المؤلفون: Nada H. Eisa, Vincent M. Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A. Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T.F. Tsai, Paulo C. Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli

المصدر: iScience, Vol 26, Iss 12, Pp 108308- (2023)

مصطلحات موضوعية: Microenvironment, Biological sciences, Molecular biology, Cancer, Science

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2589004223023854Test; https://doaj.org/toc/2589-0042Test

الوصول الحر: https://doaj.org/article/f4ba062b1eb84919b99e30fb877c3d61Test

المؤلفون: Vincent M. Crowley, Marvin Thielert, Benjamin F. Cravatt

المصدر: ACS Central Science, Vol 7, Iss 4, Pp 613-623 (2021)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2374-7951Test

الوصول الحر: https://doaj.org/article/a04e120f3fbe486482f78386e90b336bTest

المؤلفون: Michael A. Serwetnyk, Vincent M. Crowley, Christopher M. Brackett, Trever R. Carter, Asif Elahi, Vamsi Krishna Kommalapati, Ahmed Chadli, Brian S. J. Blagg

مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Virology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, numerous oncogenic pathways, biologically active conformation, novel hsp90 inhibitors, negative breast cancer, various toxicities, structural modifications, structural features, simultaneously shut, nascent polypeptides, molecular chaperone, modulate triple, hsp90 inhibition, failed due, client substrates, branching moieties, alternative way, adverse events, 90 kilo

العلاقة: https://figshare.com/articles/journal_contribution/Enniatin_A_Analogues_as_Novel_Hsp90_Inhibitors_that_Modulate_Triple-Negative_Breast_Cancer/24582212Test

الإتاحة: https://doi.org/10.1021/acsmedchemlett.3c00423.s001Test
https://figshare.com/articles/journal_contribution/Enniatin_A_Analogues_as_Novel_Hsp90_Inhibitors_that_Modulate_Triple-Negative_Breast_Cancer/24582212Test

المؤلفون: Vincent M. Crowley (4419007), Marvin Thielert (10205010), Benjamin F. Cravatt (93774)

مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Infectious Diseases, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, covalent, Site-Specific Covalent Ligand Discovery, chemical proteomic methods, site-specific target engagement probes, ligandability, protein purification, Optimization Covalent ligands, sub -μM inhibitor, leverage electrophilic fragments, chemical probes, reactive electrophilic fragments, cysteine, ELISA-based assay formats, retinaldehyde reductase AKR 1B, Functionalized Scout Fragments

العلاقة: https://figshare.com/articles/journal_contribution/Functionalized_Scout_Fragments_for_Site-Specific_Covalent_Ligand_Discovery_and_Optimization/14373963Test

الإتاحة: https://doi.org/10.1021/acscentsci.0c01336.s001Test

المؤلفون: Xiaoyu Zhang (62901), Lena M. Luukkonen (10499083), Christie L. Eissler (10499086), Vincent M. Crowley (4419007), Yu Yamashita (1421008), Michael A. Schafroth (1771792), Shota Kikuchi (8968940), David S. Weinstein (2123176), Kent T. Symons (2252773), Brian E. Nordin (10499089), Joe L. Rodriguez (10499092), Thomas G. Wucherpfennig (10499095), Ludwig G. Bauer (10499098), Melissa M. Dix (1616689), Dean Stamos (1600186), Todd M. Kinsella (10499101), Gabriel M. Simon (131638), Kristen A. Baltgalvis (10499104), Benjamin F. Cravatt (93774)

مصطلحات موضوعية: Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Physiology, Pharmacology, Biotechnology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Electrophilic Proteolysis-Targeting., E 3-binding compounds, prostate cancer cells, Targeted Protein Degradation, ligand-induced protein degradation, E 3 ligase substrate adaptor, DCAF 11-directed electrophilic PROTACs, E 3 ligase, support ligand-induced protein degr., E 3 ligases, candidate electrophilic PROTACs, FBKP, electrophilic PROTACs act, DCAF 11

العلاقة: https://figshare.com/articles/journal_contribution/DCAF11_Supports_Targeted_Protein_Degradation_by_Electrophilic_Proteolysis-Targeting_Chimeras/14340274Test

الإتاحة: https://doi.org/10.1021/jacs.1c00990.s001Test

المؤلفون: Nada Eisa, Vincent M. Crowley, Asif Elahi, Vamsi K. Kommalapati, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli

المصدر: Cancer Research. 83:2272-2272

مصطلحات موضوعية: Cancer Research, Oncology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c022b97a59c124eb3ad9f0b1bfdb6a0bTest
https://doi.org/10.1158/1538-7445.am2023-2272Test

المؤلفون: Kristen A. Baltgalvis, Vincent M. Crowley, Michael A. Schafroth, Brian E. Nordin, Benjamin F. Cravatt, Christie L Eissler, Joe L Rodriguez, Shota Kikuchi, Xiaoyu Zhang, Thomas G Wucherpfennig, Todd Kinsella, Kent T Symons, Melissa M. Dix, David S. Weinstein, Dean Stamos, Gabriel M. Simon, Yu Yamashita, Ludwig Bauer, Lena M Luukkonen

المصدر: J Am Chem Soc

مصطلحات موضوعية: Male, Proteasome Endopeptidase Complex, Proteolysis, Protein degradation, 010402 general chemistry, 01 natural sciences, Biochemistry, Article, Catalysis, Chimera (genetics), Colloid and Surface Chemistry, Cell Line, Tumor, medicine, Humans, Receptor, medicine.diagnostic_test, biology, Ubiquitin, Chemistry, Prostatic Neoplasms, Ubiquitin-Protein Ligase Complexes, General Chemistry, 0104 chemical sciences, Ubiquitin ligase, Cell biology, Androgen receptor, Receptors, Androgen, Cell culture, Cancer cell, biology.protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9801b3a3bafd3e374259ca9ad1a1524Test
https://doi.org/10.1021/jacs.1c00990Test

المؤلفون: Laura L. Kiessling, Radu M. Suciu, Madeline E. Kavanagh, Yongfeng Tao, Benjamin F. Cravatt, Michael R. Lazear, Taka-Aki Ichu, Matthew Merrill Hayward, Vincent M. Crowley, Mikail E. Abbasov, Melissa M. Dix, Jordan Ho, Stephan M. Hacker, Christopher W. am Ende

المصدر: Nat Chem

مصطلحات موضوعية: Proteomics, Primary (chemistry), Innate immune system, Proteome, Chemistry, Lysine, General Chemical Engineering, General Chemistry, Computational biology, Ligands, Small molecule, complex mixtures, Article, Structure-Activity Relationship, HEK293 Cells, Electrophile, Human proteome project, Humans, bacteria

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f78bea59a5068219806c4dd51496f4dTest
https://europepmc.org/articles/PMC8952960Test/

المؤلفون: Luke L. Lairson, Sifei Yin, Dave Remillard, Vincent M. Crowley, Ekaterina V. Vinogradova, Gabriel M. Simon, Giulia Bianco, Megan M. Blewett, Yujia Wang, Radu M. Suciu, Michael R. Lazear, Melissa M. Dix, Stefano Forli, Yu Yamashita, Daniel C. Lazar, Maxim N. Shokhirev, Nhan Nguyen, John R. Teijaro, Benjamin F. Cravatt, Kenneth M. Lum, Esther K. Kemper, Emily N. Chin

مصطلحات موضوعية: 0303 health sciences, Chemistry, T cell, 010402 general chemistry, 01 natural sciences, Chemical synthesis, Small molecule, 0104 chemical sciences, 3. Good health, Cell biology, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Immune system, Covalent bond, 030220 oncology & carcinogenesis, Electrophile, Proteome, medicine, 030304 developmental biology, Cysteine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9699760a89f5fdcbd0e8820778a48f0aTest
https://doi.org/10.1101/808113Test

المؤلفون: Mikail E. Abbasov, Radu M. Suciu, Yongfeng Tao, Stephan M. Hacker, Matthew Merrill Hayward, Laura L. Kiessling, Michael R. Lazear, Benjamin F. Cravatt, Taka-Aki Ichu, Christopher W. am Ende, Vincent M. Crowley, Madeline E. Kavanagh, Jordan Ho, Melissa M. Dix

المصدر: Nature Chemistry. 13:1151-1151

مصطلحات موضوعية: Chemistry, Atlas (topology), General Chemical Engineering, Lysine, Proteome, General Chemistry, Computational biology, Proteomics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::2f15cfb76de36ce762573e3d259b3beeTest
https://doi.org/10.1038/s41557-021-00823-xTest