نتائج البحث - "Wiebke Theilmann"

المساهمون: Laboratory of Neurobiology, Molecular and Integrative Biosciences Research Programme, Physiology and Neuroscience (-2020), Kai Kaila / Principal Investigator, Neuroscience Center

مصطلحات موضوعية: 0301 basic medicine, BRAIN-DEVELOPMENT, congenital, hereditary, and neonatal diseases and abnormalities, PHARMACOKINETICS, HYPOXIA, CHILDREN, INTRANASAL, 03 medical and health sciences, GABA, 0302 clinical medicine, Pharmacokinetics, medicine, NKCC1, Asphyxia, business.industry, ANTIEPILEPTIC DRUGS, 3112 Neurosciences, Hypoxia (medical), medicine.disease, EFFICACY, neonates, 3. Good health, Perinatal asphyxia, 030104 developmental biology, Neurology, Anesthesia, Midazolam, Phenobarbital, Nasal administration, Neurology (clinical), CATION-CHLORIDE COTRANSPORTERS, PENETRATION, medicine.symptom, business, antiseizure drugs, 030217 neurology & neurosurgery, Bumetanide, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a6801fabde75fe31b03d45d3645e14Test
http://hdl.handle.net/10138/333660Test

5

Dose-dependent effects of isoflurane on TrkB and GSK3β signaling: Importance of burst suppression pattern

المؤلفون: Tomi Rantamäki, Iris Yorke, Wiebke Theilmann, Okko Alitalo

المساهمون: Molecular and Integrative Biosciences Research Programme, Division of Pharmacology and Pharmacotherapy, Laboratory of Neurotherapeutics, Drug Research Program

المصدر: Neuroscience Letters. 694:29-33

مصطلحات موضوعية: Male, 0301 basic medicine, Antidepressant, Tropomyosin receptor kinase B, ACTIVATION, EEG burst suppression, 0302 clinical medicine, GSK-3, BRAIN, PHOSPHORYLATION, Prefrontal cortex, Electrocerebral silence, Membrane Glycoproteins, Isoflurane, biology, Chemistry, General Neuroscience, Electroencephalography, Protein-Tyrosine Kinases, GLYCOGEN-SYNTHASE KINASE-3, DEPRESSION, Antidepressive Agents, Burst suppression, 317 Pharmacy, Anesthetics, Inhalation, MOUSE HIPPOCAMPUS, Signal transduction, Signal Transduction, medicine.drug, Neurotrophin, medicine.medical_specialty, Prefrontal Cortex, NARCOTHERAPY, CREB, 03 medical and health sciences, Protein phosphorylation, Internal medicine, medicine, Animals, ANESTHESIA, Glycogen Synthase Kinase 3 beta, Dose-Response Relationship, Drug, 3112 Neurosciences, Mice, Inbred C57BL, NEUROTROPHIN RECEPTOR, 030104 developmental biology, Endocrinology, biology.protein, 3111 Biomedicine, 030217 neurology & neurosurgery, ELECTROCONVULSIVE SHOCK

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e3c9e2f4b64af91bd02ef2ac9f813dTest
https://doi.org/10.1016/j.neulet.2018.11.018Test

6

Hydrolytic biotransformation of the bumetanide ester prodrug DIMAEB to bumetanide by esterases in neonatal human and rat serum and neonatal rat brain : A new treatment strategy for neonatal seizures?

المؤلفون: Martina Gramer, Markus Kalesse, Claudia Brandt, Andi Kipper, Anne-Mieke Winstroth, Anibh M. Das, Wiebke Theilmann, Bettina Bohnhorst, Wolfgang Löscher

المصدر: Epilepsia 62 (2021), Nr. 1

مصطلحات موضوعية: 0301 basic medicine, Drug, Male, Serum, medicine.drug_class, media_common.quotation_subject, phenobarbital, Pharmacology, Blood–brain barrier, 03 medical and health sciences, 0302 clinical medicine, Pharmacotherapy, BUM5, medicine, NKCC1, Animals, Humans, Prodrugs, ddc:610, Bumetanide, media_common, business.industry, Esterases, Infant, Newborn, Brain, Esters, ontogenesis, Loop diuretic, Prodrug, blood-brain barrier, carboxylesterase, Rats, 030104 developmental biology, medicine.anatomical_structure, Neurology, Animals, Newborn, Phenobarbital, Female, Neurology (clinical), Dewey Decimal Classification::600 | Technik::610 | Medizin, Gesundheit, business, 030217 neurology & neurosurgery, Intracellular, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adc06a21f5f186839f53abaf34ce308Test
https://www.repo.uni-hannover.de/handle/123456789/10757Test

