المؤلفون: Elhage, Rima, Kelly, Mairead, Goudin, Nicolas, Megret, Jérôme, Legrand, Agnès, Nemazanyy, Ivan, Patitucci, Cécilia, Quellec, Véronique, Wai, Timothy, Hamaï, Ahmed, Ezine, Sophie

المساهمون: Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Plateforme d'Imagerie Cellulaire SFR Necker, Structure Fédérative de Recherche Necker (UAR 3633 / US24), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Plateforme de Cytométrie SFR Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Biologie Mitochondriale / Mitochondrial Biology, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This work was supported by core funding from the INSERM, CNRS, the University Paris Descartes and the Secular Society (TSS). AH wassupported by grants from la ligue nationale contre le cancer and the Comité de Paris de la ligue contre le cancer.

المصدر: ISSN: 1664-3224.

مصطلحات موضوعية: thymus, T cell progenitors, b-selection checkpoint, mitochondrial dynamics, metabolome, glycolysis, OxPhos Frontiers in Immunology frontiersin.org 01, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38288115; pasteur-04529642; https://pasteur.hal.science/pasteur-04529642Test; https://pasteur.hal.science/pasteur-04529642/documentTest; https://pasteur.hal.science/pasteur-04529642/file/Mitochondrial%20dynamics%20and%20metabolic%20regulation%20control%20T%20cell%20fate%20in%20the%20thymus.%20Tim.pdfTest; PUBMED: 38288115; PUBMEDCENTRAL: PMC10822881

الإتاحة: https://doi.org/10.3389/fimmu.2023.1270268Test
https://pasteur.hal.science/pasteur-04529642Test
https://pasteur.hal.science/pasteur-04529642/documentTest
https://pasteur.hal.science/pasteur-04529642/file/Mitochondrial%20dynamics%20and%20metabolic%20regulation%20control%20T%20cell%20fate%20in%20the%20thymus.%20Tim.pdfTest

المؤلفون: Patitucci, Cecilia, Hernández-Camacho, Juan Diego, Vimont, Elodie, Yde, Sonny, Cokelaer, Thomas, Chaze, Thibault, Giai Gianetto, Quentin, Matondo, Mariette, Gazi, Anastasia, Nemazanyy, Ivan, Stroud, David A., Hock, Daniella H., Donnarumma, Erminia, Wai, Timothy

المصدر: Nature Communications ; volume 14, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41467-023-44143-9Test
https://www.nature.com/articles/s41467-023-44143-9.pdfTest
https://www.nature.com/articles/s41467-023-44143-9Test

المؤلفون: Saunders, Nell, Monel, Blandine, Cayet, Nadège, Archetti, Lorenzo, Moreno, Hugo, Jeanne, Alexandre, Marguier, Agathe, Buchrieser, Julian, Wai, Timothy, Schwartz, Olivier, Fréchin, Mathieu

المصدر: Nature Communications; 6/11/2024, Vol. 15 Issue 1, p1-15, 15p

مصطلحات موضوعية: SARS-CoV-2, BAYESIAN analysis, CELL populations, ARTIFICIAL intelligence, VIRAL replication, ORGANELLES, POST-translational modification

المؤلفون: Wai, Timothy.

الإتاحة: http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=40735Test

المؤلفون: Wai, Timothy

مرشدي الرسالة: Eric Alan Shoubridge (Supervisor)

مصطلحات موضوعية: Biology - Genetics

العلاقة: Pid: 40735

الإتاحة: https://escholarship.mcgill.ca/concern/theses/jw827d293Test

المؤلفون: Donnarumma, Erminia, Kohlhaas, Michael, Vimont, Elodie, Kornobis, Etienne, Chaze, Thibault, Gianetto, Quentin Giai, Matondo, Mariette, Moya-Nilges, Maryse, Maack, Christoph, Wai, Timothy

