التفاصيل البيبلوغرافية
| العنوان: |
Nematode Signaling Molecules Are Extensively Metabolized by Animals, Plants, and Microorganisms |
| المؤلفون: |
Yan Yu (56143), Ying K. Zhang (4029584), Murli Manohar (423568), Alexander B. Artyukhin (2300026), Anshu Kumari (10843156), Francisco J. Tenjo-Castano (10843159), Hung Nguyen (792999), Pratyush Routray (10843162), Andrea Choe (10843165), Daniel F. Klessig (8924723), Frank C. Schroeder (159898) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Ecology, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, ascaroside stereoisomers, acid side chains, mass spectrometry-based, pheromone editing, nematodes secrete, interspecific interactions, ascaroside biosynthesis, Nematode Signaling Molecules, Extensively Metabolized |
| الوصف: |
Many bacterivorous and parasitic nematodes secrete signaling molecules called ascarosides that play a central role regulating their behavior and development. Combining stable-isotope labeling and mass spectrometry-based comparative metabolomics, here we show that ascarosides are taken up from the environment and metabolized by a wide range of phyla, including plants, fungi, bacteria, and mammals, as well as nematodes. In most tested eukaryotes and some bacteria, ascarosides are metabolized into derivatives with shortened fatty acid side chains, analogous to ascaroside biosynthesis in nematodes. In plants and C. elegans , labeled ascarosides were additionally integrated into larger, modular metabolites, and use of different ascaroside stereoisomers revealed the stereospecificity of their biosynthesis. The finding that nematodes extensively metabolize ascarosides taken up from the environment suggests that pheromone editing may play a role in conspecific and interspecific interactions. Moreover, our results indicate that plants, animals, and microorganisms may interact with associated nematodes via manipulation of ascaroside signaling. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Nematode_Signaling_Molecules_Are_Extensively_Metabolized_by_Animals_Plants_and_Microorganisms/14639485Test |
| DOI: |
10.1021/acschembio.1c00217.s001 |
| الإتاحة: |
https://doi.org/10.1021/acschembio.1c00217.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.B14A649 |
| قاعدة البيانات: |
BASE |