7

Novel brain permeant mTORC1/2 inhibitors are as efficacious as rapamycin or everolimus in mouse models of acquired partial epilepsy and tuberous sclerosis complex

المؤلفون: Dean J. Aguiar, Wiebke Theilmann, Birthe Gericke, Syed Muhammad Muneeb Anjum, Steven C. Leiser, Dekun Song, Timon Harries, Matthias P. Wymann, Daniela Brunner, Petra Hillmann, Alina Schidlitzki, Steven L. Roberds, Doriano Fabbro, Saskia Borsdorf, Wolfgang Löscher

المصدر: Neuropharmacology. 180

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f01263eaf3cea6c090d192c62bd9d53Test
https://pubmed.ncbi.nlm.nih.gov/32890589Test

8

Lack of antidepressant effects of burst-suppressing isoflurane anesthesia in adult male Wistar outbred rats subjected to chronic mild stress

المؤلفون: Tomi Rantamäki, Wiebke Theilmann, Marko Rosenholm, Wolfgang Löscher, Philip Hampel

المساهمون: INDIVIDRUG - Individualized Drug Therapy, Laboratory of Neurotherapeutics, Division of Pharmacology and Pharmacotherapy, Drug Research Program, SLEEPWELL Research Program

المصدر: PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0235046 (2020)

مصطلحات موضوعية: Male, Sucrose, medicine.medical_treatment, Social Sciences, 0302 clinical medicine, Anesthesiology, Psychology, Anesthesia, BRAIN, Mammals, Isoflurane, Depression, Organic Compounds, Eukaryota, Antidepressants, Antidepressive Agents, Bioassays and Physiological Analysis, Anesthetics, Inhalation, Physical Sciences, Medicine, Elevated plus maze, Imaging Techniques, Science, Carbohydrates, Neurophysiology, Anxiolytic, 03 medical and health sciences, Drug Therapy, Humans, Rats, Wistar, Pharmacology, Depressive Disorder, Behavior, Mood Disorders, KETAMINE, Brain-Derived Neurotrophic Factor, 3112 Neurosciences, Organisms, Chemical Compounds, Biology and Life Sciences, BDNF, 030104 developmental biology, Animal Studies, Clinical Medicine, 030217 neurology & neurosurgery, Neuroscience, 0301 basic medicine, Physiology, Hippocampus, Disaccharides, Open field, ELECTROCONVULSIVE-THERAPY, ACTIVATION, Electroconvulsive therapy, Neurotrophic factors, Medicine and Health Sciences, Electroconvulsive Therapy, Clinical Neurophysiology, Electroshock, Brain Mapping, Multidisciplinary, Animal Behavior, AMPA RECEPTOR, Pharmaceutics, Drugs, Electroencephalography, Animal Models, Electrophysiology, Chemistry, Experimental Organism Systems, Brain Electrophysiology, Vertebrates, medicine.drug, Research Article, EXPRESSION, medicine.drug_class, Prefrontal Cortex, Neuroimaging, Research and Analysis Methods, Rodents, Model Organisms, Mental Health and Psychiatry, medicine, Animals, Ketamine, MESSENGER-RNAS, business.industry, Organic Chemistry, Electrophysiological Techniques, TRKB NEUROTROPHIN RECEPTOR, RESISTANT MAJOR DEPRESSION, Rats, Disease Models, Animal, Amniotes, business, Zoology, Stress, Psychological

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53c0ec1993a224b581c2672d4495addTest
https://pubmed.ncbi.nlm.nih.gov/32579566Test

9

Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites

المؤلفون: Tomi Rantamäki, Jari Yli-Kauhaluoma, Gregers Wegener, Samuel Kohtala, Heidi Kaastrup Müller, Paula Kiuru, Marko Rosenholm, Wiebke Theilmann

