Correlation of Flicker-Induced and Flow-Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers
| العنوان: | Correlation of Flicker-Induced and Flow-Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers |
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| المؤلفون: | Leopold Schmetterer, Ursula Petzl, Günther Weigert, Michael Wolzt, Gerhard Garhöfer, Berthold Pemp, Katharina Karl |
| المصدر: | Diabetes Care |
| بيانات النشر: | American Diabetes Association, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Cardiovascular and Metabolic Risk, medicine.medical_specialty, Brachial Artery, Light, Endothelium, Retinal Artery, Systole, Endocrinology, Diabetes and Metabolism, Hypercholesterolemia, Vasodilation, Flicker fusion threshold, Flicker Fusion, Reference Values, Internal medicine, medicine.artery, Internal Medicine, medicine, Humans, Brachial artery, Endothelial dysfunction, Original Research, Advanced and Specialized Nursing, business.industry, Middle Aged, medicine.disease, Retinal Vein, Arterial occlusion, Cholesterol, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Endocrinology, Blood pressure, Hypertension, cardiovascular system, Cardiology, Female, Endothelium, Vascular, business, Blood Flow Velocity |
| الوصف: | OBJECTIVE Flicker-induced vasodilatation is reduced in patients with vascular-related diseases, which has at least partially been attributed to endothelial dysfunction of retinal vessels. Currently, the standard method to assess endothelial function in vivo is flow-mediated vasodilatation (FMD). Thus, the present study was performed to investigate whether a correlation exists between flicker-induced vasodilatation and FMD in patients with known endothelial dysfunction and healthy subjects. RESEARCH DESIGN AND METHODS In the present study, 20 patients with type 1 diabetes, 40 patients with systemic hypertension (systolic blood pressure 140–159 mmHg; diastolic blood pressure 90–99 mmHg) and/or serum cholesterol levels ≥0.65 mmol/l, and 20 healthy control subjects were included. The flicker response was measured using the Dynamic Retinal Vessel Analyzer. FMD was determined using a high-resolution ultrasound system, measuring brachial artery diameter reactivity during reperfusion after arterial occlusion. RESULTS The flicker response of both retinal arteries and veins was significantly reduced in the two patients groups. Likewise, FMD was significantly reduced in patients compared with healthy control subjects. However, only a weak correlation between flicker-induced vasodilatation and FMD was observed. CONCLUSIONS The study confirms that flicker responses and FMD are reduced in the selected patient groups. Whether the weak correlation between FMD and flicker is due to the different stimulation type, the different vascular beds measured, or other mechanisms has yet to be investigated. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c06d49803a0a72cb1595f8d894b5c9bTest https://doi.org/10.2337/dc08-2130Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2c06d49803a0a72cb1595f8d894b5c9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
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