'Learning' Can Improve the Blood Glucose Control Performance for Type 1 Diabetes Mellitus
| العنوان: | 'Learning' Can Improve the Blood Glucose Control Performance for Type 1 Diabetes Mellitus |
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| المؤلفون: | ChenXiaoping, WangYouqing, ZhangJinping, ZengFanmao, YangWenying, ZhangBo, CobelliClaudio, WangNa, ZhaoDong |
| المصدر: | Diabetes Technology & Therapeutics. 19:41-48 |
| بيانات النشر: | Mary Ann Liebert Inc, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Pancreas, Artificial, 0209 industrial biotechnology, medicine.medical_specialty, Adolescent, Glucose control, Endocrinology, Diabetes and Metabolism, Pilot Projects, 030209 endocrinology & metabolism, 02 engineering and technology, Hypoglycemia, Artificial pancreas, Clinical study, Young Adult, 03 medical and health sciences, Insulin infusion, Insulin Infusion Systems, 020901 industrial engineering & automation, 0302 clinical medicine, Endocrinology, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Feedback, Physiological, Type 1 diabetes, business.industry, Mean age, Middle Aged, medicine.disease, Surgery, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Female, business, Algorithms |
| الوصف: | A learning-type artificial pancreas has been proposed to exploit the repetitive nature in the blood glucose dynamics. We clinically evaluated the efficacy of the learning-type artificial pancreas.We conducted a pilot clinical study in 10 participants of mean age 36.1 years (standard deviation [SD] 12.7; range 16-58) with type 1 diabetes. Each trial was conducted for eight consecutive mornings. The first two mornings were open-loop to obtain the individualized parameters. Then, the following six mornings were closed-loop, during which a learning-type model predictive control algorithm was employed to calculate the insulin infusion rate. To evaluate the algorithm's robustness, each participant took exercise or consumed alcohol on the fourth or sixth closed-loop day and the order was determined randomly. The primary outcome was the percentage of time spent in the target glucose range of 3.9-8.0 mmol/L between 0900 and 1200 h.The percentage of time with glucose spent in target range was significantly improved from 51.6% on day 1 to 71.6% on day 3 (mean difference between groups 17.9%, confidence interval [95% CI] 3.6-32.1; P = 0.020). There were no hypoglycemic episodes developed on day 3 compared with two episodes on day 1. There was no difference in the percentage of time with glucose spent in target range between exercise day versus day 5 and alcohol day versus day 5.The learning-type artificial pancreas system achieved good glycemic regulation and provided increased effectiveness over time. It showed a satisfactory performance even when the blood glucose was challenged by exercise or alcohol. |
| تدمد: | 1557-8593 1520-9156 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::012639171d3b8a94abdab6654dcdee92Test https://doi.org/10.1089/dia.2016.0328Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....012639171d3b8a94abdab6654dcdee92 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578593 15209156 |
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