دورية أكاديمية
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
| العنوان: | Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease |
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| المؤلفون: | Nalls, M.A. (Michael), Pankratz, V.S. (Shane), Lill, C.M. (Christina), Do, C.B. (Chuong), Hernandez, D.G. (Dena), Saad, M. (Mohamad), DeStefano, A.L. (Anita), Kara, E. (Eleanna), Bras, J. (Jose), Sharma, M., Schulte, C. (Claudia), Keller, M.F. (Margaux), Arepalli, S. (Sampath), Letson, C. (Christopher), Edsall, C. (Connor), Kallela, M. (Mikko), Liu, X. (Xinmin), Pliner, H. (Hannah), Lee, J.H. (Joseph H.), Cheng, R. (Rong), Ikram, M.A. (Arfan), Ioannidis, J.P.A. (John), Hadjigeorgiou, G.M. (Georgios M.), Bis, J.C. (Joshua), Martinez, M. (Maria), Perlmutter, J.S. (Joel), Goate, A.M. (Alison M.), Marder, K.S. (Karen S.), Fiske, B. (Brian), Sutherland, M. (Margaret), Xiromerisiou, G. (Georgia), Myers, R.H. (Richard), Clark, L.N. (Lorraine N.), Zwart, J-A. (John-Anker), Hardy, J. (John), Heutink, P. (Peter), Chen, H. (Honglei), Wood, N.W. (Nicholas), Houlden, H. (Henry), Payami, H. (Haydeh), Brice, A., Scott, W.K. (William), Gasser, T. (Thomas), Bertram, L. (Lars), Eriksson, N. (Nicholas), Foroud, T. (Tatiana), Singleton, A. (Andrew) |
| المصدر: | Nature Genetics vol. 46 no. 9, pp. 989-993 |
| سنة النشر: | 2014 |
| المجموعة: | RePub - Publications from Erasmus University, Rotterdam |
| الوصف: | We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In tot |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://repub.eur.nl/pub/90708Test; urn:hdl:1765/90708 |
| DOI: | 10.1038/ng.3043 |
| الإتاحة: | https://doi.org/10.1038/ng.3043Test http://repub.eur.nl/pub/90708Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3769B15D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ng.3043 |
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