نتائج البحث - "WD, Western diet"

1

Spontaneous Cholemia in C57BL/6 Mice Predisposes to Liver Cancer in NASH

المؤلفون: Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Diran Herebian, Mohammad M. Karimi, Elaine E. Irvine, Domhnall McHugh, Anne T. Schneider, Mihael Vucur, Verena Keitel, Jesús Gil, Dominic J. Withers, Tom Luedde, Mathias Heikenwalder

المساهمون: Wellcome Trust, Medical Research Council

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 875-878 (2022)

مصطلحات موضوعية: TBA, total bile acid, WD, Western diet, ALP, alkaline phosphatase, Hepatology, Liver Neoplasms, Gastroenterology, RC799-869, Diseases of the digestive system. Gastroenterology, H-TBA, high total bile acid, Mice, Inbred C57BL, Mice, Non-alcoholic Fatty Liver Disease, Research Letter, Animals, NASH, nonalcoholic steatohepatitis, L-TBA, low total bile acid

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d45aaed62a194a1c208368535ba0186Test
https://doi.org/10.1016/j.jcmgh.2021.11.012Test

2

Novel Göttingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

المؤلفون: Hunter A Hidalgo, Amy Scarborough, Zhen Li, Thomas E. Sharp, David J. Polhemus, J. Stephen Jenkins, Timothy Matsuura, Jeffery D. Schumacher, Daniel P. Kelly, David J. Lefer, Traci T. Goodchild

المصدر: JACC: Basic to Translational Science

مصطلحات موضوعية: heart failure with preserved ejection fraction, 0301 basic medicine, obesity, medicine.medical_specialty, animal models of human disease, hypertension, HDL, high-density lipoprotein, DBP, diastolic blood pressure, HFpEF, heart failure with preserved ejection fraction, Disease, DOCA, 11-deoxycorticosterone acetate, 030204 cardiovascular system & hematology, Novel Translational Models, metabolic syndrome, 03 medical and health sciences, PCWP - Pulmonary capillary wedge pressure, 0302 clinical medicine, LDL, low-density lipoprotein, Internal medicine, Western diet, medicine, EF, ejection fraction, HFrEF, heart failure with reduced ejection fraction, WD, Western diet, business.industry, SBP, systolic blood pressure, DBP - Diastolic blood pressure, medicine.disease, PCWP, pulmonary capillary wedge pressure, TC, total cholesterol, LV, left ventricle, 030104 developmental biology, Heart failure, IVGTT, intravenous glucose tolerance test, Cardiology, EC50, half-maximal effective concentration, Metabolic syndrome, Cardiology and Cardiovascular Medicine, Heart failure with preserved ejection fraction, business, Large animal

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1e0726e5da7045a1ac79cfd8108325Test
https://doi.org/10.1016/j.jacbts.2020.11.012Test

3

Sestrin Proteins Protect Against Lipotoxicity-Induced Oxidative Stress in the Liver via Suppression of C-Jun N-Terminal KinasesSummary

المؤلفون: Menghao Huang, Kushan Chowdhury, Zhigang Fang, X. Charlie Dong, Ming O. Li, Suthat Liangpunsakul, Hyeong-Geug Kim

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 921-942 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Sestrins, MPO, myeloperoxidase, Mitogen-Activated Protein Kinase Kinase 7, RC799-869, DMSO, dimethyl sulfoxide, FoxO, forkhead box O, Sesn1/2/3, sestrin1/2/3, medicine.disease_cause, TKO, triple knockout, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, GSH, glutathione, Phosphorylation, NF-κB, nuclear factor kappa B, Original Research, Cat, catalase, Mice, Knockout, Sestrin, Gpx3, glutathione peroxidase 3, Il6, interleukin 6, WD, Western diet, biology, Chemistry, Kinase, Fatty liver, Tgfbr1, transforming growth factor beta receptor 1, Gastroenterology, Col1a1, collagen type 1 alpha 1, Nox1, NADPH oxidase 1, Diseases of the digestive system. Gastroenterology, Dgat2, diacylglycerol O-acyltransferase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, C-Jun N-Terminal Kinase, Liver, Lipotoxicity, c-Jun N-terminal kinases, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, Disease Susceptibility, Signal transduction, NASH, nonalcoholic steatohepatitis, Gss, glutathione synthetase, Pdgfrb, platelet-derived growth factor receptor beta, Timp1, tissue inhibitor of metalloproteinase 1, Fasn, fatty acid synthase, Fatty Liver Disease, Sod, superoxide dismutase, Acta2, smooth muscle actin alpha 2, ER, endoplasmic reticulum, PA, palmitic acid, 03 medical and health sciences, 4-HNE, 4-hydroxynonenal, MKK, mitogen-activated protein kinase kinase, medicine, Animals, Humans, Srebp, sterol regulatory element-binding protein, Protein kinase A, KD, knockdown, MDA, malondialdehyde, Inflammation, KO, knockout, Hepatology, NRF2, nuclear factor erythroid 2-related like 2, JNK Mitogen-Activated Protein Kinases, Lipid Metabolism, medicine.disease, Tgfb1, transforming growth factor beta 1, WT, wild-type, mTORC, mechanistic target of rapamycin complex, Fatty Liver, AMPK, AMP-activated protein kinase, Disease Models, Animal, Oxidative Stress, Scd1, stearoyl-CoA desaturase 1, 030104 developmental biology, Gene Expression Regulation, Cytoprotection, Hepatocytes, biology.protein, BSA, bovine serum albumin, SD, standard deviation, DHE, dihydroethidium, PERK, protein kinase R-like endoplasmic reticulum kinase, Tnf, tumor necrosis factor, Biomarkers, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574bc0f082fa7f7fd23bf88f6f9c6fcTest
http://www.sciencedirect.com/science/article/pii/S2352345X21000862Test

