دورية أكاديمية
Dual association of a TRKA polymorphism with schizophrenia
العنوان: | Dual association of a TRKA polymorphism with schizophrenia |
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المؤلفون: | Van Schijndel, J.E., Van Zweeden, M., Mortensen, P.B., Mors, O., Borgium, A.D., Del-Favero, J., Norrback, K.F., Adolfsson, R., De Hert, M., Claes, S., Cichon, S., Rietschel, M., Van Loo, K.M.J., Nöthen, M.M., Kallunki, P., Pedersen, J.T., Martens, G.J.M., Djurovic, S., Andreassen, O.A., Hansen, T., Werge, T., Nyegaard, M., Sorensen, K.M., Nordentoft, M. |
المصدر: | Psychiatric genetics 21, 125 - 131 (2011). doi:10.1097/YPG.0b013e3283437194 |
بيانات النشر: | Lippincott Williams & Wilkins |
سنة النشر: | 2011 |
المجموعة: | Forschungszentrum Jülich: JuSER (Juelich Shared Electronic Resources) |
مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Adult, Base Sequence, Case-Control Studies, DNA Primers, Europe, Female, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Receptor, trkA: genetics, Schizophrenia: genetics, United States, trkA, case-control study, meta-analysis, neurotrophic tyrosine kinase receptor 1, protective factor, risk factor |
جغرافية الموضوع: | DE |
الوصف: | An interaction between predisposing genes and environmental stressors is thought to underlie the neurodevelopmental disorder schizophrenia. In a targeted gene screening, we previously found that the minor allele of the single nucleotide polymorphism (SNP) rs6336 in the neurotrophic tyrosine kinase receptor 1 (NTRK1/TRKA) gene is associated with schizophrenia as a risk factor.We genotyped the TRKA SNP in a total of eight independent Caucasian schizophrenia case-control groups.Remarkably, although in five of the groups a higher frequency of the risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor.An intriguing possibility is that this dual character of the TRKA SNP is caused by its interaction with endophenotypic and/or epistatic factors. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000289770400002; info:eu-repo/semantics/altIdentifier/issn/0955-8829; info:eu-repo/semantics/altIdentifier/pmid/pmid:21317683; https://juser.fz-juelich.de/record/16144Test; https://juser.fz-juelich.de/search?p=id:%22PreJuSER-16144%22Test |
الإتاحة: | https://doi.org/10.1097/YPG.0b013e3283437194Test https://juser.fz-juelich.de/record/16144Test https://juser.fz-juelich.de/search?p=id:%22PreJuSER-16144%22Test |
حقوق: | info:eu-repo/semantics/closedAccess |
رقم الانضمام: | edsbas.F0B98126 |
قاعدة البيانات: | BASE |
الوصف غير متاح. |