دورية أكاديمية
Sex and Gender Differences in Neurodegenerative Diseases: Challenges for Therapeutic Opportunities
| العنوان: | Sex and Gender Differences in Neurodegenerative Diseases: Challenges for Therapeutic Opportunities |
|---|---|
| المؤلفون: | Annalisa Bianco, Ylenia Antonacci, Maria Liguori |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 7, p 6354 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | neurodegenerative diseases, autoimmunity, sex/gender differences, disease heterogeneity, multiple sclerosis, Parkinson’s disease, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The term “neurodegenerative diseases” (NDs) identifies a group of heterogeneous diseases characterized by progressive loss of selectively vulnerable populations of neurons, which progressively deteriorates over time, leading to neuronal dysfunction. Protein aggregation and neuronal loss have been considered the most characteristic hallmarks of NDs, but growing evidence confirms that significant dysregulation of innate immune pathways plays a crucial role as well. NDs vary from multiple sclerosis, in which the autoimmune inflammatory component is predominant, to more “classical” NDs, such as Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, and spinal muscular atrophy. Of interest, many of the clinical differences reported in NDs seem to be closely linked to sex, which may be justified by the significant changes in immune mechanisms between affected females and males. In this review, we examined some of the most studied NDs by looking at their pathogenic and phenotypical features to highlight sex-related discrepancies, if any, with particular interest in the individuals’ responses to treatment. We believe that pointing out these differences in clinical practice may help achieve more successful precision and personalized care. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/24/7/6354Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms24076354 |
| الوصول الحر: | https://doaj.org/article/c1a6ec392b28493ca9391030a0c9bb69Test |
| رقم الانضمام: | edsdoj.1a6ec392b28493ca9391030a0c9bb69 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
|---|---|
| DOI: | 10.3390/ijms24076354 |