4

Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet

المؤلفون: Anthony M. Diomino, David A. Brenner, Hyeok Choon Kwon, Gibraan Rahman, Sara Brin Rosenthal, Tatiana Kisseleva, Linshan Shang, Souradipta Ganguly, Ruoyu Wang, Debanjan Dhar, Rob Knight, Pejman Soorosh, Mojgan Hosseini, Yanhan Wang, Bernd Schnabl, German R. Aleman Muench

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 891-920 (2021)
Cellular and molecular gastroenterology and hepatology, vol 12, iss 3

مصطلحات موضوعية: Cirrhosis, medicine.medical_treatment, Cell Cycle Proteins, RC799-869, Gastroenterology, Mice, 0302 clinical medicine, Fibrosis, Aetiology, Original Research, Cancer, Liver Disease, Liver Neoplasms, ILC, innate lymphoid cell, Diseases of the digestive system. Gastroenterology, Immunohistochemistry, HSC, hepatic stellate cell, DSI, distal small intestine, Editorial, FACS, fluorescence-activated cell sorter, 030211 gastroenterology & hepatology, FITC, fluorescein isothiocyanate, NASH, nonalcoholic steatohepatitis, Western, IHC, immunohistochemistry, medicine.medical_specialty, Carcinoma, Hepatocellular, Knockout, CVD, cardiovascular disease, Hyperphagia, digestive system, 03 medical and health sciences, Humans, RPCA, robust principal component analysis, Dyslipidemias, Animal, nutritional and metabolic diseases, Hepatocellular, PE, Phycoerythrin, Hepatocellular Carcinoma, Gene signature, medicine.disease, WT, wild-type, digestive system diseases, IL, interleukin, LBP, lipopolysaccharide binding protein, 030104 developmental biology, NAFLD, nonalcoholic fatty liver disease, MIP2, Macrophage Inflammatory Protein 2, Digestive Diseases, Biomarkers, Liver Inflammation, Liver Cirrhosis, 0301 basic medicine, Chemokine, CXCL2, C-X-C motif chemokine ligand 2, Adipose tissue, Nonalcoholic Steatohepatitis, Gut Inflammation, Oral and gastrointestinal, Hepatitis, Risk Factors, Non-alcoholic Fatty Liver Disease, 2.1 Biological and endogenous factors, Mice, Knockout, TNF, tumor necrosis factor, WD, Western diet, biology, rRNA, ribosomal RNA, Cytokine, Hepatocellular carcinoma, LPS, lipopolysaccharide, Disease Susceptibility, medicine.symptom, eWAT, white adipose tissue (epididymal fat), NASH Regression, Biotechnology, Liver Cancer, APC, Allophycocyanin, Chronic Liver Disease and Cirrhosis, PBS, phosphate-buffered saline, Inflammation, CD-HFD, choline-deficient high-fat diet, SI, small intestine, Rare Diseases, FBS, fetal bovine serum, ALT, alanine aminotransferase, Internal medicine, medicine, Animals, IFN, interferon, Obesity, Nutrition, Hepatology, business.industry, Gene Expression Profiling, CKD, chronic kidney disease, Carcinoma, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, Diet, Disease Models, Animal, Good Health and Well Being, Diet, Western, Disease Models, biology.protein, Insulin Resistance, HCC, hepatocellular carcinoma, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b88e146fb92107eb8ff000fbb198af7Test
https://doi.org/10.1016/j.jcmgh.2021.05.010Test

5

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate CellsSummary

المؤلفون: Romil Saxena, Wenjie Cai, Yang Zhang, Menghao Huang, Xiaolin Zhong, Kushan Chowdhury, Robert F. Schwabe, Suthat Liangpunsakul, Hyeong-Geug Kim, X. Charlie Dong

