المؤلفون: Gonen, Nitzan, Eozenou, Caroline, Mitter, Richard, Elzaiat, Maëva, Stévant, Isabelle, Aviram, Rona, Bernardo, Andreia Sofia, Chervova, Almira, Wankanit, Somboon, Frachon, Emmanuel, Commere, Pierre-Henri, Brailly-Tabard, Sylvie, Valon, Léo, Barrio Cano, Laura, Levayer, Romain, Mazen, Inas, Gobaa, Samy, Smith, James C., McElreavey, Kenneth, Lovell-Badge, Robin, Bashamboo, Anu

المصدر: Science Advances 9(1)

العلاقة: info:eu-repo/grantAgreement/ANR//ANR-20-CE14-0007/; info:eu-repo/grantAgreement/EC/HE/101039928/; info:eu-repo/grantAgreement/WT//FC001107/; info:eu-repo/grantAgreement/ANR//ANR-19-CE14-0022/; info:eu-repo/grantAgreement/ANR//ANR-17-CE14-0038/; info:eu-repo/grantAgreement/ANR//ANR-19-CE14-0012/; https://zenodo.org/record/7546865Test; https://doi.org/10.1126/sciadv.abn9793Test; oai:zenodo.org:7546865

الإتاحة: https://doi.org/10.1126/sciadv.abn9793Test
https://zenodo.org/record/7546865Test

المؤلفون: Villars, Alexis, Letort, Gaëlle, Valon, Léo, Levayer, Romain

المساهمون: Biologie du Développement et Cellules souches (CNRS UMR3738), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Ecole Doctorale Complexité du Vivant (ED515), Sorbonne Université (SU), A.V. was supported by a PhD grant from the doctoral school ‘Complexité du Vivant’ Sorbonne Université and from an extension grant of the Ligue Contre le Cancer. Work in the R.L. lab is supported by the Institut Pasteur (G5 starting package), a European Research Council starting grant (CoSpaDD, Competition for Space in Development and Disease, grant number 758457), the Agence Nationale de la Recherche (CoECECa, Coordination of Epithelial Cell Extrusion by Caspases) and the Centre National de la Recherche Scientifique (UMR 3738). We also thank Danielle Casteran and her family for their generous donation, which helped to finalise this project. Open Access funding provided by the European Research Council. Deposited in PMC for immediate release., We acknowledge the Image Analysis Hub of the Institut Pasteur for discussions and advice for this work. We thank Jean-Yves Tinevez, Kevin Yamauchi and Raphaël Etournay for critical reading of the manuscript. We also thank Raphaël Etournay for sharing the pupal wing movie and Nic Tapon for providing the original and segmentation of the pupal abdomen movies. We acknowledge the help of the HPC Core Facility of the Institut Pasteur for this work., ANR-22-CE13-0002,CoECECa,Vers une caractérisation exhaustive de la coordination de l'extrusion epithéliales par les caspases(2022), European Project: 758457,H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),ERC-2017-STG,CoSpaDD(2018)

المصدر: ISSN: 0950-1991.

مصطلحات موضوعية: Deep-learning, convolutional neural network, epithelia, live imaging, extrusion, cell division, SOPs, Drosophila, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37283069; info:eu-repo/grantAgreement//758457/EU/Competition for Space in Development and Diseases/CoSpaDD; pasteur-04244427; https://pasteur.hal.science/pasteur-04244427Test; https://pasteur.hal.science/pasteur-04244427/documentTest; https://pasteur.hal.science/pasteur-04244427/file/Villars%26LetortFused.pdfTest; PUBMED: 37283069; PUBMEDCENTRAL: PMC10323232

الإتاحة: https://doi.org/10.1242/dev.201747Test
https://pasteur.hal.science/pasteur-04244427Test
https://pasteur.hal.science/pasteur-04244427/documentTest
https://pasteur.hal.science/pasteur-04244427/file/Villars%26LetortFused.pdfTest

