دورية أكاديمية
Human Parainfluenza Virus Type 1 Evolution Combines Cocirculation of Strains and Development of Geographically Restricted Lineages
| العنوان: | Human Parainfluenza Virus Type 1 Evolution Combines Cocirculation of Strains and Development of Geographically Restricted Lineages |
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| المؤلفون: | Hetherington, Seth V., Watson, Ann S., Scroggs, Ruth A., Portner, Allen |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1994 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Major Articles |
| الوصف: | The hemagglutinin neuraminidase (HN) glycoprotein of human parainfluenza virus type 1 (HPIV-1) mediates attachment to the host cell and is the target of protective antibody. Since the efficacy of a potential vaccine depends on antigenic constancy, the antigenic and genetic stability of the HPIV-l HN glycoprotein was examined for 13 isolates obtained between 1981 and 1989. Antigenic analysis with a panel of 11 monoclonal antibodies demonstrated a single change among 3 isolates from 1989 that distinguished them from all other isolates. The HN genes from all 13 isolates and 13 previously published HN gene sequences shared >95% homology. Evolutionary analysis demonstrated cocirculation of strains, without a dominant lineage. The 1989 isolates and the previously proposed subtype A isolates occupied distinct evolutionary branches, indicating geographically limited evolution. The slow rate of evolution and HN homogeneity may allow development of a single vaccine formulation for the prevention of disease. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://jid.oxfordjournals.org/cgi/content/short/169/2/248Test; http://dx.doi.org/10.1093/infdis/169.2.248Test |
| DOI: | 10.1093/infdis/169.2.248 |
| الإتاحة: | https://doi.org/10.1093/infdis/169.2.248Test http://jid.oxfordjournals.org/cgi/content/short/169/2/248Test |
| حقوق: | Copyright (C) 1994, Infectious Diseases Society of America |
| رقم الانضمام: | edsbas.605A7CB7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/169.2.248 |
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