دورية أكاديمية
Standard-Intensity Versus Low-Intensity Anticoagulation with Warfarin in Asian Patients with Atrial Fibrillation: A Multi-Center, Randomized Controlled Trial
| العنوان: | Standard-Intensity Versus Low-Intensity Anticoagulation with Warfarin in Asian Patients with Atrial Fibrillation: A Multi-Center, Randomized Controlled Trial |
|---|---|
| المؤلفون: | Jeong Gwan Cho MD, PhD, Ki Hong Lee MD, PhD, Yoo Ri Kim MD, PhD, Sunah Kim RN, CRC, CRA, Jisoo Gwak RN, CRC, CRA, Eunbit Cho MLS, CRC, CRA, Yourim Sin RN, CRC, CRA, Seung Yong Shin MD, PhD, Hyung Wook Park MD, PhD, Jum Suk Ko MD, PhD, Nam Ho Kim MD, PhD, Yae Min Park MD, PhD, Jung Myung Lee MD, PhD, Nam Sik Yoon MD, PhD, Sung Soo Kim MD, PhD, Jun Hyung Kim MD, PhD, Dong Min Kim MD, PhD |
| المصدر: | Clinical and Applied Thrombosis/Hemostasis, Vol 29 (2023) |
| بيانات النشر: | SAGE Publishing, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: | Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: | Anticoagulation with warfarin in Asian patients with atrial fibrillation (AF) often has been decreased as an international normalized ratio (INR) of prothrombin time 1.6-2.6 due to fear of bleeding, although universal criteria recommend an INR of 2.0-3.0. In this randomized, open-label trial, low-intensity anticoagulation (INR 1.6-2.6) was compared with standard-intensity anticoagulation (INR 2.0-3.0) with warfarin. A total 616 patients with AF and at least 1 risk factor for stroke were randomized to low-intensity anticoagulation (n = 308) and standard-intensity anticoagulation (n = 308) groups. The intention-to-treat analysis was performed to determine differences. The baseline characteristics of the two groups were comparable. New-onset stroke occurred in 2 patients (0.44% per year) in the low-intensity group and 5 patients (1.05% per year) in the standard-intensity group (HR 0.42, 95% CI 0.08-2.15). Major bleeding occurred in 4 patients (0.89% per year) in the low-intensity group and 5 patients (1.06% per year) in the standard-intensity group (HR 0.84, 95% CI 0.22-3.11). The rate of the net clinical outcome (composite of stroke, systemic embolism, major bleeding, and death) was 1.33% per year in the low-intensity group compared with 2.12% per year in the standard-intensity group (HR 0.63, 95% CI 0.23-1.72). In Asian patients with AF, clinical outcomes were not different between low-intensity and standard-intensity anticoagulation with warfarin. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1938-2723 10760296 |
| العلاقة: | https://doaj.org/toc/1938-2723Test |
| DOI: | 10.1177/10760296231171081 |
| الوصول الحر: | https://doaj.org/article/e9a27eb9005844d282d14ef4be786989Test |
| رقم الانضمام: | edsdoj.9a27eb9005844d282d14ef4be786989 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19382723 10760296 |
|---|---|
| DOI: | 10.1177/10760296231171081 |