نتائج البحث

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Cen, Y, Singh, W, Arkin, M, Moody, T S, Huang, M, Zhou, J, Wu, Q & Reetz, M T 2019, ' Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution ', Nature Communications, vol. 10, 3198 . https://doi.org/10.1038/s41467-019-11155-3Test

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Stereochemistry, Protein Conformation, Science, Protein design, General Physics and Astronomy, 02 engineering and technology, Crystallography, X-Ray, Protein Engineering, General Biochemistry, Genetics and Molecular Biology, Catalysis, Article, Substrate Specificity, Fungal Proteins, 03 medical and health sciences, Enzyme activator, Catalytic Domain, Hydrolase, Catalytic triad, Cysteine, Lipase, lcsh:Science, Candida, chemistry.chemical_classification, Multidisciplinary, Binding Sites, biology, Hydrolysis, General Chemistry, 021001 nanoscience & nanotechnology, Directed evolution, biology.organism_classification, C700, Enzyme Activation, Kinetics, 030104 developmental biology, Enzyme, chemistry, Mutation, Enzyme mechanisms, biology.protein, Biocatalysis, lcsh:Q, Candida antarctica, 0210 nano-technology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2bb96f00aa229bf6570d77d01eedabTest
https://nrl.northumbria.ac.uk/id/eprint/43298/1/s41467-019-11155-3.pdfTest

7

Customizing the Enantioselectivity of a Cyclohexanone Monooxygenase by a Strategy Combining 'Size-probes' with in silico Study

المؤلفون: Yujing Hu, Yu Zhang, Qi Wu, Jian Xu, Danyang Li, Meilan Huang, Yixin Cen, Xianfu Lin

المصدر: Hu, Y, Xu, J, Cen, Y, Li, D, Zhang, Y, Huang, M, Lin, X & Wu, Q 2019, ' Customizing the Enantioselectivity of a Cyclohexanone Monooxygenase by a Strategy Combining “Size-probes” with in silico Study ', CHEMCATCHEM, vol. 11, no. 20, pp. 5085-5092 . https://doi.org/10.1002/cctc.201901200Test

مصطلحات موضوعية: Inorganic Chemistry, biology, Biotransformation, Chemistry, In silico, Cyclohexanone monooxygenase, Organic Chemistry, biology.protein, Physical and Theoretical Chemistry, Directed evolution, Combinatorial chemistry, Catalysis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbf3c7279b9c1d3f030dea2fec44624Test
https://pure.qub.ac.uk/en/publications/32e7c713-735b-4e69-976d-3308002cf762Test

8

Stereoselectivity-Tailored, Metal-Free Hydrolytic Dynamic Kinetic Resolution of Morita–Baylis–Hillman Acetates Using an Engineered Lipase–Organic Base Cocatalyst

المؤلفون: Zhiwei Xiang, Yixin Cen, Qi Wu, Yujing Hu, Xianfu Lin, Bo Xia, Jian Xu

المصدر: ACS Catalysis. 7:4542-4549

مصطلحات موضوعية: biology, Organic base, 010405 organic chemistry, General Chemistry, 010402 general chemistry, biology.organism_classification, 01 natural sciences, Catalysis, 0104 chemical sciences, Kinetic resolution, chemistry.chemical_compound, chemistry, biology.protein, Organic chemistry, Candida antarctica, Stereoselectivity, Lipase, Racemization, Triethylamine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::bdcf16843e571f0f08386986b09eeacdTest
https://doi.org/10.1021/acscatal.7b01400Test

9

Antitumor gemcitabine conjugated micelles from amphiphilic comb-like random copolymers

المؤلفون: Xiaomin Zhang, Qi Wu, Yixin Cen, Jianfeng Wang, Xianfu Lin

المصدر: Colloids and Surfaces B: Biointerfaces. 146:707-715

مصطلحات موضوعية: Male, Antimetabolites, Antineoplastic, Lung Neoplasms, Polymers, medicine.drug_class, Mice, Nude, Apoptosis, 02 engineering and technology, Conjugated system, Pharmacology, 010402 general chemistry, Deoxycytidine, 01 natural sciences, Antimetabolite, Micelle, Polyethylene Glycols, Rats, Sprague-Dawley, Mice, Drug Delivery Systems, Colloid and Surface Chemistry, PEG ratio, Amphiphile, Tumor Cells, Cultured, medicine, Animals, Humans, Physical and Theoretical Chemistry, Micelles, Cell Proliferation, A549 cell, Drug Carriers, Mice, Inbred BALB C, Chemistry, Surfaces and Interfaces, General Medicine, 021001 nanoscience & nanotechnology, Xenograft Model Antitumor Assays, Gemcitabine, 0104 chemical sciences, Cancer research, 0210 nano-technology, Biotechnology, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f33fc384e64eb75df98663594bd228aTest
https://doi.org/10.1016/j.colsurfb.2016.07.027Test

10

Stereodivergent Protein Engineering of a Lipase to Access All Possible Stereoisomers of Chiral Esters with Two Stereo-centers

المؤلفون: Jian Xu, Jiahai Zhou, Meilan Huang, Lian Wu, Xianfu Lin, Manfred T. Reetz, Jiajie Fan, Warispreet Singh, Yixin Cen, Qi Wu

المصدر: Wu, J, Cen, Y, Singh, W, Fan, J, Wu, L, Lin, X, Zhou, J, Huang, M, Reetz, M & Wu, Q 2019, ' Stereodivergent Protein Engineering of a Lipase to Access All Possible Stereoisomers of Chiral Esters with Two Stereo-centers ', Journal of the American Chemical Society, vol. 141, no. 19, pp. 7934-7945 . https://doi.org/10.1021/jacs.9b02709Test

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02350969176d5f9e56aaf0f2110a80c1Test
https://pure.qub.ac.uk/en/publications/142d8f89-b959-4399-be74-424c2ab6e882Test

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