المؤلفون: Dumesnil, Calvin, Vanharanta, Lauri, Prasanna, Xavier, Omrane, Mohyeddine, Carpentier, Maxime, Bhapkar, Apoorva, Enkavi, Giray, Salo, Veijo, Vattulainen, Ilpo, Ikonen, Elina, Thiam, Abdou Rachid

المساهمون: Microfluidique, Émulsion et Biologie, Laboratoire de physique de l'ENS - ENS Paris (LPENS), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Département de Physique de l'ENS-PSL, Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL), Faculty of Medecine Helsinki, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Department of Physics Helsinki, Falculty of Science Helsinki, Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, European Molecular Biology Laboratory (EMBL), ANR-21-CE11-0032-02-LIPRODYN, Agence Nationale de la Recherche, ANR-18-CE11-0012,MOBIL,Liaison spécifique de protéines aux gouttelettes lipidiques(2018), ANR-21-CE11-0032,LIPRODYN,Dynamique des lipides et protéines dans l'assemblage des gouttelettes lipidiques(2021)

المصدر: ISSN: 2041-1723.

مصطلحات موضوعية: Cholesterol ester, Lipid droplet biogenesis, Supercooling, Smectic liquid crystals, Nucleation, Cholesterol, Triacylglycerol, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/36807572; hal-04003444; https://hal.sorbonne-universite.fr/hal-04003444Test; https://hal.sorbonne-universite.fr/hal-04003444/documentTest; https://hal.sorbonne-universite.fr/hal-04003444/file/MS-rev-20230126.pdfTest; PUBMED: 36807572

الإتاحة: https://doi.org/10.1038/s41467-023-36375-6Test
https://hal.sorbonne-universite.fr/hal-04003444Test
https://hal.sorbonne-universite.fr/hal-04003444/documentTest
https://hal.sorbonne-universite.fr/hal-04003444/file/MS-rev-20230126.pdfTest

المؤلفون: Takahashi, Kohta, Kanerva, Kristiina, Vanharanta, Lauri, Almeida-Souza, Leonardo, Lietha, Daniel, Olkkonen, Vesa M., Ikonen, Elina

المساهمون: Academy of Finland, Fondation Leducq, Jane and Aatos Erkko Foundation, Magnus Ehrnrooth Foundation, Finnish Foundation for Cardiovascular Research, Helsinki Institute of Life Science, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Takahashi, Kohta, Kanerva, Kristiina, Vanharanta, Lauri, Almeida-Souza, Leonardo, Lietha, Daniel, Olkkonen, Vesa M., Ikonen, Elina

مصطلحات موضوعية: Cholesterol trafficking, Focal adhesion kinase, Oxysterol-binding protein-related protein, Phosphoinositides, Recycling

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099318-B-I00; Publisher's version; https://doi.org/10.15252/embj.2020106871Test; Sí; EMBO Journal e106871 (2021); http://hdl.handle.net/10261/243571Test; http://dx.doi.org/10.13039/501100001674Test; http://dx.doi.org/10.13039/501100002341Test; http://dx.doi.org/10.13039/501100011033Test; http://dx.doi.org/10.13039/501100000780Test

الإتاحة: https://doi.org/10.15252/embj.2020106871Test
https://doi.org/10.13039/501100001674Test
https://doi.org/10.13039/501100002341Test
https://doi.org/10.13039/501100011033Test
https://doi.org/10.13039/501100000780Test
http://hdl.handle.net/10261/243571Test

المؤلفون: Takahashi, Kohta, Kanerva, Kristiina, Vanharanta, Lauri, Almeida-Souza, Leonardo, Lietha, Daniel, Olkkonen, Vesa M., Ikonen, Elina

المساهمون: STEMM - Stem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Department of Anatomy, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Faculty of Biological and Environmental Sciences, Lipid Trafficking Lab

