نتائج البحث - "Xbp1, X-box binding protein 1"

1

Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion Injury

المؤلفون: Kaatje Lenaerts, Joep Grootjans, Anna M. Kip, Marco Manca, Steven W.M. Olde Damink, Bas Boonen, Cornelis H. C. Dejong, Wim A. Buurman, M'hamed Hadfoune, Joep P. M. Derikx, Erik A.L. Biessen

المساهمون: Gastroenterology and Hepatology, Tytgat Institute for Liver and Intestinal Research, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Surgery, ARD - Amsterdam Reproduction and Development, RS: NUTRIM - R2 - Liver and digestive health, Surgery, Pathologie, RS: Carim - B07 The vulnerable plaque: makers and markers, MUMC+: MA Heelkunde (9)

المصدر: CMGH, 13(3), 681-694. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology : CMGH 13(3), 681-694 (2022). doi:10.1016/j.jcmgh.2021.11.001
Cellular and molecular gastroenterology and hepatology, 13(3), 681-694. Elsevier Inc.
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: ATF4, activating transcription factor 4, CELL-SURVIVAL, eIF2α, eukaryotic translation initiation factor 2A, INDUCED INFLAMMATION, mEGF, mouse epidermal growth factor, EM, Electron microscopy, ROCK, Rho kinase, Intestinal Ischemia-Reperfusion, GADD34, growth arrest and DNA-damage-inducible protein, Transcriptome, ACTIVATION, UPR, unfolded protein response, ENDOPLASMIC-RETICULUM STRESS, Gene expression, I, ischemia, Original Research, Human Intestinal Organoids, Gastroenterology, DEATH, CHOP, CCAAT/enhancer-binding protein homologous protein, BiP, binding immunoglobulin protein, Endoplasmic Reticulum Stress, Cell biology, medicine.anatomical_structure, XBP1, X-box binding protein 1, Reperfusion Injury, JNK, c-Jun N-terminal kinase, qPCR, quantitative polymerase chain reaction, R, reperfusion, HYPOXIA-INDUCIBLE FACTOR, FACTOR-I, NF-κB, nuclear factor-κB, IRE1, inositol-requiring enzyme 1, KAPPA-B, Biology, KEGG, Kyoto Encyclopedia of Genes and Genomes, ER, endoplasmic reticulum, Organoid, medicine, KINASE, Integrated stress response, Humans, C, control, Transcriptomics, GO, gene ontology, Hepatology, Microarray analysis techniques, XBP1s, spliced X-box binding protein 1, Endoplasmic reticulum, PERK, protein kinase R-like ER kinase, Activating Transcription Factor 4, Small intestine, ISRIB, integrated stress response inhibitor, ER, Unfolded protein response, Unfolded Protein Response, HIF1A, hypoxia-inducible factor 1-α, Transcription Factor CHOP, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ba4ffc78867321b72f85db21a76d04Test
http://www.scopus.com/inward/record.url?scp=85121206348&partnerID=8YFLogxKTest

2

A small molecule UPR modulator for diabetes identified by high throughput screening

المؤلفون: Siying Zhu, Matthew S. Tremblay, Sean B. Joseph, Seung Hyuk Choi, Mitch Hull, Weijun Shen, Valeria Marrocco, Sijia Li, Marta Diez Cunado, Ana M. Gamo, Tuan Tran, Jason Roland, Arnab K. Chatterjee, Qiangwei Fu, Van Nguyen-Tran, Nikki Rogers

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)