المؤلفون: Valon, Léo

مرشدي الرسالة: Paris, Ecole normale supérieure, Dahan, Maxime

مصطلحات موضوعية: Optogénétique, Migration cellulaire, RhoGTPases, Perturbation spatiotemporelle, Microscopie TIRF, Réaction diffusion, Optogenetics, Cell migration, Spatiotemporal perturbation, TIRF microscopy, Diffusion reaction, 530

الإتاحة: http://www.theses.fr/2014ENSU0008/documentTest

المؤلفون: Kelkar, Manasi, Bohec, Pierre, Smith, Matthew B, Sreenivasan, Varun, Lisica, Ana, Valon, Léo, Ferber, Emma, Baum, Buzz, Salbreux, Guillaume, Charras, Guillaume

المصدر: Proceedings of the National Academy of Sciences , 119 (26) , Article e2121868119. (2022)

مصطلحات موضوعية: RhoA, cell cortex, mechanics, optogenetics, spindle orientation, Actomyosin, Computer Simulation, Cytoplasm, Microtubules, Spindle Apparatus, Stress, Mechanical, rhoA GTP-Binding Protein

وصف الملف: application/pdf

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10152872/1/pnas.2121868119.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10152872Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10152872/1/pnas.2121868119.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10152872Test/

المؤلفون: Valon, Léo, Davidović, Anđela, Levillayer, Florence, Villars, Alexis, Chouly, Mathilde, Cerqueira-Campos, Fabiana, Levayer, Romain

المساهمون: Cellules Souches et Développement / Stem Cells and Development, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Département de Biologie Computationnelle - Department of Computational Biology, Collège Doctoral, Sorbonne Université (SU), L.V. is supported by a postdoctoral grant “Aide au Retour en France” from the FRM (Fondation pour la Recherche Médicale, ARF20170938651) and a Marie Sklodowska-Curie postdoctoral fellowship (MechDeath, 789573), and work in R.L.’s lab is supported by the Institut Pasteur (G5 starting package), the ERC starting grant CoSpaDD (Competition for Space in Development and Disease, grant number 758457), and the Cercle FSER, and the CNRS (UMR 3738)., We thank members of R.L.’s lab for critical reading of the manuscript, especially Alexis Matamoro-Vidal for suggestions on the manuscript organization. We would like to thank Jakub Voznica for initiating observations of miniCic in the pupal abdomen during his internship and Anne Loap for her contribution to tissue segmentation and caspase dynamics analysis during her internship. We also thank Virgile Andreani for help in improving simulations, statistical analysis of the data, and some mathematical expressions. We are grateful for the image analysis center of Pasteur Institute and Jean-Yves Tinevez for converting the local-projection program to Fiji. We are also grateful to Magali Suzanne, Yohanns Bellaïche, Shigeo Hayashi, Jared Toettcher, the Bloomington Drosophila Stock Center, the Drosophila Genetic Resource Center, and the Vienna Drosophila Resource Center for sharing stocks and reagents. We also thank B. Aigouy for the Packing Analyser software and the J. Ellenberg group for MyPic autofocus macro., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), European Project: 758457,H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),ERC-2017-STG,CoSpaDD(2018)

المصدر: ISSN: 1534-5807 ; Developmental Cell ; https://hal.sorbonne-universite.fr/hal-03250153Test ; Developmental Cell, 2021, ⟨10.1016/j.devcel.2021.05.006⟩.

