نتائج البحث - "Wightman, Melanie"

1

تقرير

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

المؤلفون: Raimi, Olawale G., Ojha, Hina, Ehses, Kenneth, Dederer, Verena, Lange, Sven M., Rivera, Cristian Polo, Deegan, Tom D., Chen, Yinchen, Wightman, Melanie, Toth, Rachel, Labib, Karim P. M., Mathea, Sebastian, Ranson, Neil, Fernández-Busnadiego, Rubén, Muqit, Miratul M. K.

المساهمون: Raimi, Olawale G., Ojha, Hina, Ehses, Kenneth, Dederer, Verena, Lange, Sven M., Rivera, Cristian Polo, Deegan, Tom D., Chen, Yinchen, Wightman, Melanie, Toth, Rachel, Labib, Karim P. M., Mathea, Sebastian, Ranson, Neil, Fernández-Busnadiego, Rubén, Muqit, Miratul M. K.

العلاقة: EXC 2067: Multiscale Bioimaging; https://resolver.sub.uni-goettingen.de/purl?gro-2/142415Test; https://mbexc.uni-goettingen.de/literature/publications/917Test

الإتاحة: https://doi.org/10.1101/2023.12.23.573181Test
https://resolver.sub.uni-goettingen.de/purl?gro-2/142415Test
https://mbexc.uni-goettingen.de/literature/publications/917Test

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2

دورية أكاديمية

An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation

المؤلفون: Simpson, Luke M., Fulcher, Luke J., Sathe, Gajanan, Brewer, Abigail, Zhao, Jin-Feng, Squair, Daniel R., Crooks, Jennifer, Wightman, Melanie, Wood, Nicola T., Gourlay, Robert, Varghese, Joby, Soares, Renata F., Sapkota, Gopal P.

المصدر: Simpson , L M , Fulcher , L J , Sathe , G , Brewer , A , Zhao , J-F , Squair , D R , Crooks , J , Wightman , M , Wood , N T , Gourlay , R , Varghese , J , Soares , R F & Sapkota , G P 2023 , ' An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation ' , Cell Chemical Biology , vol. 30 , no. 2 , pp. 188-202 . https://doi.org/10.1016/j.chembiol.2023.01.003Test

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/b0ee5ed6-6d18-4e15-bd77-1c5b5ba96ccaTest

الإتاحة: https://doi.org/10.1016/j.chembiol.2023.01.003Test
https://discovery.dundee.ac.uk/en/publications/b0ee5ed6-6d18-4e15-bd77-1c5b5ba96ccaTest
https://discovery.dundee.ac.uk/ws/files/96764889/1_s2.0_S2451945623000260_main.pdfTest
http://www.scopus.com/inward/record.url?scp=85148030514&partnerID=8YFLogxKTest

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3

دورية أكاديمية

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain

المؤلفون: Malik, Asad U, Karapetsas, Athanasios, Nirujogi, Raja S, Chatterjee, Deep, Phung, Toan K, Wightman, Melanie, Gourlay, Robert, Morrice, Nick, Mathea, Sebastian, Knapp, Stefan, Alessi, Dario R

العلاقة: https://zenodo.org/communities/asaphubTest; https://zenodo.org/record/6621049Test; https://doi.org/10.5281/zenodo.6621049Test; oai:zenodo.org:6621049

الإتاحة: https://doi.org/10.5281/zenodo.6621049Test
https://doi.org/10.5281/zenodo.6621048Test
https://zenodo.org/record/6621049Test

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4

دورية أكاديمية

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain

المؤلفون: Malik, Asad U., Karapetsas, Athanasios, Nirujogi, Raja S., Chatterjee, Deep, Phung, Toan K., Wightman, Melanie, Gourlay, Robert, Morrice, Nicholas A., Mathea, Sebastian, Knapp, Stefan, Alessi, Dario R.

المصدر: Malik , A U , Karapetsas , A , Nirujogi , R S , Chatterjee , D , Phung , T K , Wightman , M , Gourlay , R , Morrice , N A , Mathea , S , Knapp , S & Alessi , D R 2022 , ' PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR B GTPase domain ' , Biochemical Journal , vol. 479 , no. 18 , pp. 1941-1965 . https://doi.org/10.1042/BCJ20220308Test

مصطلحات موضوعية: leucine rich repeat kinase, protein kinases C, GTPases, RAB, Rab GTPases, protein kinase C, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/6aa517fb-0958-44df-bad8-04c6b3ad5d1aTest

الإتاحة: https://doi.org/10.1042/BCJ20220308Test
https://discovery.dundee.ac.uk/en/publications/6aa517fb-0958-44df-bad8-04c6b3ad5d1aTest
https://discovery.dundee.ac.uk/ws/files/85131487/bcj_2022_0308.pdfTest
http://www.scopus.com/inward/record.url?scp=85139375165&partnerID=8YFLogxKTest

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5

دورية أكاديمية

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

المؤلفون: Kalogeropulou, Alexia F., Purlyte, Elena, Tonelli, Francesca, Lange, Sven M., Wightman, Melanie, Prescott, Alan R., Padmanabhan, Shalini, Sammler, Esther, Alessi, Dario R.