مصطلحات موضوعية: TG, thapsigargin, Cell signaling, ATF4, activating transcription factor 4, IKKβ, inhibitor of nuclear factor kappa-B kinase subunit beta, PERK, PKR-like ER kinase, XBP1, X-box-binding protein 1, OGTT, oral glucose tolerance test, GAPDH, glyceraldehyde 3-phosphate dehydrogenase, Unfolded protein response, 0302 clinical medicine, UPR, unfolded protein response, GLuc, Gaussia luciferase, Chaperones, Protein biosynthesis, IL1β, interleukin 1β, General Pharmacology, Toxicology and Pharmaceutics, uHTS, ultra-high throughput screening, IRE1, inositol requiring enzyme 1α/β, 0303 health sciences, ASGR, asialoglycoprotein receptor 1, biology, Chemistry, Small molecules, Diabetes, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, ATF6, activating transcription factor 6α/β, β cells, i.p., intraperitoneal, Cell biology, Liver, 030220 oncology & carcinogenesis, T1/2D, type1/2 diabetes, Tm, tunicamycin, Protein folding, Original Article, ER stress, NASH, nonalcoholic steatohepatitis, INFγ, interferon gamma, TNFα, tumor necrosis factor alpha, RM1-950, GRPRP94, glucose-regulated protein 94, ER, endoplasmic reticulum, 03 medical and health sciences, SP1/2, serine protease1/2, GRP78, 78-kDa glucose-regulated protein, BID, twice a day, Pancreas, 030304 developmental biology, Reporter gene, Nod, non-obese diabetic, Activator (genetics), Endoplasmic reticulum, Metabolic diseases, Chaperone (protein), EGFP-VSVG, enhanced green fluorescence protein-vesicular stomatitis virus ts045 G protein, GSIS, glucose stimulated insulin secretion, biology.protein, Asialoglycoprotein receptor, Therapeutics. Pharmacology, CLuc, Cypridina luciferase, ERP72, endoplasmic reticulum proteins 72

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c176a631b2a5bf8251732009aad27d09Test
http://europepmc.org/articles/PMC8727761Test

3

Phosphorylation regulates cullin-based ubiquitination in tumorigenesis

المؤلفون: Meidan Ying, Xuejing Shao, Hong Zhu, Ji Cao, Bo Yang, Yifan Chen, Qiaojun He

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 309-321 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: SRC-3, nuclear receptor coactivator 3, VHL, von Hippel-Lindau tumor suppressor, RRM2, ribonucleotide reductase regulatory subunit M2, KRAS, KRAS proto-oncogene, GTPase, SNAIL1, snail family transcriptional repressor 1, medicine.medical_treatment, CRL, cullin-RING ligase, ERK, mitogen-activated protein kinase 1, NEDD8, NEDD8 ubiquitin like modifier, Review, medicine.disease_cause, JAB1, c-Jun activation domain binding protein-1, p130Cas, BCAR1 scaffold protein, Cas family member, law.invention, Targeted therapy, Degradation, 0302 clinical medicine, Ubiquitin, law, RA, retinoic acid, FBXL3, F-box and leucine rich repeat protein, Ci, cubitus interruptus, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Crosstalk, FBXO3/31, F-box protein 3/31, 0303 health sciences, biology, KEAP1, kelch like ECH associated protein 1, Kinase, Chemistry, KBTBD8, kelch repeat and BTB domain containing 8, CSN, COP9 signalosome, DYRK1A/B, dual-specificity tyrosine-phosphorylation-regulated kinases 1A/B, FBW7, F-box and WD repeat domain containing 7, CDT2, denticleless E3 ubiquitin protein ligase homolog, NRF2, nuclear factor, erythroid 2 like 2, TCN, triciribine hydrate, Cell biology, USP37, ubiquitin specific peptidase 37, Crosstalk (biology), XBP1, X-box binding protein 1, 030220 oncology & carcinogenesis, HCC, hepatocellular carcinomas, Vps34, phosphatidylinositol 3-kinase catalytic subunit type 3, CK1/2, casein kinase I/II, COMMD1, copper metabolism domain containing 1, KLHL3, kelch like family member 3, EMT, epithelial–mesenchymal transition, Cullin, P-TEFb, positive transcription elongation factor b, CDK2/4, cyclin dependent kinase 2/4, SPOP, speckle-type POZ protein, AIRE, autoimmune regulator, PYGO2, pygopus 2, TCOF1, treacle ribosome biogenesis factor 1, ID2, inhibitor of DNA binding 2, CHK1, checkpoint kinase 1, Kinases, FZR1, fizzy and cell division cycle 20 related 1, HIF1α, NF-κB and hypoxia inducible factor 1 subunit alpha, EXO1, exonuclease 1, ZBTB16, zinc finger and BTB domain containing 16, NOLC1, nucleolar and coiled-body phosphoprotein 1, 03 medical and health sciences, PKM2, pyruvate kinase M2 isoform, KDM2B, lysine demethylase 2B, PKC, protein kinase C, Cullin-RING ligases, medicine, BMAL1, aryl hydrocarbon receptor nuclear translocator like, ATR, ataxia telangiectasia-mutated and Rad3-related, SOCS6, suppressor of cytokine signaling 6, 030304 developmental biology, PDL1, programmed death ligand 1, HIB, Hedghog-induced MATH and BTB domain-containing protein, AKT, AKT serine/threonine kinase, lcsh:RM1-950, Ubiquitination, TRF1, telomeric repeat binding factor 1, DDB1, damage specific DNA binding protein 1, BCL2, BCL2 apoptosis regulator, CLOCK, clock circadian regulator, MYC, MYC proto-oncogene, bHLH transcription factor, lcsh:Therapeutics. Pharmacology, c-Fos, Fos proto-oncogene, AP-1 transcription factor subunit, RARα, RA receptor α, Tumorigenesis, biology.protein, Suppressor, CRY1, cryptochrome circadian regulator 1, ERG, ETS transcription factor ERG, Carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27b7f488f3a53677836e1b8e5b2722dTest
https://doi.org/10.1016/j.apsb.2020.09.007Test

