رسالة جامعية
In vitro methods to study the digestion and absorption of substances in the gastro-intestinal tract
| العنوان: | In vitro methods to study the digestion and absorption of substances in the gastro-intestinal tract |
|---|---|
| المؤلفون: | Everaars, L., Student, Hutter, C., Horst, G., Strikwold, M., Oudhuis, A.A.C.M., Woudstra, F.S., Hogeschool Van Hall Larenstein, Applied Research Center, Hogeschool Van Hall Larenstein |
| بيانات النشر: | Leeuwarden: VHL, 2023. |
| سنة النشر: | 2023 |
| وصف مادي: | 54 p. |
| مصطلحات موضوعية: | Melkvee, Dierproeven, Proefdieren |
| الوصف: | Alternatives to animal testing are increasingly being used to assess the toxicological safety of substances and medicines, with a great deal of focus in recent years on alternatives for humans and small laboratory animals. Cattle, however, are also used for veterinary medicine research and education, but no complete alternative for testing with cattle is available so far. In analogue for rat and human, in vitro and in silico models could be developed for the cow as an alternative for animal testing. However, reliance on in vitro data entails a number of new challenges associated with translating the in vitro results to corresponding in vivo values. The RAAK-PRO project 'Generic bovine kinetic modelling platform, works on developing an in silico in vitro based model to predict the transfer of substances from feed to food (milk and meat from the cow) without testing in living cows. For this purpose, several in vitro assays for absorption are being developed. The aim of this study was to set-up a Caco-2 permeability assay to predict in vivo oral uptake values for the cow. Besides this, the application of an in vitro tiny-TIM digestion system for probiotic survival in the human GI-tract was studied, which can be used as an alternative for human studies. |
| نوع الوثيقة: | bachelor Thesis |
| اللغة: | English |
| الوصول الحر: | https://www.greeni.nl/iguana/CMS.MetaDataEditDownload.cls?file=2:150844:1Test https://www.greeni.nl/iguana/www.main.cls?surl=greenisearch#RecordId=2.150844Test |
| الإتاحة: | http://www.hbo-kennisbank.nl/en/page/hborecord.view/?uploadId=samhao:oai:www.greeni.nl:VBS:2:150844Test |
| رقم الانضمام: | edshbo.samhao.oai.www.greeni.nl.VBS.2.150844 |
| قاعدة البيانات: | HBO Kennisbank |
| الوصف غير متاح. |