco, Pascal Benderitter, Andreas Muhs, Anne Hamel, Andrea Pfeifer, Heiko Kroth, Wolfgang Froestl, Paolo Paganetti

المصدر: Alzheimer's & Dementia. 9

مصطلحات موضوعية: Genetically modified mouse, Amyloid, Epidemiology, Chemistry, Health Policy, Oligomer, Small molecule, Molecular biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, Neurology (clinical), Geriatrics and Gerontology, Beta (finance)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::89f93e3857a0262069792624ade22470Test
https://doi.org/10.1016/j.jalz.2013.08.268Test

9

Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation

المصدر: Journal of Biological Chemistry
The journal of biological chemistry 287(41), 34786-34800 (2012). doi:10.1074/jbc.M112.357665
Kroth, H, Ansaloni, A, Varisco, Y, Jan, A, Sreenivasachary, N, Rezaei-Ghaleh, N, Giriens, V, Lohmann, S, López-Deber, M P, Adolfsson, O, Pihlgren, M, Paganetti, P, Froestl, W, Nagel-Steger, L, Willbold, D, Schrader, T, Zweckstetter, M, Pfeifer, A, Lashuel, H A & Muhs, A 2012, ' Discovery and structure activity relationship of small molecule inhibitors of toxic β-amyloid-42 fibril formation ', The Journal of biological chemistry, vol. 287, no. 41, pp. 34786-800 . https://doi.org/10.1074/jbc.M112.357665Test

مصطلحات موضوعية: 3-aminopyrazole, antagonists & inhibitors [Amyloid beta-Peptides], antagonists & inhibitors [Cytotoxins], antagonists & inhibitors [Peptide Fragments], Chemie, chemistry [Cytotoxins], Protein aggregation, Biochemistry, Protein Structure, Secondary, Hydrophobic effect, Structure-Activity Relationship, Protein structure, Cell Line, Tumor, mental disorders, Journal Article, Humans, Structure–activity relationship, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Cytotoxins, Chemistry, Research Support, Non-U.S. Gov't, In vitro toxicology, Molecular Bases of Disease, Hydrogen Bonding, Cell Biology, amyloid beta-protein (1-42), Small molecule, Peptide Fragments, Amino acid, chemistry [Peptide Fragments], ddc:540, chemistry [Pyrazoles], Pyrazoles, chemistry [Amyloid beta-Peptides], Hydrophobic and Hydrophilic Interactions, Linker

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f1d6b8bb6eb1e9cd8d68fd89416ac0Test
https://hdl.handle.net/11858/00-001M-0000-000E-7305-311858/00-001M-0000-000E-7304-511858/00-001M-0000-000E-7300-DTest

10

P1‐338: Comparison of toxic beta‐amyloid oligomer inhibitors for rescuing memory deficits in APP transgenic mice

المؤلفون: Nampally Sreenivasachary, Andrea Pfeifer, Yvan Varisco, Andreas Muhs, Cotinica Hame, Paolo Paganetti, Rime Madani, Pascal Benderitter, Heiko Kroth, Adeline Plassard, Wolfgang Froestl, Wolfgang Barth

المصدر: Alzheimer's & Dementia. 8

مصطلحات موضوعية: Genetically modified mouse, Amyloid, Epidemiology, Health Policy, Oligomer, Molecular biology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, chemistry, Neurology (clinical), Geriatrics and Gerontology, Beta (finance)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fec4be97fe9749b6d97dd56decb921f2Test
https://doi.org/10.1016/j.jalz.2012.05.2024Test

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