A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia
| العنوان: | A family-based association study does not support DYX1C1 on 15q21.3 as a candidate gene in developmental dyslexia |
|---|---|
| المؤلفون: | Roberto Giorda, Nello Salandi, Alessandra Citterio, Massimo Molteni, Valentina Crespi, Silvana Beri, Cecilia Marino, Maria Luisa Lorusso, Marco Battaglia, Laura Vanzin, Maria Nobile |
| المصدر: | European Journal of Human Genetics. 13:491-499 |
| بيانات النشر: | Springer Science and Business Media LLC, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Candidate gene, Adolescent, Genotype, Nerve Tissue Proteins, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Genetic determinism, Nuclear Family, Dyslexia, DCDC2, Genetics, medicine, Humans, Genetic Predisposition to Disease, Child, Nuclear family, Genetics (clinical), Chromosomes, Human, Pair 15, Genetic heterogeneity, Nuclear Proteins, medicine.disease, Cytoskeletal Proteins, Phenotype, Female |
| الوصف: | We applied a family-based association approach to investigate the role of the DYX1C1 gene on chromosome 15q as a candidate gene for developmental dyslexia (DD) to 158 families containing at least one dyslexic child. We directly sequenced exons 2 and 10 of the DYX1C1 gene and found eight single nucleotide polymorphism (SNPs), three of which (-3G>A, 1249 G>T, 1259 C>G) were suitable for the genetic analyses. We performed single- and multimarker association analyses with DD as a categorical trait by FBAT version 1.4 and TRANSMIT version 2.5.4 programs. Our sample had a power of at least 80% to detect an association between the selected phenotypes and the informative polymorphisms at a significance level of 5%. The results of the categorical analyses did not support the involvement of the DYX1C1 gene variants in this sample of dyslexics and their relatives. Quantitative and multimarker analyses, which provide greater power to detect loci with a minor effect, consistently yielded nonsignificant results. While D1X1C1 is a good candidate gene for DD, we were unable to replicate the original findings between DYX1C1 gene and DD, perhaps due to genetic heterogeneity. |
| تدمد: | 1476-5438 1018-4813 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0dbf9bbe5887cf3789b0f18c586855Test https://doi.org/10.1038/sj.ejhg.5201356Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....9b0dbf9bbe5887cf3789b0f18c586855 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765438 10184813 |
|---|