المساهمون: Division of Pharmacology and Pharmacotherapy, Laboratory of Neurotherapeutics, Drug Research Program, Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, Faculty of Pharmacy, SLEEPWELL Research Program, Medicum, Pharmaceutical Design and Discovery group, Division of Pharmaceutical Chemistry and Technology, Jari Yli-Kauhaluoma / Principal Investigator

المصدر: Kohtala, S, Theilmann, W, Rosenholm, M, Müller, H K, Kiuru, P, Wegener, G, Yli-Kauhaluoma, J & Rantamäki, T 2019, ' Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites ', Neuropharmacology, vol. 157, 107684, pp. 107684 . https://doi.org/10.1016/j.neuropharm.2019.107684Test

مصطلحات موضوعية: Male, 0301 basic medicine, Hydroxynorketamine, Slow oscillations, ISOFLURANE-ANESTHESIA, Antidepressant, Tropomyosin receptor kinase B, PREFRONTAL CORTEX, Pharmacology, ELECTROCONVULSIVE-THERAPY, Mice, 0302 clinical medicine, Hypnotics and Sedatives, Anesthesia, Phosphorylation, Membrane Glycoproteins, Chemistry, AMPA RECEPTOR, DELTA-EEG, Brain, Electroencephalography, Protein-Tyrosine Kinases, 3. Good health, 317 Pharmacy, Sedation, embryonic structures, NMDA receptor, TREATMENT-RESISTANT DEPRESSION, Ketamine, medicine.symptom, Signal Transduction, medicine.drug, animal structures, ANTIDEPRESSANT ACTIONS, AMPA receptor, 03 medical and health sciences, Cellular and Molecular Neuroscience, medicine, Animals, Glycogen Synthase Kinase 3 beta, Dose-Response Relationship, Drug, Antagonist, 3112 Neurosciences, NITROUS-OXIDE, TRKB NEUROTROPHIN RECEPTOR, Brain Waves, 030104 developmental biology, nervous system, S-KETAMINE, Anesthetic, 030217 neurology & neurosurgery, Synaptosomes

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fae2fe946a51de315c04ed3a78bfec6Test
http://hdl.handle.net/10138/304547Test

10

Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson′s disease

المؤلفون: Markus M. Forsberg, Samuel Kohtala, Tomi Rantamäki, Wiebke Theilmann, Aaro J. Jalkanen, Juuso V. Leikas

المساهمون: School of Pharmacy, Activities, Biosciences, Laboratory of Neurotherapeutics

المصدر: Journal of Neurochemistry

مصطلحات موضوعية: Male, 0301 basic medicine, ALPHA-SYNUCLEIN, Nigrostriatal pathway, Striatum, Biochemistry, PATHWAY, Glycogen Synthase Kinase 3, chemistry.chemical_compound, 0302 clinical medicine, sensorimotor test, BRAIN, NEUROPROTECTION, Molecular Basis of Disease, Isoflurane, phosphorylation, Neurodegeneration, neurodegeneration, Parkinson Disease, GLYCOGEN-SYNTHASE KINASE-3, 3. Good health, Substantia Nigra, Neuroprotective Agents, medicine.anatomical_structure, Anesthesia, Original Article, dopamine, Oxidopamine, Signal Transduction, medicine.drug, animal structures, INHIBITION, Substantia nigra, anesthesia, 03 medical and health sciences, Cellular and Molecular Neuroscience, Dopamine, medicine, Animals, Rats, Wistar, Tyrosine hydroxylase, business.industry, Dopaminergic Neurons, 3112 Neurosciences, medicine.disease, Cyclic AMP-Dependent Protein Kinases, Corpus Striatum, Disease Models, Animal, 030104 developmental biology, nervous system, chemistry, Nerve Degeneration, HIPPOCAMPUS, 1182 Biochemistry, cell and molecular biology, ORIGINAL ARTICLES, business, 030217 neurology & neurosurgery, ELECTROCONVULSIVE SHOCK

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b5efd09dce610be179be1feb9278d2Test
https://doi.org/10.1111/jnc.14066Test

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