المساهمون: G5 Biologie mitochondriale – Mitochondrial biology, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University Hospital of Würzburg, Biomics (plateforme technologique), Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Proteomics Core Facility (Protim), Université de Rennes (UR)-Plateforme Génomique Santé Biogenouest®, Plateforme BioImagerie Ultrastructurale – Ultrastructural BioImaging Platform (UTechS UBI), Institut Pasteur Paris (IP), T.W. is supported by the European Research Council (ERC) Starting Grant No. 714472 (Acronym “Mitomorphosis”), Fondation pour la Recherche Medicale (MND202003011475), and the Agence Nationale pour la Recherche (ANR-20-CE14-0039-02). C. M. is supported by the German Research Foundation (DFG, SFB 894, TRR-219, Ma 2528/7-1) and the German Federal Ministry of Education and Research (BMBF, 01EO1504)., We thank Pierre-Henri Commere and Sandrine Schmutz for flow cytometry services at the Institut Pasteur and Anastasia Gazi for electron microscopy services. We thank Corinne Lesaffre at the Paris Cardiovascular Research Center for the histology services, Anu Susan Kurian and Priscilla Lopes for technical assistance. We thank Sylvie Fabrega of the Viral Vector for Gene Transfer core facility of Structure Fédérative de Recherche Necker, Université de Paris for lentiviral particle synthesis and Nils-Göran Larsson for providing mitoYFP mice. We thank Arnaud Mourier for inciteful discussions on bioenergetics and Marie Lemesle for excellent administrative assistance., ANR-20-CE14-0039,LiMiT-CKD,Lipocalin-2 et Dysfonctionnement Mitochondrial: role dans la Maladie Rénale Chronique(2020), European Project: 714472,ERC-2016-STG,Mitomorphosis(2017)

المصدر: ISSN: 2041-1723.

مصطلحات موضوعية: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36333300; info:eu-repo/grantAgreement//714472/EU/Metabolic regulation of mitochondrial morphology/Mitomorphosis; pasteur-03853858; https://pasteur.hal.science/pasteur-03853858Test; https://pasteur.hal.science/pasteur-03853858/documentTest; https://pasteur.hal.science/pasteur-03853858/file/Erminia.pdfTest; PUBMED: 36333300; PUBMEDCENTRAL: PMC9636241

الإتاحة: https://doi.org/10.1038/s41467-022-34316-3Test
https://pasteur.hal.science/pasteur-03853858Test
https://pasteur.hal.science/pasteur-03853858/documentTest
https://pasteur.hal.science/pasteur-03853858/file/Erminia.pdfTest

المؤلفون: Pujol, Claire, Lebigot, Elise, Gaignard, Pauline, Galai, Said, Kraoua, Ichraf, Bault, Jean-Philippe, Dard, Rodolphe, Youssef-Turki, Ilhem Ben, Omar, Souheil, Boutron, Audrey, Wai, Timothy, Slama, Abdelhamid

المساهمون: G5 Biologie mitochondriale – Mitochondrial biology, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Saclay, Université de Tunis El Manar (UTM), CHI Poissy-Saint-Germain, T.W. is supported by the European Research Council (ERC) Starting Grant No. 714472 (Acronym ‘Mitomorphosis’). T.W. and C.P are supported by the French National Center for Scientific Research (CNRS). E.L., P.G. and A.S. are supported by the AMMI ‘Association contre les Maladies MItochondriales’. S.G is supported by Tunisian Ministry of High Education and Scientific Research through the Junior Project ‘Jeune Enseignant Chercheur PJEC’., European Project: 714472,ERC-2016-STG,Mitomorphosis(2017)

المصدر: ISSN: 0006-8950.

