التفاصيل البيبلوغرافية
| العنوان: |
Metadata record for the article: Tetrathiomolybdate (TM)-associated copper depletion influences collagen remodeling and immune response in the pre-metastatic niche of breast cancer |
| المؤلفون: |
Ying L. Liu (11020161), Cecilie Liv Bager (11020163), Nicholas Willumsen (5040185), Divya Ramchandani (11020164), Naomi Kornhauser (7540631), Lu Ling (11020167), Marta Cobham (11020170), Eleni Andreopoulou (6597213), Tessa Cigler (3852757), Anne Moore (10429753), Dayle LaPolla (11020173), Veronica Fitzpatrick (11020176), Maureen Ward (11020179), J David Warren (11020181), Claudia Fischbach (367682), Vivek Mittal (37386), Linda T. Vahdat (9573921) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Cancer, Biomarkers, Medical and Health Sciences not elsewhere classified, Biological Sciences not elsewhere classified, metastasis, cancer microenvironment, breast cancer, prognostic markers, drug discovery, copper, collagen remodeling, extracellular matrix, premetastatic niche, immune response |
| الوصف: |
Summary This metadata record provides details of the data supporting the claims of the related article: “Tetrathiomolybdate (TM)-associated copper depletion influences collagen remodeling and immune response in the pre-metastatic niche of breast cancer”. The related study sought to elucidate the mechanism of tetrathiomolybdate (TM) by exploring its effects on collagen processing and immune function in the tumour microenvironment (TME). Type of data: flow cytometry; clinical data Subject of data: Homo sapiens; Mouse syngeneic TNBC cell lines EO771 (obtained from Robin Anderson lab, La Trobe University, Australia) and its lung metastatic derivative EO771.ML1 (derived according to standard protocol at Mittal lab, WCM) Sample size: 75 Population characteristics: >=18 years of age; histologically confirmed stage II TNBC, stage III, or stage IV with no evidence of disease of all molecular subtypes; no radiographic, biochemical, or physical evidence of active breast cancer; more than 6 weeks from previous therapy including surgery, radiation, chemotherapy, biologic treatment; Eastern Cooperative Oncology Group performance status 0–1 and adequate organ function. Trial registration number: NCT00195091 Data access The data underlying the claims of the related article are contained in the following files: - STATA file ‘TM_Survival_Stage_12-1-2020.dta’ - STATA file ‘TM_Collagen_CPdata_Wide_1-6-2021.dta’ - GraphPad file ‘LungBLI-Flow-IF 08-21-2020.pzfx’ - GraphPad file ‘LungSampleAnalysis 09-24-2018.pzfx’ (also available in .xlsx format) - Excel file ‘TM Demographics all 75 pts.xlsx’ - Excel file ‘AEs all pts 6-2018.xlsx’ - GraphPad file ‘LungFlow 04-28-2020.pzfx’ Authors have chosen not to share the data publicly as they contain ongoing, unpublished work included in other projects. However, the data are available upon request from the corresponding author. Corresponding author(s) for this study Linda T. Vahdat MD MBA. Chief, Cancer Services Memorial Sloan Kettering Physicians at Norwalk Hospital; Member, Breast Medicine ... |
| نوع الوثيقة: |
text |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/online_resource/Metadata_record_for_the_article_Tetrathiomolybdate_TM_-associated_copper_depletion_influences_collagen_remodeling_and_immune_response_in_the_pre-metastatic_niche_of_breast_cancer/14838309Test |
| DOI: |
10.6084/m9.figshare.14838309.v1 |
| الإتاحة: |
https://doi.org/10.6084/m9.figshare.14838309.v1Test |
| حقوق: |
CC0 |
| رقم الانضمام: |
edsbas.4D8270FA |
| قاعدة البيانات: |
BASE |
