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المساهمون: The study reported in this publication was carried out as part of a publicly funded research project within the State Assignment of the Lomonosov Moscow State University Medical Research and Educational Center., Работа выполнена в рамках государственного задания Медицинского научно-образовательного центра Московского государственного университета имени М.В. Ломоносова.

المصدر: Safety and Risk of Pharmacotherapy; Том 12, № 1 (2024); 99-116 ; Безопасность и риск фармакотерапии; Том 12, № 1 (2024); 99-116 ; 2619-1164 ; 2312-7821

مصطلحات موضوعية: местная токсичность, mesenchymal stromal cell secretome, spermatogenesis, rodents, safety, general toxicity, subchronic toxicity, local toxicity, секретóм мезенхимных стромальных клеток, сперматогенез, грызуны, безопасность, общая токсичность, субхроническая токсичность

وصف الملف: application/pdf

العلاقة: https://www.risksafety.ru/jour/article/view/364/821Test; https://www.risksafety.ru/jour/article/downloadSuppFile/364/339Test; https://www.risksafety.ru/jour/article/downloadSuppFile/364/340Test; https://www.risksafety.ru/jour/article/downloadSuppFile/364/386Test; Agarwal A, Baskaran S, Parekh N, Cho CL, Henkel R, Vij S, et al. Male infertility. Lancet. 2021;397(10271):319–33. https://doi.org/10.1016/S0140-6736Test(20)32667-2; Sagaradze G, Monakova A, Basalova N, Popov V, Balabanyan V, Efimenko A. Regenerative medicine for male infertility: a focus on stem cell niche injury models. Biomed J. 2022;45(4):607–14. https://doi.org/10.1016/j.bj.2022.01.015Test; Kharazi U, Badalzadeh R. A review on the stem cell therapy and an introduction to exosomes as a new tool in reproductive medicine. Reprod Biol. 2020;20(4):447–59. https://doi.org/10.1016/j.repbio.2020.07.002Test; Chen G, Kathrins M, Ohlander S, Niederberger C. Medical management of male infertility: now and future. Curr Opin Urol. 2023;33(1):10–5. https://doi.org/10.1097/MOU.0000000000001056Test; Ciccocioppo R, Cantore A, Chaimov D, Orlando G. Regenerative medicine: the red planet for clinicians. Intern Emerg Med. 2019;14(6):911–21. https://doi.org/10.1007/s11739-019-02126-zTest; Vieujean S, Loly JP, Boutaffala L, Meunier P, Reenaers C, Briquet A, et al. Mesenchymal stem cell injection in Crohn’s disease strictures: a phase I-II clinical study. J Crohns Colitis. 2022;16(3):506–10. https://doi.org/10.1093/ecco-jcc/jjab154Test; Chahal J, Gómez-Aristizábal A, Shestopaloff K, Bhatt S, Chaboureau A, Fazio A, et al. Bone marrow mesenchymal stromal cell treatment in patients with osteoarthritis results in overall improvement in pain and symptoms and reduces synovial inflammation. Stem Cells Transl Med. 2019;8(8):746–57. https://doi.org/10.1002/sctm.18-0183Test; Petrou P, Kassis I, Levin N, Paul F, Backner Y, Benoliel T, et al. Beneficial effects of autologous mesenchymal stem cell transplantation in active progressive multiple sclerosis. Brain. 2020;143(12):3574–88. https://doi.org/10.1093/brain/awaa333Test; Monakova A, Sagaradze G, Basalova N, Popov V, Balabanyan V, Efimenko A. Novel potency assay for MSC secretome-based treatment of idiopathic male infertility employed Leydig cells and revealed vascular endothelial growth factor as a promising potency marker. Int J Mol Sci. 2022;23(16):9414. https://doi.org/10.3390/ijms23169414Test; Sagaradze GD, Basalova NA, Efimenko AY, Tkachuk VA. Mesenchymal stromal cells as critical contributors to tissue regeneration. Front Cell Dev Biol. 2020;8:576176. https://doi.org/10.3389/fcell.2020.576176Test; Kalinina N, Kharlampieva D, Loguinova M, Butenko I, Pobeguts O, Efimenko A, et al. Characterization of secretomes provides evidence for adipose-derived mesenchymal stromal cells subtypes. Stem Cell Res Ther. 2015;6:221. https://doi.org/10.1186/s13287-015-0209-8Test; Teixeira FG, Salgado AJ. Mesenchymal stem cells secretome: current trends and future challenges. Neural Regen Res. 2020;15(1):75–7. https://doi.org/10.4103/1673-5374.264455Test; Liu J, Ding Y, Liu Z, Liang X. Senescence in mesenchymal stem cells: functional alterations, molecular mechanisms, and rejuvenation strategies. Front Cell Dev Biol. 2020;8:258. https://doi.org/10.3389/fcell.2020.00258Test; Zhuang WZ, Lin YH, Su LJ, Wu MS, Jeng HY, Chang HC, et al. Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications. J Biomed Sci. 2021;28(1):28. https://doi.org/10.1186/s12929-021-00725-7Test; Sagaradze G, Basalova N, Kirpatovsky V, Ohobotov D, Nimiritsky P, Grigorieva O, et al. A magic kick for regeneration: role of mesenchymal stromal cell secretome in spermatogonial stem cell niche recovery. Stem Cell Res Ther. 2019;10(1):342. https://doi.org/10.1186/s13287-019-1479-3Test; Sagaradze GD, Basalova NA, Kirpatovsky VI, Ohobotov DA, Grigorieva OA, Balabanyan VY, et al. Application of rat cryptorchidism model for the evaluation of mesenchymal stromal cell secretome regenerative potential. Biomed Pharmacother. 2019;109:1428–36. https://doi.org/10.1016/j.biopha.2018.10.174Test; Пошивалов ВП. Фармакоэтология. СПб: Copy-Service; 1997.; Мужикян АА, Макарова МН, Гущин ЯА. Особенности гистологической обработки органов и тканей лабораторных животных. Международный вестник ветеринарии. 2014;(2):103–9. EDN: SFLHTJ; Suckow MA, Weisbroth SH, Franklin CL, eds. The labo ratory rat. Elsevier; 2005. P. 929.; Dorato MA, Engelhardt JA. The no-observed-adverse-effect-level in drug safety evaluations: use, issues, and definition(s). Regul Toxicol Pharmacol. 2005;42(3):265–74. https://doi.org/10.1016/j.yrtph.2005.05.004Test; https://www.risksafety.ru/jour/article/view/364Test

الإتاحة: https://doi.org/10.30895/2312-7821-2023-364Test
https://doi.org/10.1016/S0140-6736Test(20)32667-2
https://doi.org/10.1016/j.bj.2022.01.015Test
https://doi.org/10.1016/j.repbio.2020.07.002Test
https://doi.org/10.1097/MOU.0000000000001056Test
https://doi.org/10.1007/s11739-019-02126-zTest
https://doi.org/10.1093/ecco-jcc/jjab154Test
https://doi.org/10.1002/sctm.18-0183Test
https://doi.org/10.1093/brain/awaa333Test
https://doi.org/10.3390/ijms23169414Test

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