مصطلحات موضوعية: mitochondria pyruvate carrier metabolism, mitochondria, pyruvate carrier, metabolism, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36417180; info:eu-repo/grantAgreement//714472/EU/Metabolic regulation of mitochondrial morphology/Mitomorphosis; pasteur-03934309; https://pasteur.hal.science/pasteur-03934309Test; https://pasteur.hal.science/pasteur-03934309/documentTest; https://pasteur.hal.science/pasteur-03934309/file/MPC2.pdfTest; PUBMED: 36417180

الإتاحة: https://doi.org/10.1093/brain/awac444Test
https://pasteur.hal.science/pasteur-03934309Test
https://pasteur.hal.science/pasteur-03934309/documentTest
https://pasteur.hal.science/pasteur-03934309/file/MPC2.pdfTest

المؤلفون: Donnarumma, Erminia, Kohlhaas, Michael, Vimont, Elodie, Kornobis, Etienne, Chaze, Thibault, Giai Gianetto, Quentin, Matondo, Mariette, Moya-Nilges, Maryse, Maack, Christoph, Wai, Timothy

المساهمون: G5 Biologie mitochondriale – Mitochondrial biology, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University Clinic Würzburg, Biomics (plateforme technologique), Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Plateforme de Spectrométrie de Masse Protéomique - Mass Spectrometry Proteomics Platform (MSPP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Montpellier (UM)

المصدر: https://pasteur.hal.science/pasteur-03853920Test ; 2022.

مصطلحات موضوعية: mitochondria, cardiomyopathy, oxidative phosphorylation, uncoupling, permeability transition pore, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

العلاقة: pasteur-03853920; https://pasteur.hal.science/pasteur-03853920Test; https://pasteur.hal.science/pasteur-03853920/documentTest; https://pasteur.hal.science/pasteur-03853920/file/Erminia%20BIOXRIV.pdfTest; BIORXIV: 2021.10.21.465262

الإتاحة: https://doi.org/10.1101/2021.10.21.465262Test
https://pasteur.hal.science/pasteur-03853920Test
https://pasteur.hal.science/pasteur-03853920/documentTest
https://pasteur.hal.science/pasteur-03853920/file/Erminia%20BIOXRIV.pdfTest

المؤلفون: Kleele, Tatjana, Rey, Timo, Winter, Julius, Zaganelli, Sofia, Mahecic, Dora, Perreten Lambert, Hélène, Ruberto, Francesco, Paolo, Nemir, Mohamed, Wai, Timothy, Pedrazzini, Thierry, Manley, Suliana, Ruberto, Francesco Paolo

المساهمون: Ecole Polytechnique Fédérale de Lausanne (EPFL), Experimental Cardiology Unit, Université de Lausanne = University of Lausanne (UNIL), G5 Biologie mitochondriale – Mitochondrial biology, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), We thank C. Cottiny and M. Colomer for experimental and technical assistance, M.-C. Croisier and G. Knott from the BioEM (EPFL) for carrying out the electron microscopy, T. Laroche (BIOP, EPFL) for imaging support and M. Ryan for the MEF lines. We thank T. Misgeld, J.-C. Martinou and P. Ramdya for feedback on the manuscript. Research in S.M.’s laboratory is supported by the National Centre of Competence in Research Chemical Biology, the European Research Council (CoG 819823, Piko) and the Swiss National Science Foundation (182429). T.K. received funding from the European Molecular Biology Organization (ALTF-739-2016) and the Munich Cluster for Systems Neurology (SyNergy). This work is supported in part by grants from the Swiss National Science Foundation to T.P. (no. CRSII5_173738 and no. 31003A_182322)., European Project: 819823,ERC-2018-COG,Piko(2019)

المصدر: ISSN: 0028-0836.

مصطلحات موضوعية: MESH: Actins, MESH: Animals, MESH: Cells, Cultured, MESH: Chlorocebus aethiops, MESH: DNA, Mitochondrial, MESH: Dynamins, MESH: Endoplasmic Reticulum, MESH: Humans, MESH: Lysosomes, MESH: Membrane Proteins, MESH: Mice, MESH: Mitochondria, MESH: Mitochondrial Dynamics, MESH: Mitochondrial Proteins, MESH: Mitophagy, MESH: COS Cells, MESH: Cell Survival, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33953403; info:eu-repo/grantAgreement//819823/EU/Revealing the adaptive internal organization and dynamics of bacteria and mitochondria/Piko; pasteur-03382143; https://pasteur.hal.science/pasteur-03382143Test; https://pasteur.hal.science/pasteur-03382143/documentTest; https://pasteur.hal.science/pasteur-03382143/file/Kleele%20et%20al_2021.pdfTest; PUBMED: 33953403

