دورية أكاديمية
The Fractional exhaled Nitric Oxide (FeNO)- test as add-on test in the diagnostic work-up of asthma:a study protocol
| العنوان: | The Fractional exhaled Nitric Oxide (FeNO)- test as add-on test in the diagnostic work-up of asthma:a study protocol |
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| المؤلفون: | Kaya, T., Braunstahl, G. J., Veen, J. C.C.M.(Johannes) in ’t, Kappen, J. H., Valk, J. P.M.(Hanna) van der |
| المصدر: | Kaya , T , Braunstahl , G J , Veen , J C C M I , Kappen , J H & Valk , J P M V D 2024 , ' The Fractional exhaled Nitric Oxide (FeNO)- test as add-on test in the diagnostic work-up of asthma : a study protocol ' , BMC Pulmonary Medicine , vol. 24 , no. 1 , 178 . https://doi.org/10.1186/s12890-024-02990-2Test |
| سنة النشر: | 2024 |
| الوصف: | Background: Asthma is a common disease characterized by chronic inflammation of the lower airways, bronchial hyperactivity, and (reversible) airway obstruction. The Global Initiative of Asthma Guideline recommends a flowchart to diagnose asthma with first-step spirometry with reversibility and a bronchial challenge test (BPT) with histamine or methacholine as a second step [1]. The BPT is considered burdensome, time-consuming for patients and staff, can cause side effects, and is expensive. In addition, this test strongly encumbers lung function capacity. Elevated Nitric Oxide (NO) is associated with airway eosinophilic inflammation in asthma patients and can be measured in exhaled air with the Fractional exhaled (Fe) NO-test. This low-burden FeNO-test could be used as an ‘add-on’ test in asthma diagnostics [2, 3]. Methods and analysis: This multi-center prospective study (Trial number: NCT06230458) compares the ‘standard asthma diagnostic work-up’ (spirometry with reversibility and BPT) to the ‘new asthma diagnostics work-up’ (FeNO-test as an intermediate step between the spirometry with reversibility and the BPT), intending to determine the impact of the FeNO-based strategy, in terms of the number of avoided BPTs, cost-effectiveness and reduced burden to the patient and health care. The cost reduction of incorporating the FeNO-test in the new diagnostic algorithm will be established by the number of theoretically avoided BPT. The decrease in burden will be studied by calculating differences in the Visual Analogue Scale (VAS) -score and Asthma Quality of Life Questionnaire (AQLQ) -score after the BPT and FeNO-test with an independent T-test. The accuracy of the FeNO-test will be calculated by comparing the FeNO-test outcomes to the (gold standard) BPTs outcomes in terms of sensitivity and specificity. The intention is to include 171 patients. Ethics and dissemination: The local medical ethics committee approved the proposed study and is considered a low-burden and risk-low study. The local medical ethics ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://pure.eur.nl/en/publications/f04fc7bd-79c7-4d1b-b885-736f554c8e62Test |
| DOI: | 10.1186/s12890-024-02990-2 |
| الإتاحة: | https://doi.org/10.1186/s12890-024-02990-2Test https://pure.eur.nl/en/publications/f04fc7bd-79c7-4d1b-b885-736f554c8e62Test https://pure.eur.nl/ws/files/144434483/The_Fractional_exhaled_Nitric_Oxide_FeNO_-_test_as_add-on_test_in_the_diagnostic_work-up_of_asthma.pdfTest http://www.scopus.com/inward/record.url?scp=85190418535&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.31AB5DDE |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12890-024-02990-2 |
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