مصطلحات موضوعية: apoptosis, caspase dynamics, cell extrusion, epithelium, optogenetics, self-organization, single-cell live imaging, Drosophila, ERK, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34081909; info:eu-repo/grantAgreement//758457/EU/Competition for Space in Development and Diseases/CoSpaDD; hal-03250153; https://hal.sorbonne-universite.fr/hal-03250153Test; https://hal.sorbonne-universite.fr/hal-03250153v2/documentTest; https://hal.sorbonne-universite.fr/hal-03250153v2/file/1-s2.0-S1534580721004354-main.pdfTest; PUBMED: 34081909

الإتاحة: https://doi.org/10.1016/j.devcel.2021.05.006Test
https://hal.sorbonne-universite.fr/hal-03250153Test
https://hal.sorbonne-universite.fr/hal-03250153v2/documentTest
https://hal.sorbonne-universite.fr/hal-03250153v2/file/1-s2.0-S1534580721004354-main.pdfTest

المؤلفون: Herbert, Sébastien, Valon, Léo, Mancini, Laure, Dray, Nicolas, Caldarelli, Paolo, Gros, Jérôme, Esposito, Elric, Shorte, Spencer, L, Bally-Cuif, Laure, Aulner, Nathalie, Levayer, Romain, Tinevez, Jean-Yves

المساهمون: Hub d'analyse d'images - Image Analysis Hub (Platform) (IAH), Institut Pasteur Paris (IP), Mort cellulaire et homéostasie des épithéliums / Cell death and epithelial homeostasis, Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Neurogénétique du Poisson zébré / Zebrafish Neurogenetics, Collège Doctoral, Sorbonne Université (SU), Régulation Dynamique de la Morphogénèse - Dynamic Regulation of Morphogenesis, BioImagerie Photonique – Photonic BioImaging (UTechS PBI), This work was supported by the Labex REVIVE (Investissement d’Avenir, ANR-10-LABX-73), France BioImaging (Investissement d’Avenir, ANR-10–INSB–04) and the Région Île-de-France in the framework of DIM ELICIT. Work in the R. L. laboratory is supported by the Institut Pasteur (G5 starting package), a ERC starting grant (CoSpaDD, #758457), the “Cercle FSER” and the CNRS (UMR 3738). L. V. is supported by a Post-doctoral grant “Aide au 224 Retour en France” from the Fondation pour la Recherche Médicale (ARF20170938651) and a Marie Sklodowska-Curie postdoctoral fellowship (MechDeath, 789573). Work in the J. G. laboratory was supported by the European Research Council under the European Union’s Seventh Framework Program (FP7/2007-2013) / ERC Grant Agreement no. 337635. P. C. is sponsored by the Institut Pasteur and the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska Curie (665807). Work in the L. B-C. laboratory was supported by the Ligue Nationale Contre le Cancer and the European Research Council (AdG 322936). L. M. was recipient of a PhD student fellowship from the Fondation pour la Recherche Médicale., ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), European Project: 758457,H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC),ERC-2017-STG,CoSpaDD(2018), European Project: 789573,FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013),H2020-MSCA-IF-2017,MechDeath(2019), European Project: 337635,EC:FP7:ERC,ERC-2013-StG,LIMBCELLDYNAMICS(2014), European Project: 665807,H2020,H2020-MSCA-COFUND-2014,PASTEURDOC(2015), European Project: 322936,EC:FP7:ERC,ERC-2012-ADG_20120314,SYSTEMATICS(2013)

المصدر: ISSN: 1741-7007.

مصطلحات موضوعية: 3D imaging, Image analysis, Morphology, Tissue imaging, [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34215263; info:eu-repo/grantAgreement//758457/EU/Competition for Space in Development and Diseases/CoSpaDD; info:eu-repo/grantAgreement/FP7-IDEAS-ERC - Specific programme//789573/EU/Study of the mechanical cues driving cell competition and its role in pretumoral cell expansion/MechDeath; info:eu-repo/grantAgreement/EC/FP7/337635/EU/Imaging and Regulation of the Cellular Dynamics Driving the Vertebrate Limb Formation/LIMBCELLDYNAMICS; info:eu-repo/grantAgreement//665807/EU/Institut Pasteur International Docotal Program/PASTEURDOC; info:eu-repo/grantAgreement/EC/FP7/322936/EU/Dynamics and Homeostasis of Germinal Zones in the Adult Vertebrate Brain/SYSTEMATICS; hal-03278486; https://hal.sorbonne-universite.fr/hal-03278486Test; https://hal.sorbonne-universite.fr/hal-03278486/documentTest; https://hal.sorbonne-universite.fr/hal-03278486/file/Herbert2021_Article_LocalZProjectorAndDeProjAToolb.pdfTest; PUBMED: 34215263