مصطلحات موضوعية: cholesterol trafficking, focal adhesion kinase, oxysterol-binding protein-related protein, phosphoinositides, recycling, LOW-DENSITY-LIPOPROTEIN, INTEGRIN ACTIVATION, PLASMA-MEMBRANE, HEARING-LOSS, TRAFFICKING, NPC1, PROTEIN, OSBPL2, COMPLEXES, TRIGGERS, 1182 Biochemistry, cell and molecular biology

وصف الملف: application/pdf

العلاقة: We thank Anna Uro for excellent technical assistance, Shiqian Li for help in establishing degron-ORP2 cells, Yosuke Senju for help in liposome assays, Young Ah Kim for BODIPY-cholesteryl linoleate, Mikko Liljestrom for help with image analysis, and Biocenter Finland and HiLIFE for infrastructure support (BioImaging platform, Flow cytometry unit). This study was supported by the Academy of Finland (grants 307415 and 324929 to E.I., 322647 to V.M.O.), Sigrid Juselius Foundation (E.I., V.M.O., L. A.-S.), Fondation Leducq (grant 19CVD04) (E.I.), Jane and Aatos Erkko Foundation (E.I.), Magnus Ehrnrooth Foundation (K.T., V.M.O.), and the Finnish Foundation for Cardiovascular Research (V.M.O.). L.-A.S. acknowledges support from Helsinki Institute of Life Science (HiLIFE, start-up grant) and D.L. from the Ministry of Science, Innovation and Universities for the Spanish State Research Agency Retos Grant RTI2018-099318-B-I00, cofounded by the European Regional Development Fund (FEDER).; Takahashi , K , Kanerva , K , Vanharanta , L , Almeida-Souza , L , Lietha , D , Olkkonen , V M & Ikonen , E 2021 , ' ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P-2 exchange ' , EMBO Journal , vol. 40 , no. 14 , 106871 . https://doi.org/10.15252/embj.2020106871Test; ORCID: /0000-0001-8382-1135/work/98322789; ORCID: /0000-0003-1680-9448/work/98323740; ORCID: /0000-0002-7169-1238/work/98326026; 113bf19a-c264-4041-aa29-928bc97f670a; http://hdl.handle.net/10138/335038Test; 000661099300001

الإتاحة: http://hdl.handle.net/10138/335038Test

المؤلفون: Vanharanta, Lauri, Peränen, Johan, Pfisterer, Simon G., Enkavi, Giray, Vattulainen, Ilpo, Ikonen, Elina

المساهمون: Tampere University, Physics, Research group: Biological Physics and Soft Matter

مصطلحات موضوعية: 114 Physical sciences, 217 Medical engineering

وصف الملف: fulltext

العلاقة: 21; https://trepo.tuni.fi/handle/10024/127392Test; URN:NBN:fi:tuni-202008126439

الإتاحة: https://doi.org/10.1111/tra.12727Test
https://trepo.tuni.fi/handle/10024/127392Test

المؤلفون: Gungor, Burcin, Vanharanta, Lauri, Hölttä-Vuori, Maarit, Pirhonen, Juho, Petersen, Nikolaj H. T., Gramolelli, Silvia, Ojala, Päivi M., Kirkegaard, Thomas, Ikonen, Elina

المساهمون: Department of Anatomy, Faculty of Medicine, University of Helsinki, Medicum, STEMM - Stem Cells and Metabolism Research Program, University Management, CAN-PRO - Translational Cancer Medicine Program, Research Programs Unit, Lipid Trafficking Lab

مصطلحات موضوعية: Cholesterol metabolism, Liver X receptor, Heat shock protein, Human macrophages, Transcriptional regulation, HEAT-SHOCK-PROTEINS, HEAT-SHOCK-PROTEIN-70, ATHEROSCLEROSIS, MECHANISMS, TRANSPORT, MEMBRANE, EFFLUX, HSP90, 3121 General medicine, internal medicine and other clinical medicine, 3111 Biomedicine

