المؤلفون: Salvini, Catherine L. A., Darlot, Benoit, Davison, Jack, Martin, Mathew P., Tudhope, Susan J., Turberville, Shannon, Kawamura, Akane, Noble, Martin E. M., Wedge, Stephen R., Crawford, James J., Waring, Michael J.

المساهمون: Genentech, Engineering and Physical Sciences Research Council, Cancer Research UK, BD, Horizon 2020

المصدر: Chemical Science ; volume 14, issue 31, page 8288-8294 ; ISSN 2041-6520 2041-6539

الإتاحة: https://doi.org/10.1039/d3sc01171bTest
http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01171BTest

المؤلفون: Miller, Duncan C., Harnor, Suzannah J., Martin, Mathew P., Noble, Richard A., Wedge, Stephen R., Cano, Celine

المساهمون: Medical Research Council, Cancer Research UK

المصدر: Journal of Medicinal Chemistry ; volume 66, issue 7, page 4491-4502 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00072Test

المؤلفون: Morese, Pasquale A., Anthony, Nahoum, Bodnarchuk, Michael, Jennings, Claire, Martin, Mathew P., Noble, Richard A., Phillips, Nicole, Thomas, Huw D., Wang, Lan Z., Lister, Andrew, Noble, Martin E. M., Ward, Richard A., Wedge, Stephen R., Stewart, Hannah L., Waring, Michael J.

المساهمون: AstraZeneca, Engineering and Physical Sciences Research Council, Cancer Research UK

المصدر: Journal of Medicinal Chemistry ; volume 66, issue 17, page 12324-12341 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c00845Test

المؤلفون: Miller, Duncan C, Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy, Cook, Simon J, Edwards, Noel, Endicott, Jane A, Golding, Bernard T, Griffin, Roger J, Hardcastle, Ian, Harnor, Suzannah J, Heptinstall, Amy, Lochhead, Pamela, Martin, Mathew P, Martin, Nick C, Myers, Stephanie, Newell, David R, Noble, Richard A, Phillips, Nicole, Rigoreau, Laurent, Thomas, Huw, Tucker, Julie A, Wang, Lan-Zhen, Waring, Michael J, Wong, Ai-Ching, Wedge, Stephen R, Noble, Martin E, Cano, Celine

مصطلحات موضوعية: Chemistry

وصف الملف: application/pdf

العلاقة: http://sure.sunderland.ac.uk/id/eprint/14709/8/acs.jmedchem.1c01756.pdfTest; Miller, Duncan C , Reuillon, Tristan , Molyneux, Lauren , Blackburn, Timothy , Cook, Simon J , Edwards, Noel , Endicott, Jane A , Golding, Bernard T , Griffin, Roger J , Hardcastle, Ian , Harnor, Suzannah J , Heptinstall, Amy , Lochhead, Pamela , Martin, Mathew P , Martin, Nick C , Myers, Stephanie , Newell, David R , Noble, Richard A , Phillips, Nicole , Rigoreau, Laurent , Thomas, Huw , Tucker, Julie A , Wang, Lan-Zhen , Waring, Michael J , Wong, Ai-Ching , Wedge, Stephen R , Noble, Martin E and Cano, Celine (2022) Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. Journal of Medicinal Chemistry, 65 (9). pp. 6513-6540. ISSN 0022-2623

الإتاحة: http://sure.sunderland.ac.uk/id/eprint/14709Test/
http://sure.sunderland.ac.uk/id/eprint/14709/8/acs.jmedchem.1c01756.pdfTest

المؤلفون: Noble, Richard A., Thomas, Huw, Zhao, Yan, Herendi, Lili, Howarth, Rachel, Dragoni, Ilaria, Keun, Hector C., Vellano, Christopher P., Marszalek, Joseph R., Wedge, Stephen R.

المساهمون: Cancer Research UK

المصدر: British Journal of Cancer ; volume 127, issue 5, page 937-947 ; ISSN 0007-0920 1532-1827

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1038/s41416-022-01848-wTest
https://www.nature.com/articles/s41416-022-01848-w.pdfTest
https://www.nature.com/articles/s41416-022-01848-wTest

المؤلفون: Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E. M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.

المصدر: Chemistry and Biology. 22(9):1159-1164

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-268711Test
https://doi.org/10.1016/j.chembiol.2015.07.018Test
https://uu.diva-portal.org/smash/get/diva2:878807/FULLTEXT01.pdfTest

المؤلفون: Willoughby, Catherine E., Jiang, Yanyan, Thomas, Huw D., Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J., Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M. Raymond V., Turner, Paul, Munck, Joanne M., Griffin, Roger J., Rennison, Tommy, Pickles, James, Cano, Celine, Newell, Herbie, Reeves, Helen L., Ryan, Anderson J., Wedge, Stephen R.