المصدر: Biochemical Journal ; volume 479, issue 17, page 1759-1783 ; ISSN 0264-6021 1470-8728

الإتاحة: https://doi.org/10.1042/bcj20220161Test
https://portlandpress.com/biochemj/article-pdf/479/17/1759/936843/bcj-2022-0161.pdfTest

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6

دورية أكاديمية

Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B

المؤلفون: Pal, Prosenjit, Taylor, Matthew, Lam, Pui Yiu, Tonelli, Francesca, Hecht, Chloe A., Lis, Pawel, Nirujogi, Raja S., Phung, Toan K., Yeshaw, Wondwossen M., Jaimon, Ebsy, Fasimoye, Rotimi, Dickie, Emily A., Wightman, Melanie, Macartney, Thomas, Pfeffer, Suzanne R., Alessi, Dario R.

المصدر: Science Advances ; volume 9, issue 50 ; ISSN 2375-2548

الإتاحة: https://doi.org/10.1126/sciadv.adj1205Test

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7

دورية أكاديمية

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

المؤلفون: Malik, Nazma, Nirujogi, Raja S., Peltier, Julien, Macartney, Thomas, Wightman, Melanie, Prescott, Alan, Gourlay, Robert, Trost, Matthias, Alessi, Dario, Karapetsas, Athanasios

المصدر: Malik , N , Nirujogi , R S , Peltier , J , Macartney , T , Wightman , M , Prescott , A , Gourlay , R , Trost , M , Alessi , D & Karapetsas , A 2019 , ' Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44 ' , Biochemical Journal , vol. 476 , no. 20 , pp. 3081-3107 . https://doi.org/10.1042/BCJ20190608Test

مصطلحات موضوعية: SGK3, Phosphoproteomics, phosphoinositide 3-kinase, Akt, syntaxins, /dk/atira/pure/subjectarea/asjc/1300/1312, name=Molecular Biology, /dk/atira/pure/subjectarea/asjc/1300/1303, name=Biochemistry, /dk/atira/pure/subjectarea/asjc/1300/1307, name=Cell Biology

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/0bf4cbe6-d818-4803-812d-cc00c5c401b5Test

الإتاحة: https://doi.org/10.1042/BCJ20190608Test
https://discovery.dundee.ac.uk/en/publications/0bf4cbe6-d818-4803-812d-cc00c5c401b5Test
https://discovery.dundee.ac.uk/ws/files/39515722/bcj_2019_0608.pdfTest
http://www.scopus.com/inward/record.url?scp=85074247777&partnerID=8YFLogxKTest

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8

دورية أكاديمية

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

المؤلفون: Berndsen, Kerryn, Lis, Pawel, Yeshaw, Wondwossen M, Wawro, Paulina S, Nirujogi, Raja S, Wightman, Melanie, Macartney, Thomas, Dorward, Mark, Knebel, Axel, Tonelli, Francesca, Pfeffer, Suzanne R, Alessi, Dario R

المساهمون: Michael J. Fox Foundation for Parkinson's Research, Medical Research Council, National Institutes of Health

المصدر: eLife ; volume 8 ; ISSN 2050-084X

الإتاحة: https://doi.org/10.7554/elife.50416Test
https://cdn.elifesciences.org/articles/50416/elife-50416-v2.pdfTest
https://cdn.elifesciences.org/articles/50416/elife-50416-v2.xmlTest
https://elifesciences.org/articles/50416Test

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9

دورية أكاديمية

Rab29 activation of the Parkinson's disease‐associated LRRK 2 kinase

المؤلفون: Purlyte, Elena, Dhekne, Herschel S, Sarhan, Adil R, Gomez, Rachel, Lis, Pawel, Wightman, Melanie, Martinez, Terina N, Tonelli, Francesca, Pfeffer, Suzanne R, Alessi, Dario R

المصدر: The EMBO Journal ; volume 38, issue 2 ; ISSN 0261-4189 1460-2075

مصطلحات موضوعية: General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, Molecular Biology, General Neuroscience

الإتاحة: https://doi.org/10.15252/embj.2018101237Test

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10

دورية أكاديمية

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

المؤلفون: Purlyte, Elena, Dhekne, Herschel S., Sarhan, Adil R., Gomez, Rachel, Lis, Pawel, Wightman, Melanie, Martinez, Terina N., Tonelli, Francesca, Pfeffer, Suzanne R., Alessi, Dario R.

المصدر: Purlyte , E , Dhekne , H S , Sarhan , A R , Gomez , R , Lis , P , Wightman , M , Martinez , T N , Tonelli , F , Pfeffer , S R & Alessi , D R 2018 , ' Rab29 activation of the Parkinson's disease-associated LRRK2 kinase ' , EMBO Journal , vol. 37 , no. 1 , pp. 1-18 . https://doi.org/10.15252/embj.201798099Test

مصطلحات موضوعية: Golgi, GTPase, PARK genes, Phosphorylation, Rab10

وصف الملف: application/pdf

العلاقة: https://discovery.dundee.ac.uk/en/publications/b1d1080b-3b9f-49cf-be0b-cb838abbb268Test

الإتاحة: https://doi.org/10.15252/embj.201798099Test
https://discovery.dundee.ac.uk/en/publications/b1d1080b-3b9f-49cf-be0b-cb838abbb268Test
https://discovery.dundee.ac.uk/ws/files/19742612/embj.201798099.full.pdfTest

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