الإتاحة: https://doi.org/10.1186/s12915-021-01037-wTest
https://hal.sorbonne-universite.fr/hal-03278486Test
https://hal.sorbonne-universite.fr/hal-03278486/documentTest
https://hal.sorbonne-universite.fr/hal-03278486/file/Herbert2021_Article_LocalZProjectorAndDeProjAToolb.pdfTest

المؤلفون: Latorre, Ernest, Kale, Sohan, Casares, Laura, Gómez-González, Manuel, Uroz, Marina, Valon, Léo, Nair, Roshna V., Garreta, Elena, Montserrat, Nuria, del Campo, Aránzazu, Ladoux, Benoit, Arroyo, Marino, Trepat, Xavier

المصدر: Nature ; volume 592, issue 7856, page E30-E30 ; ISSN 0028-0836 1476-4687

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41586-021-03281-0Test
http://www.nature.com/articles/s41586-021-03281-0.pdfTest
http://www.nature.com/articles/s41586-021-03281-0Test

المؤلفون: Sunyer, Raimon, Conte, Vito, Escribano, Jorge, Elosegui-Artola, Alberto, Labernadie, Anna, Valon, Léo, Navajas, Daniel, García-Aznar, José Manuel, Muñoz, José J., Roca-Cusachs, Pere, Trepat, Xavier

المصدر: Science, 2016 Sep 01. 353(6304), 1157-1161.

الوصول الحر: https://www.jstor.org/stable/44710574Test

المؤلفون: Valon, Léo, Levayer, Romain

المساهمون: Département de Biologie du Développement et Cellules souches - Department of Developmental and Stem Cell Biology, Institut Pasteur Paris (IP)-Université Paris Cité (UPCité)

المصدر: ISSN: 0248-4900.

مصطلحات موضوعية: [SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30609052; hal-02644671; https://hal.science/hal-02644671Test; https://hal.science/hal-02644671/documentTest; https://hal.science/hal-02644671/fileTest/Valon%26Levayer2018-plaintext-merged.pdf; PUBMED: 30609052

الإتاحة: https://doi.org/10.1111/boc.201800075Test
https://hal.science/hal-02644671Test
https://hal.science/hal-02644671/documentTest
https://hal.science/hal-02644671/fileTest/Valon%26Levayer2018-plaintext-merged.pdf

المؤلفون: Moreno, Eduardo, Valon, Léo, Levillayer, Florence, Levayer, Romain

المساهمون: Champalimaud Centre for the Unknown Lisbon, Département de Biologie du Développement et Cellules souches - Department of Developmental and Stem Cell Biology, Institut Pasteur Paris (IP)

المصدر: ISSN: 0960-9822.

مصطلحات موضوعية: mechanotransduction, apoptosis, cell competition, EGFR, ERK, Hid, epithelium, Drosophila, [SDV.BDD]Life Sciences [q-bio]/Development Biology, [SDV.BDD.MOR]Life Sciences [q-bio]/Development Biology/Morphogenesis, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30554899; hal-02634739; https://hal.science/hal-02634739Test; https://hal.science/hal-02634739/documentTest; https://hal.science/hal-02634739/file/MainText-Figures-Methods.pdfTest; PUBMED: 30554899

الإتاحة: https://doi.org/10.1016/j.cub.2018.11.007Test
https://hal.science/hal-02634739Test
https://hal.science/hal-02634739/documentTest
https://hal.science/hal-02634739/file/MainText-Figures-Methods.pdfTest