4

Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in MiceSummary

المؤلفون: Caroline Richard, Jean Buteau, John P. Kennelly, Tingting Ju, Stephanie Carlin, Ben P. Willing, Jelske N. van der Veen, Aducio Thiesen, René L. Jacobs, Randal Nelson

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 999-1021 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, CTαIKO, intestinal epithelial cell–specific deletion of CTP:phosphocholine cytidylyltransferase-α, TNF-α, tumor necrosis factor-α, IEC, intestinal epithelial cell, PC, phosphatidylcholine, Mice, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Homeostasis, Intestinal Mucosa, Original Research, Mice, Knockout, Chemistry, IRE1α, inositol-requiring enzyme 1-α, LIF, leukemia inhibitory factor, Dextran Sulfate, Gastroenterology, MCP-1, monocyte chemoattractant protein-1, Lipid, CTα, CTP:phosphocholine cytidylyltransferase-α, Colitis, Endoplasmic Reticulum Stress, Intestinal epithelium, mRNA, messenger RNA, 3. Good health, rRNA, ribosomal RNA, XBP1, X-box binding protein 1, medicine.anatomical_structure, RIP, receptor-interacting serine/threonine-protein kinase, Necroptosis, Phosphatidylcholines, Female, 030211 gastroenterology & hepatology, FITC, fluorescein isothiocyanate, Goblet Cells, GM-CSF, granulocyte-macrophage colony-stimulating factor, ATF6, activating transcription factor 6, Colon, PE, phosphatidylethanolamine, Permeability, ER, endoplasmic reticulum, 03 medical and health sciences, medicine, Animals, Choline-Phosphate Cytidylyltransferase, IBD, inflammatory bowel diseases, lcsh:RC799-869, Inflammation, Goblet cell, Intestinal permeability, Mouse Model, Hepatology, PERK, protein kinase R-like ER kinase, Endoplasmic reticulum, medicine.disease, Molecular biology, Mucus, Epithelium, IL, interleukin, Gastrointestinal Microbiome, Mice, Inbred C57BL, UC, ulcerative colitis, Phosphatidylcholine, 030104 developmental biology, TUNEL, terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling, lcsh:Diseases of the digestive system. Gastroenterology, CDP, cytidine diphosphate, PBA, 4-phenyl butyrate

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cb572fe2a00cfe78b75990b8fc2494Test
http://www.sciencedirect.com/science/article/pii/S2352345X20301855Test

5

Suppression of CCDC6 sensitizes tumor to oncolytic virus M1

المؤلفون: Guangmei Yan, Ying Liu, Jiankai Liang, Ke Li, Xincheng Liu, Wentao Huang, Cheng Hu, Yuan Lin, Jing Cai, Hao Zhang, Liang Peng, Wenbo Zhu, Jianguang Qiu