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 341-364 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Liver Cirrhosis, 0301 basic medicine, Steatosis, Nonalcoholic Steatohepatitis, Pathogenesis, PCR, polymerase chain reaction, 0302 clinical medicine, SMAD3, SMAD family member 3, Fibrosis, Sirtuin 6, Sirtuins, Original Research, GFP, green fluorescent protein, WD, Western diet, Fatty liver, Gastroenterology, SIRT6, sirtuin 6, HSC, hepatic stellate cell, mRNA, messenger RNA, ChIP, chromatin immunoprecipitation, Sirtuin, shRNA, short hairpin RNA, TGFB, transforming growth factor β, 030211 gastroenterology & hepatology, Lrat, lecithin retinol acyltransferase, medicine.symptom, NASH, nonalcoholic steatohepatitis, SIRT6, Deacetylation, PBS, phosphate-buffered saline, Inflammation, Biology, 03 medical and health sciences, ALT, alanine aminotransferase, Tg, transgenic, Hepatic Stellate Cells, medicine, Humans, lcsh:RC799-869, KO, knockout, Hepatology, medicine.disease, WT, wild-type, digestive system diseases, 030104 developmental biology, Cancer research, biology.protein, Hepatic stellate cell, DMEM, Dulbecco’s modified Eagle medium, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, HA, hemagglutinin, Transforming growth factor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e993c50fadc362faaa1fba27859fd85Test
http://www.sciencedirect.com/science/article/pii/S2352345X20300497Test

6

Antisense oligonucleotide–mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice

المؤلفون: Aaron J. Donner, Rosanne M. Crooke, Adam E. Mullick, Richard G. Lee, Mingxia Liu, Thomas A. Bell

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100101-(2021)

مصطلحات موضوعية: Endothelial lipase, antisense oligonucleotide, EL, endothelial lipase, Biochemistry, chemistry.chemical_compound, Mice, Endocrinology, ANGPTL3, cardiovascular disease, RCT, reverse cholesterol transport, Hyperlipidemia, hyperlipidemia, LOF, loss-of-function, chemistry.chemical_classification, Mice, Knockout, WD, Western diet, Reverse cholesterol transport, tg, transgenic, lipids (amino acids, peptides, and proteins), ASCVD, atherosclerotic cardiovascular disease, coronary artery disease, Research Article, medicine.medical_specialty, HDL, Transgene, ASO, antisense oligonucleotide, QD415-436, ANGPTL3, angiopoietin-like protein 3, TPC, total plasma cholesterol, lipids, Internal medicine, medicine, Animals, Humans, Loss function, Angiopoietin-Like Protein 3, LSC, liquid scintillation counting, 3H-CHE, 3H-cholesteryl hexadecyl ether, FCR, fractional catabolic rate, Cholesterol, Cholesterol, HDL, cholesterol, Biological Transport, Cell Biology, FHBL2, familial combined hypobetalipoproteinemia, Oligonucleotides, Antisense, medicine.disease, reverse cholesterol transport, Mice, Inbred C57BL, Enzyme, chemistry, atherosclerosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3dd6baedbaa871b44ae87791eadae9Test
http://europepmc.org/articles/PMC8417398Test

7

Making the Best of a Competition: the CREB3L3–SREBP Axis in Arteriosclerosis

المؤلفون: Tirthadipa Pradhan-Sundd

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1199-1201 (2021)

مصطلحات موضوعية: Male, Arteriosclerosis, SREBP, sterol regulatory element-binding protein, CREB3L3, FGF21, fibroblast growth factor 21, Bioinformatics, CREB3L3, cAMP responsive element-binding protein 3 like 3, Mice, Enterohepatic Circulation, Cyclic AMP Response Element-Binding Protein, Insig, insulin-induced gene, Original Research, GFP, green fluorescent protein, Mice, Knockout, Sterol Regulatory Element Binding Proteins, TBA, total bile acid, WD, Western diet, TG, triglyceride, Chemistry, Gastroenterology, Editorial, Hyperlipidemia, LPL, lipoprotein lipase, Female, lipids (amino acids, peptides, and proteins), Sterol Regulatory Element Binding Protein 1, HDL, high-density lipoprotein, Hyperlipidemias, SREBP, ER, endoplasmic reticulum, Competition (economics), Tg, transgenic, FFA, free fatty acid, medicine, Animals, Humans, lcsh:RC799-869, KO, knockout, PPARα, peroxisome proliferator-activated receptor alpha, Hepatology, PLA, proximity ligation assay, S1P, site-1 protease, Lipogenesis, SREBF, sterol regulatory element-binding factor, VLDL, very-low-density lipoprotein, Atherosclerosis, Lipid Metabolism, medicine.disease, Sterol regulatory element-binding protein, Mice, Inbred C57BL, TC, total cholesterol, Gene Expression Regulation, Receptors, LDL, Apo, apolipoprotein, HPLC, high-performance liquid chromatography, HSV, herpes simplex virus, lcsh:Diseases of the digestive system. Gastroenterology, LXR, liver X receptor