المؤلفون: Judith Klumperman, Tineke Veenendaal, Arthur J. Verhoeven, Marc J. Tol, Wilma E. Donker-Koopman, Johannes M. F. G. Aerts, Jacob Hagen, Saskia Scheij, Carmen Argmann, Martijn J.C. van der Lienden, Marco van Eijk, Hermen S. Overkleeft, Tanit L. Gabriel

المساهمون: Other departments, Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, Tytgat Institute for Liver and Intestinal Research, Amsterdam Cardiovascular Sciences, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes

المصدر: Autophagy, 14(3), 437-449. Landes Bioscience
Autophagy
Autophagy, 14(3), 437-449

مصطلحات موضوعية: 0301 basic medicine, MiT/TFE, Autophagy, cell culture, mTORC1, Biology, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Lysosome, Autophagy, medicine, Humans, Gene Regulatory Networks, Molecular Biology, PI3K/AKT/mTOR pathway, HEPES, Microphthalmia-Associated Transcription Factor, cell culture, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Cell growth, MTOR, Research Papers - Basic Science, Cell Biology, Cell biology, 030104 developmental biology, medicine.anatomical_structure, chemistry, Cell culture, lysosome, Lysosomes, metabolism, Biogenesis, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa2455e671819669ada8b7a5e0fe53f5Test
https://pure.amc.nl/en/publications/hepes-activates-a-mittfedependent-lysosomalautophagic-gene-network-in-cultured-cells-a-call-for-cautionTest(2dc148fe-8d83-424a-ae70-46d8ce4fa343).html

المؤلفون: Sascha Hoogendoorn, Hans van den Elst, Gijsbert A. van der Marel, Richard J. B. H. N. van den Berg, Anneke Strijland, Johannes M. F. G. Aerts, Elliot D. Mock, Wilma E. Donker-Koopman, Herman S. Overkleeft

المصدر: European Journal of Organic Chemistry. 2015:4437-4446

مصطلحات موضوعية: chemistry.chemical_classification, Inhibitory potency, Enzyme, chemistry, Stereochemistry, Organic Chemistry, Carborane, Glucosylceramide synthase, Physical and Theoretical Chemistry, Glucosylceramidase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::e7811e99f07322d0c9f445fc424c232eTest
https://doi.org/10.1002/ejoc.201500364Test

المؤلفون: Adrianus M. C. H. van den Nieuwendijk, Daniel Mink, Veronica Coco Rohde, Gijsbert A. van der Marel, Jianbing Jiang, Daniel W. Wright, Bogdan I. Florea, Johannes M. F. G. Aerts, Gideon J. Davies, Wouter W. Kallemeijn, Hans van den Elst, Wilma E. Donker-Koopman, Martin Schürmann, Nan Li, Rolf G. Boot, Saskia Scheij, Marri Verhoek, Jeroen D. C. Codée, Herman S. Overkleeft, Elisa Colomina Folch

المساهمون: Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, ACS - Amsterdam Cardiovascular Sciences

المصدر: CHEMICAL SCIENCE, 6(5), 2782-2789. Royal Society of Chemistry
Chemical Science, 6(5), 2782-2789

مصطلحات موضوعية: biology, genetic structures, 010405 organic chemistry, Stereochemistry, Chemistry, Activity-based proteomics, Active site, Stereoisomerism, General Chemistry, 010402 general chemistry, medicine.disease, biology.organism_classification, 01 natural sciences, Fucosidosis, In vitro, 0104 chemical sciences, 3. Good health, Biochemistry, In vivo, Hydrolase, medicine, biology.protein, Bacteria

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c1b0655d1799327f935b9d7fee32e0Test
https://doi.org/10.1039/c4sc03739aTest

المؤلفون: Anneke Strijland, Amar B. T. Ghisaidoobe, Maria J. Ferraz, Tom Wennekes, Gijsbert A. van der Marel, Erwin R. van Rijssel, Johannes M. F. G. Aerts, Sascha Hoogendoorn, Herman S. Overkleeft, Wilma E. Donker-Koopman, Kimberly M. Bonger, Jeroen D. C. Codée, Judith H.P.M. Houben, Richard J. B. H. N. van den Berg

المساهمون: Graduate School, Amsterdam Cardiovascular Sciences, Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry

المصدر: ChemMedChem, 10(12), 2042. John Wiley and Sons Ltd
ChemMedChem : chemistry enabling drug discovery 10 (2015) 12
ChemMedChem : chemistry enabling drug discovery, 10(12), 2042-2062
ChemMedChem, 10(12), 2042-2062. John Wiley and Sons Ltd

مصطلحات موضوعية: glucosylceramide synthase, Ceramide, 1-Deoxynojirimycin, Convergent synthesis, Biology, Ceramides, Biochemistry, Isozyme, Inhibitory Concentration 50, Structure-Activity Relationship, Pharmacology, Toxicology and Pharmaceutics(all), chemistry.chemical_compound, Drug Discovery, Humans, Life Science, Structure–activity relationship, neutral glucosylceramidase, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, VLAG, chemistry.chemical_classification, Pharmacology, Glucosamine, acid glucosylceramidase, Organic Chemistry, Organische Chemie, Glucosylceramidase, Isoenzymes, Enzyme, Toxicology and Pharmaceutics(all), chemistry, Glucosyltransferases, ceramide analogues, deoxynojirimycin, Molecular Medicine, Eliglustat, Protein Binding

وصف الملف: application/pdf; application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e8efb22414a42f400dad27904710dfTest
https://doi.org/10.1002/cmdc.201500407Test

المؤلفون: Saskia Scheij, Richard J. B. H. N. van den Berg, Wilma E. Donker-Koopman, Mark Leemhuis, Anneke Strijland, Tom Wennekes, Saleem S Butt, Amar B. T. Ghisaidoobe, Gijsbert A. van der Marel, Herman S. Overkleeft, Arnold van Loevezijn, Mario van der Stelt, Constant A. A. van Boeckel, Gerrit-Jan Koomen, Adrianus M. C. H. van den Nieuwendijk, Johannes M. F. G. Aerts

المساهمون: Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, Amsterdam Cardiovascular Sciences

المصدر: Journal of medicinal chemistry, 57(21), 9096-9104. American Chemical Society

مصطلحات موضوعية: 1-Deoxynojirimycin, Stereochemistry, Chemistry, beta-Glucosidase, Biphenyl Compounds, Glucosylceramide synthase, Lysosomal storage disorders, Metabolic stability, Imino Sugars, Glucosylceramidase, Biochemistry, Glucosyltransferases, Drug Discovery, Humans, Molecular Medicine, Enzyme Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d656b24065d8c0333320542ef08a724fTest
https://doi.org/10.1021/jm501181zTest

المؤلفون: Rolf G. Boot, Bogdan I. Florea, Jeroen D. C. Codée, Wilma E. Donker-Koopman, Benjamin Murray, Saskia Scheij, Wouter W. Kallemeijn, Marri Verhoek, Herman S. Overkleeft, Johannes M. F. G. Aerts, Thomas J. M. Beenakker, Gijsbert A. van der Marel, Lianne I. Willems, Maria J. Ferraz, Erwin R. van Rijssel

المساهمون: Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, Graduate School, Amsterdam Cardiovascular Sciences

المصدر: Journal of the American Chemical Society, 136(33), 11622-11625. American Chemical Society

مصطلحات موضوعية: Cell type, Aziridines, Endogeny, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, 03 medical and health sciences, Structure-Activity Relationship, Colloid and Surface Chemistry, α galactosidase, medicine, Structure–activity relationship, Humans, 030304 developmental biology, Fluorescent Dyes, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, General Chemistry, medicine.disease, Fabry disease, 0104 chemical sciences, 3. Good health, alpha-Galactosidase, Active enzyme

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1757c3ffcec39116e9bfc8ac48e3911Test
https://doi.org/10.1021/ja507040nTest

المؤلفون: Johannes M. F. G. Aerts, Marri Verhoek, Timothy M. Cox, Elena Pavlova, Wilma E. Donker-Koopman, Rolf G. Boot, Jessica K. Nelson, Gert Jan Kramer, Wouter W. Kallemeijn, Mary Teresa Moran, Wouter Wegdam, Roelof Ottenhoff, Jon D. Laman, Marco van Eijk, Paulo Gaspar, Tanit L. Gabriel, Johannes P. C. Vissers

المساهمون: Cox, Timothy [0000-0002-4951-9941], Pavlova, Elena [0000-0003-0187-5098], Apollo - University of Cambridge Repository, Molecular Neuroscience and Ageing Research (MOLAR), Translational Immunology Groningen (TRIGR), Other departments, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity

المصدر: FEBS Open Bio
FEBS Open Bio, 6(9), 902-913. Wiley-Blackwell
FEBS Open Bio, 6(9), 902-913. Wiley Open Access
FEBS open bio, 6(9), 902-913. Wiley-Blackwell

