Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood
| العنوان: | Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood |
|---|---|
| المؤلفون: | Genette Ellis, Yasmin Iles-Caven, Rosie Clark, Joseph R. Hibbeln, Caroline M Taylor, Steve Gregory, Jean Golding |
| المصدر: | Golding, J, Gregory, S, Clark, R, Iles-Caven, Y L, Ellis, G L, Taylor, C M & Hibbeln, J R 2021, ' Maternal prenatal vitamin B12 intake is associated with speech development and mathematical abilities in childhood ', Nutrition Research, vol. 86, pp. 68-78 . https://doi.org/10.1016/j.nutres.2020.12.005Test Nutrition Research (New York, N.y.) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Pediatrics, Longitudinal study, Endocrinology, Diabetes and Metabolism, Intelligence, Aptitude, WASI, Wechsler Abbreviated Scale of Intelligence, DNA, Deoxyribonucleic acid, 0302 clinical medicine, Endocrinology, Cognition, Pregnancy, Mathematical ability, Longitudinal Studies, Child, Prenatal Nutritional Physiological Phenomena, Prenatal vitamins, Intelligence Tests, Nutrition and Dietetics, Intelligence quotient, Vitamins, SATS, Standardised Attainment Test Scores, ALSPAC, Vitamin B 12, Longitudinal cohort study, Prenatal Exposure Delayed Effects, WORD, Wechsler Objective Reading Dimension, Female, Vitamin B12, Cobalamin, medicine.medical_specialty, Science, 030209 endocrinology & metabolism, Language Development, Article, 03 medical and health sciences, WOLD, Wechsler Objective Language Dimension, medicine, Humans, Speech, Vitamin B12, Adverse effect, TOWRE, Test of Word Reading Efficiency, NARA II, Neale Analysis of Reading Ability, 030109 nutrition & dietetics, Mathematical Concepts, CDI, MacArthur Communicative Development Inventory, CCC, Children's Communication Checklist, medicine.disease, Diet, tHcy level, Homocysteine, IQ, Intelligence quotient, ALSPAC, Avon Longitudinal Study of Parents and Children, Reading, Mathematics, WISC, Wechsler Intelligence Scale for Children |
| الوصف: | Deficiencies of many nutrients in pregnancy have adverse effects on fetal brain development with consequent impaired cognitive function in childhood. However, it is unclear whether deficiencies of vitamin B12 prenatally are harmful to the developing fetus. We therefore used the Avon Longitudinal Study of Parents and Children to test the hypothesis that cognitive outcomes in childhood are reduced if their mothers consumed a diet low in vitamin B12 during pregnancy. A detailed exposome analysis was used to identify 9 factors independently associated with low vitamin B12 intake. These were taken into account in each of 26 outcome analyses. Results showed that the children of women with the lowest 10% intake of B12 were at increased risk of poor vocabulary at 24 months, reduced ability at combining words at 38 months, poor speech intelligibility at 6 years, poor mathematics comprehension at school years 4 and 6 (ages 8-9 and 10-11 years), and poor results on the national mathematics tests (age 13). There were no such significant adjusted associations for reading or spelling abilities, or for verbal or full-scale IQ (Intelligence Quotient) at 8 or at 15. Thus, we have confirmed that there are adverse effects on the child's development if the pregnant woman has a low intake of vitamin B12, and we have shown that these are specific to certain speech and mathematical abilities. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0965d782eade4719143b9607fd19f9eTest https://research-information.bris.ac.uk/en/publications/7dc0ac3d-f104-4b40-a679-2179931ee220Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a0965d782eade4719143b9607fd19f9e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |