المؤلفون: Masureel, Matthieu, Zou, Yaozhong, Picard, Louis-Philippe, van der Westhuizen, Emma, Mahoney, Jacob P, Rodrigues, João PGLM, Mildorf, Thomas J, Dror, Ron O, Shaw, David E, Bouvier, Michel, Pardon, Els, Steyaert, Jan, Sunahara, Roger K, Weis, William I, Zhang, Cheng, Kobilka, Brian K

المصدر: Nature Chemical Biology. 14(11)

مصطلحات موضوعية: Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Sciences, Lung, Respiratory, Adrenergic beta-2 Receptor Agonists, Animals, Antibodies, Asthma, Binding Sites, Computer Simulation, Crystallography, X-Ray, GTP-Binding Proteins, Humans, Hydrogen Bonding, Ligands, Lipids, Mutagenesis, Protein Binding, Protein Conformation, Pulmonary Disease, Chronic Obstructive, Receptors, Adrenergic, beta-2, Salmeterol Xinafoate, Signal Transduction, beta-Arrestins, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medicinal and biomolecular chemistry

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/18x9z7xgTest

المؤلفون: Vuckovic, Ziva, Wang, Jinan, Pham, Vi, Mobbs, Jesse I., Belousoff, Matthew J., Bhattarai, Apurba, Burger, Wessel A.C., Thompson, Geoff, Yeasmin, Mahmuda, Nawaratne, Vindhya, Leach, Katie, van der Westhuizen, Emma T., Khajehali, Elham, Liang, Yi-Lynn, Glukhova, Alisa, Wootten, Denise, Lindsley, Craig W., Tobin, Andrew, Sexton, Patrick, Danev, Radostin, Valant, Celine, Miao, Yinglong, Christopoulos, Arthur, Thal, David M.

وصف الملف: application/pdf

العلاقة: Vuckovic, Ziva et al. “Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.” eLife vol. 12 e83477. 30 May. 2023, doi:10.7554/eLife.83477; https://hdl.handle.net/1808/34328Test; orcid:0000-0001-9165-8526; orcid:0000-0002-1807-3123; orcid:0000-0003-4442-3294; orcid:0000-0002-0325-2524; PMC10229135

الإتاحة: https://doi.org/10.7554/eLife.83477Test
https://hdl.handle.net/1808/34328Test

المؤلفون: van der Westhuizen, Emma T.¹ (AUTHOR) emma.vanderwesthuizen@monash.edu

المصدر: British Journal of Pharmacology. Jul2024, Vol. 181 Issue 14, p2158-2181. 24p.

مصطلحات موضوعية: *SINGLE nucleotide polymorphisms, *MISSENSE mutation, *GENETIC mutation, *INTRACELLULAR space, *AUTISM, *G protein coupled receptors

المؤلفون: Nguyen, Huong T. M.^1,2 (AUTHOR), van der Westhuizen, Emma T.¹ (AUTHOR), Langmead, Christopher J.^1,3,4 (AUTHOR), Tobin, Andrew B.⁵ (AUTHOR), Sexton, Patrick M.^1,4 (AUTHOR), Christopoulos, Arthur^1,3,4 (AUTHOR), Valant, Celine^1,3 (AUTHOR) celine.valant@monash.edu

المصدر: British Journal of Pharmacology. Jul2024, Vol. 181 Issue 14, p2114-2142. 29p.

مصطلحات موضوعية: *GABA receptors, *MUSCARINIC acetylcholine receptors, *MUSCARINIC receptors, *G protein coupled receptors, *DRUG receptors, *ALZHEIMER'S disease, *DRUG discovery

المؤلفون: Vuckovic, Ziva, Gentry, Patrick R., Berizzi, Alice E., Hirata, Kunio, Varghese, Swapna, Thompson, Geoff, van der Westhuizen, Emma T., Burger, Wessel A. C., Rahmani, Raphaël, Valant, Celine, Langmead, Christopher J., Lindsley, Craig W., Baell, Jonathan B., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur, Thal, David M.

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 2019 Dec . 116(51), 26001-26007.

الوصول الحر: https://www.jstor.org/stable/26863948Test

المؤلفون: van der Westhuizen, Emma T., Choy, K. H. Christopher, Valant, Celine, McKenzie-Nickson, Simon, Bradley, Sophie J., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur

المصدر: Frontiers in Pharmacology ; volume 11 ; ISSN 1663-9812

الإتاحة: https://doi.org/10.3389/fphar.2020.606656Test

المؤلفون: Benredjem, Besma, Gallion, Jonathan, Pelletier, Dennis, Dallaire, Paul, Charbonneau, Johanie, Cawkill, Darren, Nagi, Karim, Gosink, Mark, Lukasheva, Viktoryia, Jenkinson, Stephen, Ren, Yong, Somps, Christopher, Murat, Brigitte, Van Der Westhuizen, Emma, Le Gouill, Christian, Lichtarge, Olivier, Schmidt, Anne, Bouvier, Michel, Pineyro, Graciela

المصدر: Nature Communications ; volume 11, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41467-020-15945-yTest
https://www.nature.com/articles/s41467-020-15945-y.pdfTest
https://www.nature.com/articles/s41467-020-15945-yTest

المؤلفون: Nguyen, Huong T. M., van der Westhuizen, Emma T., Langmead, Christopher J., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur, Valant, Celine

العلاقة: Nguyen, H. T. M., van der Westhuizen, E. T., Langmead, C. J., Tobin, A. B. , Sexton, P. M., Christopoulos, A. and Valant, C. (2023) Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits. British Journal of Pharmacology , (doi:10.1111/bph.15982 ) (PMID:36355830) (Early Online Publication)

الإتاحة: https://doi.org/10.1111/bph.15982Test
https://eprints.gla.ac.uk/286537Test/

المؤلفون: van der Westhuizen, Emma T.

المساهمون: Wellcome Trust

المصدر: British Journal of Pharmacology ; ISSN 0007-1188 1476-5381

الإتاحة: https://doi.org/10.1111/bph.16057Test

المؤلفون: Jörg, Manuela, van der Westhuizen, Emma T., Lu, Yao, Christopher Choy, K.H., Shackleford, David M., Khajehali, Elham, Tobin, Andrew B., Thal, David M., Capuano, Ben, Christopoulos, Arthur, Valant, Celine, Scammells, Peter J.

المصدر: European Journal of Medicinal Chemistry ; volume 258, page 115588 ; ISSN 0223-5234

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Pharmacology, General Medicine

الإتاحة: https://doi.org/10.1016/j.ejmech.2023.115588Test
https://api.elsevier.com/content/article/PII:S0223523423005548?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0223523423005548?httpAccept=text/plainTest