المصدر: Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 158-168 (2021)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Oncolytic virus, ISG, interferon-stimulated genes, viruses, Gene Expression, Apoptosis, CCDC6, Coiled-coil-domain containing 6, Mice, 0302 clinical medicine, Interferon pathway, Neoplasms, DNA-PKI, DNA-PK inhibitor, RNA, Small Interfering, Oncolytic Virotherapy, Gene knockdown, M1 virus, HRP, horseradish peroxidase, Transfection, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Endoplasmic Reticulum Stress, ZAP, zinc finger antiviral protein, Oncolytic Viruses, XBP1, X-box binding protein 1, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, RT, room temperature, Oncolytic Virus Therapy, Female, Original article, DAUCs, area under the curve, PVDF, polyvinylidene fluoride, siRNA, Small interfering RNAs, Genetic Vectors, Alphavirus, Biology, lcsh:RC254-282, Virus, 03 medical and health sciences, DNA-PK, DNA-dependent protein kinase, Cell Line, Tumor, Animals, Humans, Genetic Therapy, biology.organism_classification, Xenograft Model Antitumor Assays, IFNs, Interferons, VCP, valosin-containing protein, Cytoskeletal Proteins, Disease Models, Animal, 030104 developmental biology, CCDC6, Cancer cell, Cancer research, ATM, ataxia telangiectasia-mutated

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fdcd32c851e4b9811b639d74f6d69a3Test
https://doi.org/10.1016/j.neo.2020.12.003Test

6

Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis

المؤلفون: Mingyang Shao, Qing Xu, Menglin Chen, Xiaoyue Cao, Chuan Li, Hong Bu, Yuwei Chen, Yuke Shu, Zhenru Wu, Gang Guo, Yuping Gong, Yongjie Zhou, Yujun Shi

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 633-651 (2021)

مصطلحات موضوعية: Male, 0301 basic medicine, Adenosine, FoxM1, forkhead box M1, IRE1α, inositol requiring enzyme 1 alpha, XBP1, X-box-binding protein 1, STAT, signal transducers and activators of transcription, RNA Stability, Mettl3, methyltransferase-like 3, Alkbh5, ALKB family member 5 protein, Apoptosis, RC799-869, AST, aspartate aminotransferase, WTAP, Wilms’ tumor 1-associated protein, Endoplasmic Reticulum, UPR, unfolded protein response, 0302 clinical medicine, ERK, extracellular signal-regulated kinase, Homeostasis, TUDCA, tauroursodeoxycholate, BrdU, 5-bromo-2-deoxyuridine, eIF2α, eukaryotic translation initiator factor 2α, Original Research, Mice, Knockout, N6-methyladenosine, Chemistry, Gastroenterology, PI3K, phosphatidylinositol 3-kinase, Methylation, Diseases of the digestive system. Gastroenterology, Cell cycle, Endoplasmic Reticulum Stress, Liver regeneration, Cell biology, UTR, untranslated region, medicine.anatomical_structure, Liver, PHx, partial hepatectomy, Organ Specificity, Hepatocyte, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, FTO, fat mass and obesity-associated protein, ATF6, activating transcription factor 6, AMPK, adenosine 5′-monophosphate-activated protein kinase, JAK, janus kinase, ER, endoplasmic reticulum, Taurochenodeoxycholic Acid, PAS, periodic acid–Schiff, Necrosis, 03 medical and health sciences, ALT, alanine aminotransferase, TM, tunicamycin, medicine, Act D, actinomycin, Animals, Hepatectomy, RNA, Messenger, Cell Proliferation, Messenger RNA, Hepatology, Endoplasmic reticulum, CDS, coding sequence, Mettl14, Methyltransferases, FC, fold change, m6A, N6-methyladenosine, WT, wild-type, Liver Regeneration, m6A-seq, m6A sequencing, 030104 developmental biology, MRNA Sequencing, Hepatocytes, Unfolded protein response, EIF3A, eukaryotic translation initiation factor 3 subunit A, HCC, hepatocellular carcinoma, Peptides, Transcriptome, PERK, protein kinase R-like endoplasmic reticulum kinase, Chop, C/EBP-homologous protein, MAPK, mitogen-activated protein kinase, Gene Deletion