دورية أكاديمية
THE EFFECT OF AUTOMESOCONCENTRATE OF PLATELETS ON THE STAGES OF REGENERATION OF THE LIVER REMNANT OF RATS UNDER THE CONDITIONS OF PERFORMING VOLUMETRIC EXPERIMENTAL LIVER RESECTIONS ; ВПЛИВ АУТОМЕЗОКОНЦЕНТРАТУ ТРОМБОЦИТІВ НА ЕТАПИ РЕГЕНЕРАЦІЇ ПЕЧІНКОВОГО ЗАЛИШКУ ЩУРІВ ЗА УМОВ ВИКОНАННЯ ОБ’ЄМНИХ ЕКСПЕРИМЕНТАЛЬНИХ РЕЗЕКЦІЙ ПЕЧІНКИ
| العنوان: | THE EFFECT OF AUTOMESOCONCENTRATE OF PLATELETS ON THE STAGES OF REGENERATION OF THE LIVER REMNANT OF RATS UNDER THE CONDITIONS OF PERFORMING VOLUMETRIC EXPERIMENTAL LIVER RESECTIONS ; ВПЛИВ АУТОМЕЗОКОНЦЕНТРАТУ ТРОМБОЦИТІВ НА ЕТАПИ РЕГЕНЕРАЦІЇ ПЕЧІНКОВОГО ЗАЛИШКУ ЩУРІВ ЗА УМОВ ВИКОНАННЯ ОБ’ЄМНИХ ЕКСПЕРИМЕНТАЛЬНИХ РЕЗЕКЦІЙ ПЕЧІНКИ |
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| المؤلفون: | Salyutin, Ruslan V., Yuzvyk, Kostyantyn O. |
| المصدر: | Clinical and Preventive Medicine; No 2 (2024): Clinical and Preventive Medicine; 35-42 ; Клиническая и профилактическая медицина; № 2 (2024): Clinical and Preventive Medicine; 35-42 ; Клінічна та профілактична медицина; № 2 (2024): Клінічна та профілактична медицина; 35-42 ; 2616-4868 |
| بيانات النشر: | Scientific and Practical Center of Preventive and Clinical Medicine |
| سنة النشر: | 2024 |
| المجموعة: | Clinical and Preventive Medicine (E-Journal) / Клінічна та профілактична медицина |
| مصطلحات موضوعية: | liver resection, regeneration, growth factors, interleukins, automesoconcentrate of platelets, резекція печінки, регенерація, фактори росту, інтерлейкіни, аутомезоконцентрат тромбоцитів |
| الوصف: | Introduction. Liver regeneration occurs in three stages, each of which is regulated by different factors: the initiation phase is regulated by interleukin 6 (IL-6) and tumor necrosis factor (TNFα); expansion phase – by hepatocyte growth factor (HGF) and transforming growth factor alpha (TGFα); the terminal phase – transforming growth factor beta (TGFβ) and activins. The work determined the level of markers of the main stages of liver regeneration after resection of 65-70% of the parenchyma of this organ in rats under the conditions of using different doses and schemes of administration of automesoconcentrate of platelets (AMС). The purpose of the study is to establish the characteristics of changes in the level of cytokines and growth factors in the homogenate of the liver of rats after resection of 65-70% of the parenchyma of this organ under the conditions of the use of different doses and schemes of AMС administration. Materials and methods. The study was conducted on white Wistar rats aged 1.5-2 months, weighing 150-180 g. AMС was injected: into the parenchyma of the liver remnant during resection at a dose of 0.5 ml/kg (group I); into the tail vein in the postoperative period at a dose of 0.5 ml/kg 3 hours and 48 hours after liver resection (group II); into the tail vein in the postoperative period at a dose of 1.0 ml/kg 3 hours and 48 hours after resection. Research results and discussion. It was shown that on the 7th day after liver resection, the level of TNF-α and IL-6 increased in all experimental groups, followed by a decrease on the 10th day to control values in the group of animals that received AMA intravenously at a dose of 1 ml/kg masses of animals. It was established that the values of HGF and TGFα in the liver homogenate of animals that underwent liver resection were significantly higher than in the control group on the 7th day of the experiment. At the later stages of the experiment, a decrease in the levels of HGF and TGFα in the liver homogenate was observed in the animals of groups I and ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Ukrainian |
| العلاقة: | http://cp-medical.com/index.php/journal/article/view/387/350Test; http://cp-medical.com/index.php/journal/article/view/387Test |
| DOI: | 10.31612/2616-4868.2.2024.05 |
| الإتاحة: | https://doi.org/10.31612/2616-4868.2.2024.05Test http://cp-medical.com/index.php/journal/article/view/387Test |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test |
| رقم الانضمام: | edsbas.E6AC47E9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.31612/2616-4868.2.2024.05 |
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