Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk
| العنوان: | Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk |
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| المؤلفون: | Núria Malats, Paul Brennan, Veronica Wendy Setiawan, Yaohua Yang, Jirong Long, Thilo Hackert, Xiaoliang Wang, Charles Kooperberg, Michael Goggins, Manal M. Hassan, I-Min Lee, Elizabeth A. Holly, Graham G. Giles, Roger L. Milne, Brian M. Wolpin, Miquel Porta, Verena Katske, Sonja I. Berndt, Herbert Yu, Laura E. Beane Freeman, Kari G. Rabe, Jean Wactawski-Wende, Robert N. Hoover, Stephen J. Chanock, Paige M. Bracci, Fei Ye, Ann L. Oberg, Wei Zheng, Anne Zeleniuch-Jacquotte, Lauren K. Brais, Samuel O. Antwi, Pilar Amiano, Nicolas Wentzensen, J. Michael Gaziano, Dalia Ghoneim, Jingjing Zhu, Rachel E. Neale, Charles S. Fuchs, Nathaniel Rothman, Ghislaine Scelo, Philip C Haycock, Alison P. Klein, Neil Murphy, Harvey A. Risch, Nikhil K. Khankari, Lynne R. Wilkens, Laufey T. Amundadottir, Peter Kraft, Mengmeng Du, Eric J. Jacobs, Federico Canzian, Ian M. Thompson, Alan A. Arslan, Howard D. Sesso, Emily White, Eric J. Duell, Gloria M. Petersen, Phyllis J. Goodman, Stolzenberg-Solomon R, Xiao-Ou Shu, Harvey J. Murff, Priya Duggal, Kathy J. Helzlsouer, Steven Gallinger, Demetrius Albanes, Bas Bueno-de-Mesquita, William R. Bamlet, Kai Yu, Gabriella Andreotti, Lang Wu, Peter T. Campbell, Robert C. Kurtz, Debra T. Silverman, Ana Babic, Julie E. Buring, Kala Visvanathan, Loic Le Marchand |
| المصدر: | Cancer Epidemiol Biomarkers Prev |
| بيانات النشر: | American Association for Cancer Research (AACR), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Epidemiology, Linoleic acid, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Fatty Acids, Omega-6, Internal medicine, Pancreatic cancer, Mendelian randomization, Humans, Medicine, Aged, chemistry.chemical_classification, business.industry, Mendelian Randomization Analysis, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Pancreatic Neoplasms, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Cohort, Female, business, Polyunsaturated fatty acid |
| الوصف: | Background: Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome. Methods: We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case–Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data. Results: Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95% confidence interval (CI) = 0.98–1.02; arachidonic acid OR = 1.00, 95% CI = 0.99–1.01; and dihomo-gamma-linolenic acid OR = 0.95, 95% CI = 0.87–1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex. Conclusions: Our results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk. Impact: These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer. |
| تدمد: | 1538-7755 1055-9965 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2886118b20dfa9850ac2f125ad36ec5Test https://doi.org/10.1158/1055-9965.epi-20-0651Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a2886118b20dfa9850ac2f125ad36ec5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387755 10559965 |
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