الإتاحة: https://doi.org/10.1038/s41586-021-03510-6Test
https://pasteur.hal.science/pasteur-03382143Test
https://pasteur.hal.science/pasteur-03382143/documentTest
https://pasteur.hal.science/pasteur-03382143/file/Kleele%20et%20al_2021.pdfTest

المؤلفون: Spier, Anna, Connor, Michael, Steiner, Thomas, Carvalho, Filipe, Cossart, Pascale, Eisenreich, Wolfgang, Wai, Timothy, Stavru, Fabrizia

المساهمون: Biologie Évolutive de la Cellule Microbienne - Evolutionary Biology of the Microbial Cell, Université Paris Cité (UPCité)-Microbiologie Intégrative et Moléculaire (UMR6047), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Interactions Bactéries-Cellules, Institut Pasteur Paris (IP), Chromatine et Infection - Chromatin and Infection, Institut Pasteur Paris (IP)-Université Paris Cité (UPCité), Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM), Université Paris Cité (UPCité), G5 Biologie mitochondriale – Mitochondrial biology, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This study was supported by the European Research Council ( H2020-ERC-2014-ADG 670823-BacCellEpi to P.C.), the DFG ( Project-ID EI 384/16-1 to W.E.), Institut Pasteur , and the Centre National de la Recherche Scientifique (CNRS). A.S. was supported by a BioSPC doctoral fellowship from the Université de Paris . M.G.C. is funded by a Pasteur Foundation Fellowship and his work was funded by ANR JCJC grant “Epibactin.”, We dedicate this work to the memory of Fabrizia Stavru. We thank Frédéric Bouillaud, Anne Lombès, and Nathalie Sauvonnet for useful advice, discussions, and support with Seahorse and endocytosis assays, Nam Tham for technical support, Werner Goebel for insightful discussions, Pierre-Henri Commere and members of the Cytometry & Biomarkers facility (CB_UTechS) at Institut Pasteur for training and help with flow cytometry and the Seahorse analyzer, and Alessandro Pagliuso and Simonetta Gribaldo for critical reading of the manuscript. Other bacterial species were GFP-expressing Salmonella enterica serovar Typhimurium strain 12023 (BUG2562) (a gift from Stéphane Méresse, Centre d’Immunologie de Marseille-Luminy, France) and Shigella flexneri M09T (BUG 2505) (a gift from Phillipe Sansonetti,Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, Paris). We thank Dr. Matthew Lawrenz at the University of Louisville for sharing the Rab11bCA construct generated by M.G.C. while in his laboratory., ANR-17-CE12-0007,EpiBactIn,Modifications epigenomiques induites par l'interaction hote-bacteries(2017), European Project: 670823,H2020,ERC-2014-ADG,BacCellEpi(2015)

المصدر: ISSN: 2211-1247.

مصطلحات موضوعية: mitochondria, metabolism, respiration, mitochondrial disease, infection, Listeria monocytogenes, endocytic recycling, Rab11, 13C isotopologue profiling, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34758302; info:eu-repo/grantAgreement//670823/EU/Bacterial, cellular and epigenetic factors that control enteropathogenicity/BacCellEpi; hal-03520503; https://hal.science/hal-03520503Test; https://hal.science/hal-03520503/documentTest; https://hal.science/hal-03520503/file/1-s2.0-S2211124721014686-main.pdfTest; PUBMED: 34758302; PUBMEDCENTRAL: PMC8595641; WOS: 000718279000007

الإتاحة: https://doi.org/10.1016/j.celrep.2021.109989Test
https://hal.science/hal-03520503Test
https://hal.science/hal-03520503/documentTest
https://hal.science/hal-03520503/file/1-s2.0-S2211124721014686-main.pdfTest