وصف الملف: application/pdf

العلاقة: http://sure.sunderland.ac.uk/id/eprint/12742/1/Selective%20DNA-PKcs.pdfTest; Willoughby, Catherine E., Jiang, Yanyan, Thomas, Huw D., Willmore, Elaine, Kyle, Suzanne, Wittner, Anita, Phillips, Nicole, Zhao, Yan, Tudhope, Susan J., Prendergast, Lisa, Junge, Gesa, Lourenco, Luiza Madia, Finlay, M. Raymond V., Turner, Paul, Munck, Joanne M., Griffin, Roger J., Rennison, Tommy, Pickles, James, Cano, Celine, Newell, Herbie, Reeves, Helen L., Ryan, Anderson J. and Wedge, Stephen R. (2019) Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy. Journal of Clinical Investigation, 130 (1). pp. 258-271. ISSN 0021-9738

الإتاحة: https://doi.org/10.1172/JCI127483Test
http://sure.sunderland.ac.uk/id/eprint/12742Test/
http://sure.sunderland.ac.uk/id/eprint/12742/1/Selective%20DNA-PKcs.pdfTest

المؤلفون: Tucker, Julie Ann, Myers, Stephanie M., Miller, Duncan C., Molyneux, Lauren, Arasta, Mercedes, Bawn, Ruth H., Blackburn, Timothy J., Cook, Simon J., Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hammonds, Tim, Hardcastle, Ian R., Harnor, Suzannah J., Heptinstall, Amy B., Lochhead, Pamela A., Martin, Mathew P., Martin, Nick C., Newell, David R., Owen, Paul J., Pang, Leon C., Reuillon, Tristan, Rigoreau, Laurent J.M., Thomas, Huw D., Wang, Lan-Zhen, Wong, Ai-Ching, Noble, Martin E.M., Wedge, Stephen R., Cano, Celine

وصف الملف: text

العلاقة: https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest; Tucker, Julie Ann orcid.org/0000-0002-6119-676X , Myers, Stephanie M., Miller, Duncan C. et al. (27 more authors) (2019) Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4. European Journal of Medicinal Chemistry. pp. 530-543. ISSN 0223-5234

الإتاحة: https://doi.org/10.1016/j.ejmech.2019.05.057Test
https://eprints.whiterose.ac.uk/148098Test/
https://eprints.whiterose.ac.uk/148098/1/ERK5LeadIDPaper_EurJMedChem_2019_04_29.docxTest

المؤلفون: Sharma, Ricky A., Plummer, Ruth, Stock, Julie K., Greenhalgh, Tessa A., Ataman, Ozlem, Kelly, Stephen, Clay, Robert, Adams, Richard A., Baird, Richard D., Billingham, Lucinda, Brown, Sarah R., Buckland, Sean, Bulbeck, Helen, Chalmers, Anthony J., Clack, Glen, Cranston, Aaron N., Damstrup, Lars, Ferraldeschi, Roberta, Forster, Martin D., Golec, Julian, Hagan, Russell M., Hall, Emma, Hanauske, Axel-R., Harrington, Kevin J., Haswell, Tom, Hawkins, Maria A., Illidge, Tim, Jones, Hazel, Kennedy, Andrew S., McDonald, Fiona, Melcher, Thorsten, O'Connor, James P. B., Pollard, John R., Saunders, Mark P., Sebag-Montefiore, David, Smitt, Melanie, Staffurth, John, Stratford, Ian J., Wedge, Stephen R.

وصف الملف: text

العلاقة: http://eprints.gla.ac.uk/168118/1/168118.pdfTest; Sharma, R. A. et al. (2018) Clinical development of new drug–radiotherapy combinations. Nature Reviews Clinical Oncology , 13(10), pp. 627-642. (doi:10.1038/nrclinonc.2016.79 ) (PMID:27245279)

الإتاحة: https://doi.org/10.1038/nrclinonc.2016.79Test
http://eprints.gla.ac.uk/168118Test/
http://eprints.gla.ac.uk/168118/1/168118.pdfTest

المؤلفون: Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine

المساهمون: Cancer Research UK

المصدر: Organic & Biomolecular Chemistry ; volume 16, issue 11, page 1843-1850 ; ISSN 1477-0520 1477-0539

الإتاحة: https://doi.org/10.1039/c8ob00099aTest
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00099ATest