مصطلحات موضوعية: 0301 basic medicine, DC-HIL, EXPRESSION, GLUCOCEREBROSIDASE, Pathology, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Genetic enhancement, Cell, DC‐HIL, Biology, storage disease, PHENOTYPE, osteoactivin, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chitotriosidase, Lysosome, glucosylceramide, medicine, CELL, Research Articles, GPNMB, PLASMA, CCL18, GENE-THERAPY, nutritional and metabolic diseases, FORMATION IN-VIVO, Phenotype, 3. Good health, MARKED ELEVATION, nervous system diseases, 030104 developmental biology, medicine.anatomical_structure, DIFFERENTIATION, lysosome, Biomarker (medicine), Glucocerebrosidase, Research Article

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9904b801f366cbc06c3d1033778f123cTest
https://www.repository.cam.ac.uk/handle/1810/289591Test

المؤلفون: Amar B. T. Ghisaidoobe, Herman S. Overkleeft, Tom Wennekes, Johannes M. F. G. Aerts, Gijsbert A. van der Marel, Richard J. B. H. N. van den Berg, Wilma E. Donker-Koopman, Rolf G. Boot, Anneke Strijland

المساهمون: AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, ACS - Amsterdam Cardiovascular Sciences

المصدر: ACS medicinal chemistry letters, 2(7), 519-522. American Chemical Society
ACS Medicical Chemistry Letters 2 (2011) 7
ACS Medicical Chemistry Letters, 2(7), 519-522

مصطلحات موضوعية: Drug, 1-deoxynojirimycin derivatives, Ceramide, storage disorders, Glucosylceramide Synthase Inhibitors, media_common.quotation_subject, Iminosugar, Glucosylceramide synthase, Biochemistry, chemistry.chemical_compound, Drug Discovery, gaucher disease, glycolipid biosynthesis, insulin sensitivity, Medicine, VLAG, media_common, chemistry.chemical_classification, business.industry, Organic Chemistry, Insulin sensitivity, asymmetric-synthesis, Organische Chemie, glycosyltransferase inhibitors, chiral building-block, Enzyme, chemistry, nonlysosomal glucosylceramidase, GCS Inhibitors, business, n-butyldeoxynojirimycin

وصف الملف: application/pdf; application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b6733dc64247d59fc415f8f82691f7Test
https://doi.org/10.1021/ml200050sTest

المؤلفون: Arjan C. J. de Bruijn, Frithjof D. Godschalk, Marieke C. Guijt, Peter Hagens, Rolf G. Boot, Anneke Strijland, Amar B. T. Ghisaidoobe, Mark Wijzenbroek, Steven M. van't Hart, Gijs A. van der Marel, Eva Rogaar, Johannes M. F. G. Aerts, Wilma E. Donker-Koopman, Vincent H. S. van Rixel, Herman S. Overkleeft, Stijn B. Luitjens, Richard J. B. H. N. van den Berg, Jerre M. Halma, Pieter Bikker, Thor Zweegers

المساهمون: Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry, Amsterdam Cardiovascular Sciences

المصدر: ACS medicinal chemistry letters, 2(2), 119-123. American Chemical Society

مصطلحات موضوعية: chemistry.chemical_classification, Glucosylceramide Synthase Inhibitors, business.industry, Organic Chemistry, Iminosugar, Glucosylceramide synthase, Alkylation, Biochemistry, Glucosylceramidase, Enzyme, Drug development, chemistry, Drug Discovery, Medicine, Chemical chaperone, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdef980a9afc1194d9b941d6bb0267dTest
https://doi.org/10.1021/ml100192bTest

المؤلفون: Richard J. B. H. N. van den Berg, Tom Wennekes, Bastiaan Kuijper, Johannes M. F. G. Aerts, Thomas J. Boltje, Wilma E. Donker-Koopman, Anneke Strijland, Gijsbert A. van der Marel, Carlo P. Verhagen, Herman S. Overkleeft

المساهمون: ACS - Amsterdam Cardiovascular Sciences, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Medical Biochemistry

المصدر: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2010(7), 1258-1283. Wiley-VCH Verlag

مصطلحات موضوعية: chemistry.chemical_classification, biology, Chemistry, Stereochemistry, Organic Chemistry, Iminosugar, Sphingolipid, Chemical synthesis, Glycolipid, Enzyme, Enzyme inhibitor, biology.protein, Moiety, Physical and Theoretical Chemistry, Linker

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b58b655d6006d688eb53f88b87f4515eTest
https://doi.org/10.1002/ejoc.200901208Test