وصف الملف: application/pdf

العلاقة: We thank Anna Uro and Pipsa Kaipainen for technical assistance and HiLIFE infrastructures (Biomedicum Imaging Unit, Zebrafish Unit, Functional Genomics Unit). This study was financially supported by the University of Helsinki, Academy of Finland (grants 282192, 284667, 307415 to E.I.; 307366 to P.M.O. and 309544 to S.G.), Orphazyme A/S, and Sigrid Juselius Foundation (grant to E.I.).; Gungor , B , Vanharanta , L , Hölttä-Vuori , M , Pirhonen , J , Petersen , N H T , Gramolelli , S , Ojala , P M , Kirkegaard , T & Ikonen , E 2019 , ' HSP70 induces liver X receptor pathway activation and cholesterol reduction in vitro and in vivo ' , Molecular metabolism , vol. 28 , pp. 135-143 . https://doi.org/10.1016/j.molmet.2019.07.005Test; ORCID: /0000-0002-0488-4486/work/63999423; ORCID: /0000-0001-8382-1135/work/63999803; 4a5be61c-1c01-4eb6-b390-63e7f230370a; http://hdl.handle.net/10138/306649Test; 000487684000012

الإتاحة: http://hdl.handle.net/10138/306649Test

المؤلفون: Takahashi, Kohta, Kanerva, Kristiina, Vanharanta, Lauri, Almeida‐Souza, Leonardo, Lietha, Daniel, Olkkonen, Vesa M, Ikonen, Elina

المصدر: EMBO Journal; Jul2021, Vol. 40 Issue 14, p1-20, 20p

مصطلحات موضوعية: LDL cholesterol, HYDROXYCHOLESTEROLS, FOCAL adhesion kinase, PROTEOLYSIS, CHOLESTEROL, BILAYER lipid membranes, CELL motility, CELL adhesion

المؤلفون: Kristiina Kanerva, Lauri Vanharanta, Leonardo Almeida-Souza, Kohta Takahashi, Daniel Lietha, Elina Ikonen, Vesa M. Olkkonen

المساهمون: Academy of Finland, Fondation Leducq, Jane and Aatos Erkko Foundation, Magnus Ehrnrooth Foundation, Finnish Foundation for Cardiovascular Research, Helsinki Institute of Life Science, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Takahashi, Kohta [0000-0001-9499-9035], Kanerva, Kristiina [0000-0003-1680-9448], Vanharanta, Lauri [0000-0002-7902-0009], Almeida-Souza, Leonardo [0000-0002-7169-1238], Lietha, Daniel [0000-0002-6133-6486], Olkkonen, Vesa M. [0000-0001-5553-7997], Ikonen, Elina [0000-0001-8382-1135], STEMM - Stem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Department of Anatomy, Helsinki Institute of Life Science HiLIFE, Institute of Biotechnology, Faculty of Biological and Environmental Sciences, Lipid Trafficking Lab, Takahashi, Kohta, Kanerva, Kristiina, Vanharanta, Lauri, Almeida-Souza, Leonardo, Lietha, Daniel, Olkkonen, Vesa M., Ikonen, Elina

المصدر: Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: Endosome, Phosphoinositides, LOW-DENSITY-LIPOPROTEIN, PROTEIN, Endogeny, Biology, recycling, General Biochemistry, Genetics and Molecular Biology, Cholesterol trafficking, Focal adhesion, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, TRAFFICKING, Recycling, Lipid bilayer, Cell adhesion, Molecular Biology, 030304 developmental biology, 0303 health sciences, General Immunology and Microbiology, Cholesterol, INTEGRIN ACTIVATION, General Neuroscience, HEARING-LOSS, focal adhesion kinase, Focal adhesion kinase, Cell migration, phosphoinositides, TRIGGERS, 3. Good health, Cell biology, oxysterol-binding protein-related protein, NPC1, Oxysterol-binding protein-related protein, chemistry, cholesterol trafficking, PLASMA-MEMBRANE, OSBPL2, 1182 Biochemistry, cell and molecular biology, lipids (amino acids, peptides, and proteins), COMPLEXES, 030217 neurology & neurosurgery, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1c9029a46a82836885a511d282d41cTest
http://hdl.handle.net/10261/243571Test